Protein Alignment Hipk and DYRK3

DIOPT Version :9

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_003573.2
• Gene: DYRK3 / 8444
• HGNCID: 3094
• Length: 588
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 155/527 - (29%)
• Similarity: 228/527 - (43%)
• Gaps: 111/527 - (21%)

  Fly    33 LSVRATSFYGDQTVTATTDGTRHQEQQQQQLQQQQQQHILRQPATSASTSSVAAAATSKRKRQTD 97
            |::....|.||.|......|....||..|:...::...|    .:...:.|...:.|..:.:.:|
Human    62 LNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTI----QSDGISDSEKCSPTVSQGKSSD 122

  Fly    98 CDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLK------TAHTKVA-- 154
            | ...|.|.:||..|.|..                       :.|..:||      ||:.|:.
Human   123 C-LNTVKSNSSSKAPKVVP-----------------------LTPEQALKQYKHHLTAYEKLEII 163

  Fly   155 -----------TSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVK 208
                       ....|.....|:......|||.|..|..:   .|:..||||:.:|:|:||||.:
Human   164 NYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRD---HLAYRYEVLKIIGKGSFGQVAR 225

  Fly   209 CWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRL-SQENADEFNFVRAFECFQHKNHTCLVFEM 272
            .:.....:.||:|:::|...:.||...|:.||..| .|:.....|.:...|.|..:||.|:.||:
Human   226 VYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFEL 290

  Fly   273 LEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKV 337
            |..:||:.:|:|||....::.:|...:.:|.:|..|.:..:||.|||||||:|....|.  ..||
Human   291 LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRS--STKV 353

  Fly   338 IDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQ 402
            |||||:....:.: .||:|||:|||||||||..:...||:||.||::|||..|.||:||..|.||
Human   354 IDFGSSCFEYQKL-YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ 417

  Fly   403 IRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLD 467
            :..:.:..|:|...:|.. ||.:|:|                        ..||...:|   |
Human   418 LACMMELLGMPPPKLLEQ-SKRAKYF------------------------INSKGIPRY---C-- 452

  Fly   468 DIGQVNVPTDLEGGQLLAEKTDRRE----------------------FIDLLKRMLTIDQERRLT 510
                 :|.|..:|..:|.....||.                      ||:.|||.|..|...|||
Human   453 -----SVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLT 512

  Fly   511 PAEALNH 517
            ||:||.|
Human   513 PAQALRH 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	121/349 (35%)
		PHA03378	<1080..1327	CDD:223065
DYRK3	NP_003573.2	Disordered. /evidence=ECO:0000305|PubMed:23415227	1..188		28/153 (18%)
		PKc_DYRK2_3	143..522	CDD:271126	135/418 (32%)
		S_TKc	209..522	CDD:214567	121/349 (35%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:29973724	468..481		2/12 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840