Protein Alignment Kah and ZIC1

DIOPT Version :10

• Sequence 1: NP_612040.1
• Gene: Kah / 38072
• FlyBaseID: FBgn0035144
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: NP_003403.2
• Gene: ZIC1 / 7545
• HGNCID: 12872
• Length: 447
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 80/266 - (30%)
• Similarity: 117/266 - (43%)
• Gaps: 33/266 - (12%)

  Fly    80 TSSRQSSEDHLGLQGHS------SVHHHHGEQGEILNSTSLLEDEHIC----PE--------CGK 126
            ||.|  ||.:...|.|.      ::..|||...........::.|.||    ||        |.|
Human   182 TSPR--SEHYAAPQLHGYGPMNVNMAAHHGAGAFFRYMRQPIKQELICKWIEPEQLANPKKSCNK 244

  Fly   127 KYSTSSNLARHRQTHRSIMDKKARH------CPYCEKVYVSMPAYSMHVRTH--NQGCECQF--C 181
            .:||...|..|.........:::.|      ||...|.:.:......|:|.|  .:...|.|  |
Human   245 TFSTMHELVTHVTVEHVGGPEQSNHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGC 309

  Fly   182 GKRFSRPWLLQGHIRTHTGEKPFKCGV--CEKAFADKSNLRAHIQTHSNTKPHTCARCGKAFALK 244
            ||.|:|...|:.|.|||||||||||..  |::.||:.|:.:.|:..|::.||:.|..|.|::...
Human   310 GKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHP 374

  Fly   245 SYLYKHEESSCMKNRGGVPGSGAASGNRPPSSPKRQQAEVTSGTISALAPGSPAAAVCAASDSAK 309
            |.|.||.:.....::|..|...|:||....:.|........:.|.|:|:|.| :|....|..||.
Human   375 SSLRKHMKVHESSSQGSQPSPAASSGYESSTPPTIVSPSTDNPTTSSLSPSS-SAVHHTAGHSAL 438

  Fly   310 STLANK 315
            |:..|:
Human   439 SSNFNE 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kah	NP_612040.1	C2H2 Zn finger	121..141	CDD:275368	9/31 (29%)
		zf-C2H2	176..198	CDD:395048	10/23 (43%)
		C2H2 Zn finger	178..198	CDD:275368	10/21 (48%)
		zf-H2C2_2	191..214	CDD:463886	14/24 (58%)
		zf-C2H2	204..226	CDD:395048	8/23 (35%)
		C2H2 Zn finger	206..226	CDD:275368	6/21 (29%)
		C2H2 Zn finger	234..250	CDD:275368	5/15 (33%)
ZIC1	NP_003403.2	zf_ZIC	219..264	CDD:436441	11/44 (25%)
		C2H2 Zn finger	276..296	CDD:275368	5/19 (26%)
		SFP1	<298..382	CDD:227516	35/83 (42%)
		C2H2 Zn finger	304..326	CDD:275368	10/21 (48%)
		C2H2 Zn finger	334..356	CDD:275368	6/21 (29%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..431		16/56 (29%)