DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and AT1G73460

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001319375.1	Gene:	AT1G73460 / 843681	AraportID:	AT1G73460	Length:	1169	Species:	Arabidopsis thaliana

Alignment Length:	579	Identity:	147/579 - (25%)
Similarity:	240/579 - (41%)	Gaps:	120/579 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KTSYPPKASDFVDYAVAGGGGSGFCSGLGAGLSVRATSFYGDQTVTATTDGTRHQEQQQQQLQQQ 66
            |.......:|..|| :|....||       ...|:..:..|....::..||.....:..:.|...
plant   656 KNKQQASKNDGPDY-IADNDSSG-------SFHVKIQTDGGFSFGSSQKDGQSMHAESSKSLWSG 712

  Fly    67 QQQHILRQPAT---SASTSSVAAAATSKRKRQ---------TDCDCGCVDSYNSS---------- 109
            ..:.:.|...|   ||||:.....||.:||..         .|.:...:.|.|||
plant   713 NHETVTRDRNTERLSASTAMDDMVATWRRKSSDSSSSHSSVKDNNATSIKSLNSSPSSLSNYACE 777

  Fly   110 ------------HGPPVQQDSSAAAG---AGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGH 159
                        ....::.|::.|..   |.:|..:.......:.......||..|.|
plant   778 ERKHADKEDDRNDSSEIEDDNATALDDEEAVAVQEQVRQIKAQEEEFETFDLKIVHRK------- 835

  Fly   160 ANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILK 224
                   .|:....:.::.:|.:.|   ::..|.|.|:||...|.:.::.....|...|.|||:|
plant   836 -------NRTGFEEEKNFNVVLNSV---IAGRYHVTEYLGSAAFSKAIQAHDLQTGMDVCIKIIK 890

  Fly   225 NHPSYARQGQIEVSILSRLSQEN-ADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSP 288
            |:..:..|...|:.:|..:::.: ||:::.:|.::.|.::.|..:|.|:|:.|||:|.|.|:.|.
plant   891 NNKDFFDQSLDEIKLLKYVNKHDPADKYHLLRLYDYFYYREHLLIVCELLKANLYEFHKFNRESG 955

  Fly   289 LPLKYIRPILE----QVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKT 349
            ..:.:..|.|:    |.|.:|..|..|||||.|||||||::....|  ..:||||.||:...:..
plant   956 GEVYFTMPRLQSITIQCLESLQFLHGLGLIHCDLKPENILVKSYSR--CEIKVIDLGSSCFETDH 1018

  Fly   350 VCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPT 414
            :| :|:|||.|||||:|||||:.:.||:|||||::|||..|..|:...|....:..:....|...
plant  1019 LC-SYVQSRSYRAPEVILGLPYDKKIDVWSLGCILAELCTGNVLFQNDSPASLLARVMGIVGSFD 1082

  Fly   415 EHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLE 479
            ..||.....:.|:|.::          :...|...|:|.                        ||
plant  1083 NEMLTKGRDSHKYFTKN----------RMLYERNQESNR------------------------LE 1113

  Fly   480 GGQLLAEKTDRRE--------FIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVY 530
              .|:.::|..|.        |.|.:..:|.|:.::|.:.||||.|.:      :.|.|
plant  1114 --YLIPKRTSLRHRLPMGDQGFTDFVAHLLEINPKKRPSAAEALKHPW------LSYPY 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	107/340 (31%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
AT1G73460	NP_001319375.1	PKc_DYRK_like	858..1160	CDD:271035	107/346 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24058
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910