Protein Alignment Hipk and DYRK4

DIOPT Version :9

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_001358230.1
• Gene: DYRK4 / 8798
• HGNCID: 3095
• Length: 635
• Species: Homo sapiens
• Alignment Length: 648
• Identity: 179/648 - (27%)
• Similarity: 270/648 - (41%)
• Gaps: 154/648 - (23%)

  Fly    63 LQQQQQQHILRQPATSASTSSV------------AAAATSKRKRQTDCDCGCVDSYNSSHGPPVQ 115
            |.|:.|.| .:.||:....|.:            |...:.|:::.|......:..:.:...|..|
Human   106 LYQENQAH-NQMPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQ 169

  Fly   116 QDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQLV 180
            .:....|....:|.:|            ..|.||..|.            ||.|.....|.|..|
Human   170 SEILGYAELWFLGLEA------------KKLDTAPEKF------------SKTSFDDEHGFYLKV 210

  Fly   181 QHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQ 245
            .|:   .::..|||||.:|:|:||||.||.....:|:||:||::|...:.:|..:|:.||..|.:
Human   211 LHD---HIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRK 272

  Fly   246 ENADE-FNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLK 309
            ::.|. :|.|...:.|..:||.|:.||:|..|||:.:|.|.|....|..:|.....||..|..|.
Human   273 KDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLS 337

  Fly   310 QLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEA 374
            ...:||.|||||||:|..  :....||||||||:.:..:.| .||:|||:||:||:|||.|:..|
Human   338 VEKIIHCDLKPENIVLYQ--KGQASVKVIDFGSSCYEHQKV-YTYIQSRFYRSPEVILGHPYDVA 399

  Fly   375 IDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFW 439
            ||||||||:.|||:.|:||:||.:|.:|:..|.:..|||....:.:||:...||
Human   400 IDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFF----------- 453

  Fly   440 RLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTID 504
                             :::.:..|..::.|:...|...:...:|  ||....|:|.|:|.|..:
Human   454 -----------------DSKGFPKNITNNRGKKRYPDSKDLTMVL--KTYDTSFLDFLRRCLVWE 499

  Fly   505 QERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGDFHTVQPASTLV---TNFVPSS 566
            ...|:||.:||.|::...:        .|:|.                ||....:   .:|.||.
Human   500 PSLRMTPDQALKHAWIHQS--------RNLKP----------------QPRPQTLRKSNSFFPSE 540

  Fly   567 TENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPS 631
            |..          .:||......|                       :.|....:...
Human   541 TRK----------DKVQGCHHSSR-----------------------KADEITKETTE------- 565

  Fly   632 YQTMPSPTKHV----------VVGSATMQPP--LQVPPQQYVNVPVPVSMVEPTSGQRMLLTN 682
             :|..||||||          ..|:.|:|.|  :..|.:....|...|||..|...:...|.|
Human   566 -KTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKN 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	122/328 (37%)
		PHA03378	<1080..1327	CDD:223065
DYRK4	NP_001358230.1	PKc_DYRK4	175..515	CDD:271127	136/399 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840