DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppm1 and Ppm1d

DIOPT Version :9

Sequence 1:	NP_612039.1	Gene:	Ppm1 / 38071	FlyBaseID:	FBgn0035143	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_058606.3	Gene:	Ppm1d / 53892	MGIID:	1858214	Length:	598	Species:	Mus musculus

Alignment Length:	346	Identity:	94/346 - (27%)
Similarity:	142/346 - (41%)	Gaps:	95/346 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGQTLSEPVTTKDTACCANASYRVGSSCMQGWRVDMEDAHTHILSLPDDPQAAFFAVYDGHGGAS 65
            :|.:...|...:|.|..|.||...|..|.:...|                  |||||.|||||..
Mouse    58 VGPSEKGPAAARDPAPDAAASLPAGRCCRRRSSV------------------AFFAVCDGHGGRE 104

  Fly    66 VAKYAGKHLHKFITKRPEYRDN---SIEVALKKAFLDFDREMLQNGSLDE---------QTAGCT 118
            .|::|.:||..||.|:..:..:   .:..|::|.||.....|.:  .|.|         .|:|.|
Mouse   105 AAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWK--KLAEWPKTMTGLPSTSGTT 167

  Fly   119 AIVVLIRERRLYCANAGDSRAIACI-----SGMVHALSV--DHKPNDAKESKRIMASGGWVEFNR 176
            |.||:||..::|.|:.|||..:..|     ...|.|:.|  ||||...||.:||...||.| .|:
Mouse   168 ASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSV-MNK 231

  Fly   177 VNGN--------------------------LALSRALGDF----IYKKNLLKTPEEQIVTAYPD- 210
            ...|                          ||::|||||.    .:....:.:||       ||
Mouse   232 SGVNRVVWKRPRLTHSGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGKFVVSPE-------PDT 289

  Fly   211 -VEVLDITEDLEFVLLACDGIWDVM---SNFEVCQ-FVHKRIRDGMEPELICEELMNSCLSPDGH 270
             |..||..:. ::::|..||:|:::   ....:|| ...|:...|.:.:...:.|:|..|
Mouse   290 SVHTLDPRKH-KYIILGSDGLWNMVPPQDAISMCQDQEEKKYLMGEQGQSCAKMLVNRAL----- 348

  Fly   271 TGN-----VGGDNMTVILVCL 286
             |.     :..||.:.|::|:
Mouse   349 -GRWRQRMLRADNTSAIVICI 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppm1	NP_612039.1	PP2Cc	22..286	CDD:238083	86/323 (27%)
Ppm1d	NP_058606.3	Interaction with CHEK1. /evidence=ECO:0000250	1..94		11/53 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..74		4/15 (27%)
		PP2C	84..361	CDD:278884	83/311 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..419
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..584
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810