DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppm1 and PPM1F

DIOPT Version :9

Sequence 1:	NP_612039.1	Gene:	Ppm1 / 38071	FlyBaseID:	FBgn0035143	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_055449.1	Gene:	PPM1F / 9647	HGNCID:	19388	Length:	454	Species:	Homo sapiens

Alignment Length:	291	Identity:	95/291 - (32%)
Similarity:	134/291 - (46%)	Gaps:	35/291 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KDTACCANASYR---VGSSCMQGWRVDMEDAH------THILSLPDDPQAAFFAVYDGHGGASVA 67
            |.....|.||.|   |....::..|..|||.|      ..:..|.|....|:|||:|||||...|
Human   142 KQVPLAARASQRQWLVSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAA 206

  Fly    68 KYAGKHLHKFITKRPEYRDNSIEVALKKAFLDFDREMLQNGSLDEQTAGCTAIVVLIRERRLYCA 132
            :||..|:|....::||...:. |.||::||...|:..|:....:...:|.|.:..||....|:.|
Human   207 RYAAVHVHTNAARQPELPTDP-EGALREAFRRTDQMFLRKAKRERLQSGTTGVCALIAGATLHVA 270

  Fly   133 NAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGGWVEFN---RVNGNLALSRALGDFIYKK 194
            ..|||:.|....|.|..|...|:|....|..||.|.||:|...   ||||.||:|||:||...|
Human   271 WLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQK- 334

  Fly   195 NLLKTPEEQIVTAYPDVEVLDITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIR----DGMEPEL 255
                    ..|:...|.....:|...:::||||||.:||:.:.||...|...:.    .|:.
Human   335 --------PYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSGLR--- 388

  Fly   256 ICEELMNSCLSPDGHTGNVGGDNMTVILVCL 286
            :.|||:.:......|      ||:||::|.|
Human   389 VAEELVAAARERGSH------DNITVMVVFL 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppm1	NP_612039.1	PP2Cc	22..286	CDD:238083	90/279 (32%)
PPM1F	NP_055449.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		PP2C	155..406	CDD:278884	85/269 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..454
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144748
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R955
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770