DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and YAK1

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_012394.1	Gene:	YAK1 / 853300	SGDID:	S000003677	Length:	807	Species:	Saccharomyces cerevisiae

Alignment Length:	597	Identity:	193/597 - (32%)
Similarity:	286/597 - (47%)	Gaps:	120/597 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SYPPKASDFVDYAVAGGGGSGFCSGLGAGLSVRATSFYGDQTVTATTDGTRHQEQQQQQLQQ--- 65
            |||...|.  :.::||.....:.||                          :|:||||..||
Yeast   146 SYPAYTSS--NTSLAGNSSGQYPSG--------------------------YQQQQQQVYQQGAI 182

  Fly    66 --------------QQQQHILRQPATSASTSSVAAAATSKRKRQTD-----CDCGCVDSYNSSHG 111
                          .:|....||...:.:.||..::..|...:.|:     .....:.:|..|..
Yeast   183 HPSQFGSRFVPSLYDRQDFQRRQSLAATNYSSNFSSLNSNTNQGTNSIPVMSPYRRLSAYPPSTS 247

  Fly   112 PPVQ---------------------------QDSSAAAGA------GSVGSKAGSGPGPDGIGPI 143
            ||:|                           .|......|      .|:.||.        |.|:
Yeast   248 PPLQPPFKQLRRDEVQGQKLSIPQMQLCNSKNDLQPVLNATPKFRRASLNSKT--------ISPL 304

  Fly   144 ----SSLKTAHT--------KVATSGGHANTQPPSKRSSSGAD---GDYQLVQHEVL-YSLSAEY 192
                .||.|.::        :.:.:.....|:|...:.::|.|   .||.|..::|| ...:.:|
Yeast   305 VSVTKSLITTYSLCSPEFTYQTSKNPKRVLTKPSEGKCNNGFDNINSDYILYVNDVLGVEQNRKY 369

  Fly   193 EVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQ--ENADEFNFVR 255
            .||:.||:|||||||||....|.||:|:|::|:...|..|...|..||..|:|  :..::.:|:|
Yeast   370 LVLDILGQGTFGQVVKCQNLLTKEILAVKVVKSRTEYLTQSITEAKILELLNQKIDPTNKHHFLR 434

  Fly   256 AFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKP 320
            .::.|.||||.|||||:|..|||:.||||||..|.::.||....|:|.:|..||:..|||.||||
Yeast   435 MYDSFVHKNHLCLVFELLSNNLYELLKQNKFHGLSIQLIRTFTTQILDSLCVLKESKLIHCDLKP 499

  Fly   321 ENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVA 385
            |||:|..|.:.  .:|:|||||:...::|| .||:|||:|||||||||:|:..:||||||||:||
Yeast   500 ENILLCAPDKP--ELKIIDFGSSCEEARTV-YTYIQSRFYRAPEIILGIPYSTSIDMWSLGCIVA 561

  Fly   386 ELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYR----DVDSTYPFWRLKTTEE 446
            |||||.|::||:||::|:..|..|.|.|...|::....:.||..:    :..|:....|:||.||
Yeast   562 ELFLGIPIFPGASEYNQLTRIIDTLGYPPSWMIDMGKNSGKFMKKLAPEESSSSTQKHRMKTIEE 626

  Fly   447 HEAETNTKSKEARKYI-FNCLDD-IGQVNVPTDLEGGQ-LLAEKTDRRE-FIDLLKRMLTIDQER 507
            ...|.|...|.:::|. :..|.| |.....|..::..| |:.::...|| .|..|..:|.::...
Yeast   627 FCREYNIVEKPSKQYFKWRKLPDIIRNYRYPKSIQNSQELIDQEMQNRECLIHFLGGVLNLNPLE 691

  Fly   508 RLTPAEALNHSF 519
            |.||.:|:.|.|
Yeast   692 RWTPQQAMLHPF 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	147/338 (43%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
YAK1	NP_012394.1	PKc_YAK1	369..704	CDD:271114	147/338 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	254	1.000	Domainoid score	I328
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto99123
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X805
TreeFam	0	0.000	Not matched by this tool.
	7	6.940