DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kah and Snai1

DIOPT Version :9

Sequence 1:	NP_612040.1	Gene:	Kah / 38072	FlyBaseID:	FBgn0035144	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_035557.1	Gene:	Snai1 / 20613	MGIID:	98330	Length:	264	Species:	Mus musculus

Alignment Length:	263	Identity:	96/263 - (36%)
Similarity:	127/263 - (48%)	Gaps:	60/263 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ATPIPEELYNLTQLAEVTLSVGPLVTDEVKP-----LPLYAS---------SDDDSNYYSHKVFD 57
            |.|.||.|.....|.  ||....|:..:|:|     |||..|         ||:||...|...
Mouse    43 AIPPPEVLNPAASLP--TLIWDSLLVPQVRPVAWATLPLRESPKAVELTSLSDEDSGKSSQPP-- 103

  Fly    58 RRKLRRCTISDSNSCASSSSSSTSSRQSSEDHLGLQGHSSVHHHHGEQGEILNSTSLLEDEHICP 122
                     |..:...||.||:::|...:|..:...|       .|:..:.|...|:.:|    |
Mouse   104 ---------SPPSPAPSSFSSTSASSLEAEAFIAFPG-------LGQLPKQLARLSVAKD----P 148

  Fly   123 ECGKKYSTSSNLARHRQTHRSIMDKKARHCPYCEKVYVSMPAYSMHVRTHNQGCECQFCGKRFSR 187
            :                      .:|..:|.||.|.|:|:.|..||:|:|...|.|..|||.|||
Mouse   149 Q----------------------SRKIFNCKYCNKEYLSLGALKMHIRSHTLPCVCTTCGKAFSR 191

  Fly   188 PWLLQGHIRTHTGEKPFKCGVCEKAFADKSNLRAHIQTHSNTKPHTCARCGKAFALKSYLYKHEE 252
            |||||||:|||||||||.|..|.:||||:||||||:||||:.|.:.|..|.:.|:..|.|:||:|
Mouse   192 PWLLQGHVRTHTGEKPFSCSHCNRAFADRSNLRAHLQTHSDVKRYQCQACARTFSRMSLLHKHQE 256

  Fly   253 SSC 255
            |.|
Mouse   257 SGC 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kah	NP_612040.1	zf-C2H2	119..141	CDD:278523	1/21 (5%)
		C2H2 Zn finger	121..141	CDD:275368	1/19 (5%)
		zf-C2H2	176..198	CDD:278523	16/21 (76%)
		C2H2 Zn finger	178..198	CDD:275368	15/19 (79%)
		zf-H2C2_2	191..214	CDD:290200	16/22 (73%)
		zf-C2H2	204..226	CDD:278523	14/21 (67%)
		C2H2 Zn finger	206..226	CDD:275368	13/19 (68%)
		zf-H2C2_2	218..242	CDD:290200	12/23 (52%)
		C2H2 Zn finger	234..250	CDD:275368	5/15 (33%)
Snai1	NP_035557.1	SNAG domain. /evidence=ECO:0000305	1..20
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000250\|UniProtKB:O95863	2..7
		LATS2 binding. /evidence=ECO:0000250	10..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..116		9/41 (22%)
		Destruction motif	95..100		2/4 (50%)
		Required for FBXL14-triggered degradation. /evidence=ECO:0000250	120..151		7/63 (11%)
		Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000250	151..264		63/109 (58%)
		C2H2 Zn finger	156..176	CDD:275368	10/19 (53%)
		COG5048	<177..>253	CDD:227381	46/75 (61%)
		C2H2 Zn finger	182..202	CDD:275368	15/19 (79%)
		zf-H2C2_2	195..218	CDD:290200	16/22 (73%)
		zf-C2H2	208..230	CDD:278523	14/21 (67%)
		C2H2 Zn finger	210..230	CDD:275368	13/19 (68%)
		C2H2 Zn finger	238..255	CDD:275368	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810