DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppm1 and PTC2

DIOPT Version :9

Sequence 1:	NP_612039.1	Gene:	Ppm1 / 38071	FlyBaseID:	FBgn0035143	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_011013.1	Gene:	PTC2 / 856823	SGDID:	S000000891	Length:	464	Species:	Saccharomyces cerevisiae

Alignment Length:	303	Identity:	126/303 - (41%)
Similarity:	184/303 - (60%)	Gaps:	10/303 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGQTLSEPVTTKDTACCANASYRVGSSCMQGWRVDMEDAH---THILSLPDDPQAAFFAVYDGHG 62
            |||.||.||..|::...|::....|...|||||:.|||:|   .::|:..|....||:.::||||
Yeast     1 MGQILSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHG 65

  Fly    63 GASVAKYAGKHLHKFITKRPEYRDNSIEVALKKAFLDFDREMLQNGSLDEQTAGCTAIVVLIRER 127
            ||.||:|.|..:.:.:.::..:.:.::..||...|::.|.::||:..:.|..:||||..:|:.:.
Yeast    66 GAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINTDVKLLQDPVMKEDHSGCTATSILVSKS 130

  Fly   128 R--LYCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGGWVEFNRVNGNLALSRALGDF 190
            :  |.|.||||||.:....|...|||.||||..|.|..||:|:.|:||.:|||||||||||:|||
Yeast   131 QNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDF 195

  Fly   191 IYKKNLLKTPEEQIVTAYPDV--EVLDITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGMEP 253
            .:|.|....|||||||..||:  ..||...| |||:||||||||.:::.:....||..:|:|...
Yeast   196 EFKSNPKLGPEEQIVTCVPDILEHSLDYDRD-EFVILACDGIWDCLTSQDCVDLVHLGLREGKTL 259

  Fly   254 ELICEELMNSCLSPDGHTGNVGGDNMTVILVCLLHNKSYEDLA 296
            ..|...:::.|.:|......:|.|||::::|.||  |..||:|
Yeast   260 NEISSRIIDVCCAPTTEGTGIGCDNMSIVVVALL--KEGEDVA 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppm1	NP_612039.1	PP2Cc	22..286	CDD:238083	111/270 (41%)
PTC2	NP_011013.1	PP2C	23..279	CDD:395385	106/256 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	204	1.000	Domainoid score	I537
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H122156
Inparanoid	1	1.050	233	1.000	Inparanoid score	I716
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53745
OrthoFinder	1	1.000	-	-		FOG0000692
OrthoInspector	1	1.000	-	-		mtm9234
orthoMCL	1	0.900	-	-		OOG6_100270
Panther	1	1.100	-	-	O	PTHR13832
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R955
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860