DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppm1 and PPM1E

DIOPT Version :9

Sequence 1:	NP_612039.1	Gene:	Ppm1 / 38071	FlyBaseID:	FBgn0035143	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_055721.3	Gene:	PPM1E / 22843	HGNCID:	19322	Length:	755	Species:	Homo sapiens

Alignment Length:	292	Identity:	89/292 - (30%)
Similarity:	135/292 - (46%)	Gaps:	37/292 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 CCA-----------NASYRVGSSCMQGWRVDMEDAHTHI------LSLPDDPQAAFFAVYDGHGG 63
            ||:           ...|......::..|..|||.|..|      .:|.|..:.|:|||:|||||
Human   213 CCSWVKDFPLRRRPQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGG 277

  Fly    64 ASVAKYAGKHLHKFITKRPEYRDNSIEVALKKAFLDFDREMLQNGSLDEQTAGCTAIVVLIRERR 128
            ...|.||..|||..:.::..:..:..| ||.:||...|...:|..:.:....|.|.:|..||...
Human   278 VDAAIYASIHLHVNLVRQEMFPHDPAE-ALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNM 341

  Fly   129 LYCANAGDSRAIACISGMVHALSVDHKPNDAKESKRIMASGG---WVEFNRVNGNLALSRALGDF 190
            |:.|..|||:.:....|....|...|||:...|.:||.|.||   |....||||:|::|||:||.
Human   342 LHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDA 406

  Fly   191 IYKKNLLKTPEEQIVTAYPDVEVLDITEDLEFVLLACDGIWDVMSNFEVCQFVHKRIRDGM-EPE 254
            .:|..:....:....       |||.|||  :::|||||.:|.::..|..:.|...:::.. :..
Human   407 EHKPYICGDADSAST-------VLDGTED--YLILACDGFYDTVNPDEAVKVVSDHLKENNGDSS 462

  Fly   255 LICEELMNSCLSPDGHTGNVGGDNMTVILVCL 286
            ::..:|:.|.....      ..||:|||:|.|
Human   463 MVAHKLVASARDAG------SSDNITVIVVFL 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppm1	NP_612039.1	PP2Cc	22..286	CDD:238083	86/273 (32%)
PPM1E	NP_055721.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..131
		11 X 2 AA tandem repeats of P-E	31..52
		PP2Cc	230..488	CDD:238083	86/273 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R955
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840