DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppm1 and PPM1D

DIOPT Version :9

Sequence 1:	NP_612039.1	Gene:	Ppm1 / 38071	FlyBaseID:	FBgn0035143	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_003611.1	Gene:	PPM1D / 8493	HGNCID:	9277	Length:	605	Species:	Homo sapiens

Alignment Length:	357	Identity:	99/357 - (27%)
Similarity:	150/357 - (42%)	Gaps:	97/357 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QTLSEPVTTKDTACCANASYRVGSSCMQGWRVDMEDAHTHILSLPD---DP----------QAAF 54
            ::||:|:..:.:.    |:...|....:|..|...:|..   .|||   .|          ..||
Human    43 RSLSQPLPPRPSP----AALPGGEVSGKGPAVAAREARD---PLPDAGASPAPSRCCRRRSSVAF 100

  Fly    55 FAVYDGHGGASVAKYAGKHLHKFITKRPEYRDN---SIEVALKKAFLDFDREMLQNGSLDE---- 112
            |||.|||||...|::|.:||..||.|:..:..:   .:..|::|.||.....|.:  .|.|
Human   101 FAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWK--KLAEWPKT 163

  Fly   113 -----QTAGCTAIVVLIRERRLYCANAGDSRAIACI-----SGMVHALSV--DHKPNDAKESKRI 165
                 .|:|.||.||:||..::|.|:.|||..:..|     ...|.|:.|  ||||...||.:||
Human   164 MTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERI 228

  Fly   166 MASGGWV----EFNRV---------NGN------------LALSRALGDF----IYKKNLLKTPE 201
            ...||.|    ..|||         ||.            ||::|||||.    .:....:.:||
Human   229 EGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPE 293

  Fly   202 EQIVTAYPD--VEVLDITEDLEFVLLACDGIWDVM---SNFEVCQFVHKRIRDGMEPELICEELM 261
                   ||  |..|| .:..::::|..||:|:::   ....:||       |..|.:.:..|..
Human   294 -------PDTSVHTLD-PQKHKYIILGSDGLWNMIPPQDAISMCQ-------DQEEKKYLMGEHG 343

  Fly   262 NSC--LSPDGHTGN-----VGGDNMTVILVCL 286
            .||  :..:...|.     :..||.:.|::|:
Human   344 QSCAKMLVNRALGRWRQRMLRADNTSAIVICI 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppm1	NP_612039.1	PP2Cc	22..286	CDD:238083	94/336 (28%)
PPM1D	NP_003611.1	Interaction with CHEK1. /evidence=ECO:0000269\|PubMed:15870257	1..101		13/64 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..90		12/53 (23%)
		PP2C	67..368	CDD:278884	91/320 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810