DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppm1 and ILKAP

DIOPT Version :9

Sequence 1:	NP_612039.1	Gene:	Ppm1 / 38071	FlyBaseID:	FBgn0035143	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_110395.1	Gene:	ILKAP / 80895	HGNCID:	15566	Length:	392	Species:	Homo sapiens

Alignment Length:	292	Identity:	95/292 - (32%)
Similarity:	141/292 - (48%)	Gaps:	47/292 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 QGWRVDMEDAHTHILSLPDD--------PQAAFFAVYDGHGGASVAKYAGKHLHK-FITKRPEYR 85
            :|.|.:|:|||..:..:.::        .:.::|||:|||||...:|:|.::||: .|.|.|:..
Human   115 KGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGD 179

  Fly    86 DNSIEVALKKAFLD----FDREMLQNGSLDEQT--AGCTAIVVLIRERRLYCANAGDSRAIAC-- 142
            ..|:|..:|:..||    .|.|.|:..|..:..  .|.||..||..:..||.||.||||||.|
Human   180 VISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRY 244

  Fly   143 -ISGMVHA---LSVDHKPNDAKESKRIMASGGWVEFNRVNGNLALSRALGDFIYKKNLLKTPEEQ 203
             .....||   ||.:|.|...:|..||..:||.|...||.|.|.:||::||..||:        .
Human   245 NEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKR--------C 301

  Fly   204 IVTAYPDVEVLDITEDLEFVLLACDGIWDVMSNFEVCQFVHK-------RIRDGMEP-----ELI 256
            .||:.||:....:|.:..|:||||||::.|.:..|...|:..       :.|:|...     |..
Human   302 GVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAA 366

  Fly   257 CEELMNSCLSPDGHTGNVGGDNMTVILVCLLH 288
            |..|.|..:.      ....||:||::|.:.|
Human   367 CNRLANKAVQ------RGSADNVTVMVVRIGH 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppm1	NP_612039.1	PP2Cc	22..286	CDD:238083	94/288 (33%)
ILKAP	NP_110395.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90
ILKAP	NP_110395.1	PP2Cc	108..390	CDD:238083	94/288 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2442
OMA	1	1.010	-	-		QHG53745
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770