Protein Alignment Kah and GLI1

DIOPT Version :10

• Sequence 1: NP_612040.1
• Gene: Kah / 38072
• FlyBaseID: FBgn0035144
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: NP_005260.1
• Gene: GLI1 / 2735
• HGNCID: 4317
• Length: 1106
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 71/268 - (26%)
• Similarity: 113/268 - (42%)
• Gaps: 38/268 - (14%)

  Fly    78 SSTSSRQSSEDHLG-LQGHSSVHHHHGEQGEILNSTSLLEDEHICPECGKKYSTSSNLARHRQTH 141
            ||.:|....:..|| |.|...:......:.|.:..|....|     .|.:::.:...|..|..:.
Human   200 SSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD-----GCSQEFDSQEQLVHHINSE 259

  Fly   142 RSIMDKKARHCPY--CEKVYVSMPAYSM---HVRTHN----QGCECQFCGKRFSRPWLLQGHIRT 197
            ....::|...|.:  |.:......|..|   |:|.|.    ..|..:.|.|.:||...|:.|:|:
Human   260 HIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRS 324

  Fly   198 HTGEKPFKC---GVCEKAFADKSNLRAH-IQTHSNTKPHTC--ARCGKAFALKSYLYKH------ 250
            ||||||:.|   | |.|||::.|:...| .:||||.||:.|  ..|.|.:...|.|.||
Human   325 HTGEKPYMCEHEG-CSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHG 388

  Fly   251 -EESSCMKNRGG--VPGSGAASGNRP----PSSPKRQQAEVT--SGTISALAPGSPAAAVCAASD 306
             :.....::||.  :|.:.:.|...|    ...|.|:::.:|  .|.:.. .|...|.:.|::..
Human   389 PDAHVTKRHRGDGPLPRAPSISTVEPKREREGGPIREESRLTVPEGAMKP-QPSPGAQSSCSSDH 452

  Fly   307 SAKSTLAN 314
            |...:.||
Human   453 SPAGSAAN 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kah	NP_612040.1	C2H2 Zn finger	121..141	CDD:275368	3/19 (16%)
		zf-C2H2	176..198	CDD:395048	8/21 (38%)
		C2H2 Zn finger	178..198	CDD:275368	7/19 (37%)
		zf-H2C2_2	191..214	CDD:463886	14/25 (56%)
		zf-C2H2	204..226	CDD:395048	8/25 (32%)
		C2H2 Zn finger	206..226	CDD:275368	8/23 (35%)
		C2H2 Zn finger	234..250	CDD:275368	5/17 (29%)
GLI1	NP_005260.1	Interaction with SUFU. /evidence=ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597	120..124
		FOXP-CC	237..>265	CDD:465036	4/32 (13%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:8378770	283..291		2/7 (29%)
		SFP1	<297..387	CDD:227516	35/90 (39%)
		C2H2 Zn finger	303..325	CDD:275368	8/21 (38%)
		C2H2 Zn finger	333..356	CDD:275368	8/23 (35%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:8378770	345..350		1/4 (25%)
		C2H2 Zn finger	364..385	CDD:275368	7/20 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..485		19/87 (22%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:8378770	375..381		2/5 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	516..580
		PHA03247	<562..1081	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..792
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	817..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..942
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1054..1087
		SNAG domain. /evidence=ECO:0000250	1..20