DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kah and ces-1

DIOPT Version :9

Sequence 1:	NP_612040.1	Gene:	Kah / 38072	FlyBaseID:	FBgn0035144	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_492338.1	Gene:	ces-1 / 185718	WormBaseID:	WBGene00000468	Length:	270	Species:	Caenorhabditis elegans

Alignment Length:	274	Identity:	105/274 - (38%)
Similarity:	151/274 - (55%)	Gaps:	57/274 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LSVGPLVTDEVKPLPLYASSDDDSNYYSHKVFDRRKLRRCTISDSNSCASSSSSSTSSRQSSEDH 89
            :|:.|.|...| ..|:..:.|..:..: |.:....::::   |.:.|.:|||||||||....:..
Worm     7 ISLTPTVAPPV-DFPIIGNCDFQAQLW-HLMSLHLQMQK---SSAASTSSSSSSSTSSENLKKSP 66

  Fly    90 LGLQGHS--SVHHHHGEQGEILNSTSL----LEDEH----------------------------- 119
            ..:|..|  |:.:       ||||..:    ||::.
Worm    67 SSVQNTSVFSIDN-------ILNSQKVPKLELENDEDVSSSPSPTCSTTGYTLDSLQNLDRRSLN 124

  Fly   120 ----------ICPECGKKYSTSSNLARHRQTHRSIMDKKARHCPYCEKVYVSMPAYSMHVRTHNQ 174
                      :|.:|||.|:|:|||:||:||||::....|:.||:|::|||||||.|||:.|||.
Worm   125 KKGPSSHNRCVCDKCGKSYATTSNLSRHKQTHRALDSPHAKQCPHCDRVYVSMPALSMHILTHNA 189

  Fly   175 GCECQFCGKRFSRPWLLQGHIRTHTGEKPFKCGVCEKAFADKSNLRAHIQTHSNTKPHTCARCGK 239
            ..||..|||||||.||||||:|:|||.:||.|..|.|:|||:||||||:.||:..|...|.:||:
Worm   190 SHECNVCGKRFSRLWLLQGHLRSHTGLRPFSCAHCGKSFADRSNLRAHMLTHTGDKRFECDKCGR 254

  Fly   240 AFALKSYLYKHEES 253
            .|||::||.:|.|:
Worm   255 RFALRAYLNRHLET 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kah	NP_612040.1	zf-C2H2	119..141	CDD:278523	12/60 (20%)
		C2H2 Zn finger	121..141	CDD:275368	12/19 (63%)
		zf-C2H2	176..198	CDD:278523	16/21 (76%)
		C2H2 Zn finger	178..198	CDD:275368	15/19 (79%)
		zf-H2C2_2	191..214	CDD:290200	13/22 (59%)
		zf-C2H2	204..226	CDD:278523	13/21 (62%)
		C2H2 Zn finger	206..226	CDD:275368	12/19 (63%)
		zf-H2C2_2	218..242	CDD:290200	11/23 (48%)
		C2H2 Zn finger	234..250	CDD:275368	8/15 (53%)
ces-1	NP_492338.1	C2H2 Zn finger	167..187	CDD:275368	13/19 (68%)
		C2H2 Zn finger	193..213	CDD:275368	15/19 (79%)
		zf-H2C2_2	206..229	CDD:290200	13/22 (59%)
		zf-C2H2	219..241	CDD:278523	13/21 (62%)
		C2H2 Zn finger	221..241	CDD:275368	12/19 (63%)
		zf-H2C2_2	233..257	CDD:290200	11/23 (48%)
		C2H2 Zn finger	249..268	CDD:275368	9/18 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159579
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D545011at33208
OrthoFinder	1	1.000	-	-		FOG0000984
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3156
SonicParanoid	1	1.000	-	-		X1445
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.780