Protein Alignment Kah and GLIS3

DIOPT Version :10

• Sequence 1: NP_612040.1
• Gene: Kah / 38072
• FlyBaseID: FBgn0035144
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: NP_001035878.1
• Gene: GLIS3 / 169792
• HGNCID: 28510
• Length: 930
• Species: Homo sapiens
• Alignment Length: 382
• Identity: 97/382 - (25%)
• Similarity: 142/382 - (37%)
• Gaps: 71/382 - (18%)

  Fly    95 HSSVHHHHGEQGEILNSTSL----LEDE---------HICP--ECGKKYSTSSNLARH-RQTHRS 143
            |:..|.||.|.|......:|    |:|:         |.|.  :|...|.....|.|| .:.|
Human   463 HAHAHLHHPELGPHAQQLALPQATLDDDGEMDGIGGKHCCRWIDCSALYDQQEELVRHIEKVH-- 525

  Fly   144 IMDKKARH-------CPYCEKVYVSMPAYSMHVRTHN----QGCECQFCGKRFSRPWLLQGHIRT 197
            |..:|...       ||...|.:.:.....:|:|.|:    ..|..:.|.|.|||...|:.|:|:
Human   526 IDQRKGEDFTCFWAGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCEKAFSRLENLKIHLRS 590

  Fly   198 HTGEKPFKC---GVCEKAFADKSNLRAHIQTHSNTKPHTC--ARCGKAFALKSYLYKH------- 250
            ||||||:.|   | |:|||::.|:...|.:||.:|||:.|  ..|.|.:...|.|.||
Human   591 HTGEKPYLCQHPG-CQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSK 654

  Fly   251 EESSCMKNRGG-------VPGSGAASGNRPPSSPKRQQAEVTSGTISALAPGSPAAAVCAASDSA 308
            |:.:..|.|..       :.........:|.:||:...||.|.|......|...:|.:.:::.|:
Human   655 EQQARKKLRSSTELHPDLLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDLYSAPIFSSNYSS 719

  Fly   309 KSTLANKLLQKEK--DRRQAAMAFQGFPAGPEVTAYSHATSAQEEYEKFKRINVIQPKVMPHRVP 371
            :|..|...:....  .........||.|..|. :.....|:.....|:|.........:.|.|||
Human   720 RSGTAAGAVPPPHPVSHPSPGHNVQGSPHNPS-SQLPPLTAVDAGAERFAPSAPSPHHISPRRVP 783

  Fly   372 ---SLYQDLLPNRHVPLALPLAMPYHFQGQATSTGQSDPTSVQEQPVDFSPKNNFTH 425
               |:.|...|            ||..|...:......|    |....|.|.....|
Human   784 APSSILQRTQP------------PYTQQPSGSHLKSYQP----ETNSSFQPNGIHVH 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kah	NP_612040.1	C2H2 Zn finger	121..141	CDD:275368	6/22 (27%)
		zf-C2H2	176..198	CDD:395048	9/21 (43%)
		C2H2 Zn finger	178..198	CDD:275368	8/19 (42%)
		zf-H2C2_2	191..214	CDD:463886	14/25 (56%)
		zf-C2H2	204..226	CDD:395048	8/24 (33%)
		C2H2 Zn finger	206..226	CDD:275368	8/22 (36%)
		C2H2 Zn finger	234..250	CDD:275368	5/17 (29%)
GLIS3	NP_001035878.1	SFP1	<558..652	CDD:227516	37/94 (39%)
		C2H2 Zn finger	569..591	CDD:275368	9/21 (43%)
		C2H2 Zn finger	599..621	CDD:275368	8/22 (36%)
		C2H2 Zn finger	629..651	CDD:275368	7/21 (33%)