Protein Alignment Hipk and Hipk3

DIOPT Version :9

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: XP_038961862.1
• Gene: Hipk3 / 83617
• RGDID: 619884
• Length: 1213
• Species: Rattus norvegicus
• Alignment Length: 1252
• Identity: 480/1252 - (38%)
• Similarity: 624/1252 - (49%)
• Gaps: 293/1252 - (23%)

  Fly   154 ATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIV 218
            ||:|        ||::.:..:|||||||||||.|:...||||:||||||||||||||||||:|||
  Rat   167 ATTG--------SKQNCTSGEGDYQLVQHEVLCSVKNTYEVLDFLGRGTFGQVVKCWKRGTNEIV 223

  Fly   219 AIKILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQ 283
            ||||||||||||||||||||||:|||.|||||:|||||:|||||:||||||||||||||||||||
  Rat   224 AIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ 288

  Fly   284 NKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK 348
            |||||||||.|||:|:||.|||.|||.||||||||||||||||||||||||||||||||||||||
  Rat   289 NKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK 353

  Fly   349 TVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLP 413
            |||:|||||||||||||||||||||||||||||||:||||||||||||:.|:|||||||||||||
  Rat   354 TVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLP 418

  Fly   414 TEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDL 478
            .|.:||..:|:::||.|:.|.::..|||||.|||||||..|||||||||||.||||..||...||
  Rat   419 GEQLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNTVMDL 483

  Fly   479 EGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEV 543
            ||..|||||.|||||:.|||:||.||.:.|:||.|.|||.|..:.||:|:.:.::||:...:|::
  Rat   484 EGSDLLAEKADRREFVSLLKKMLLIDADLRITPIETLNHPFVSMKHLLDFPHSSHVKSCFHIMDI 548

  Fly   544 CR---------RGDFHTVQPAST-----LVTNFVPSSTENMTFTINNQ-LTSQVQRLVRDGRPLA 593
            |:         ......::|.::     |..||....      |:.:| ||:....:|..|.||
  Rat   549 CKSPSSCETNNHSKMSLLRPVASNGTAALAANFTKVG------TLRSQALTTSAHSVVHHGIPL- 606

  Fly   594 YEGLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMPS----PTKHVV-----VGSATM 649
            ..|..|...|            |:| ||.:  |:|||:.|.:|:    ||.:.:     |...|.
  Rat   607 QAGTAQFGCG------------DAF-HQTL--IICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQ 656

  Fly   650 QP---PLQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQT--GR-QMALVPSWPQ-- 706
            .|   |||:.|                              ||...||  || |..|:|:|.|
  Rat   657 APAVQPLQIRP------------------------------GVLSQQTWSGRTQQMLIPAWQQVT 691

  Fly   707 -QAPAHSLIVD-----STPLFNVEEIYP-KHHLN------LPRNDLKKESPAHHIAKGNSYRV-- 756
             .|||.:.:..     |..|.:..::.| .:|.|      |..|.:...:| ..|:.|.::.|
  Rat   692 PMAPAAATLTSEGMAGSQRLGDWGKMIPHSNHYNSVMPPPLLTNQITLSAP-QPISVGIAHVVWP 755

  Fly   757 -PRHEKKEHQ-QLSPVKKRVKESSPPHQQ----RYQRAAHVSPQYHAHHNCNYGNGSGYSASAGS 815
             |...||... |...:..::.|..|..::    |:..:.         .|.|
  Rat   756 QPATTKKNKLCQNRGILVKLMEWEPGREEINAFRWSNSL---------QNTN------------- 798

  Fly   816 VVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAH 880
             |..||..|..|::|...    ..|.....|...:|.|.  ...|                   |
  Rat   799 -VPHSAFISPKIISGKEV----EEVSCVETQDNHTSEGE--ARTC-------------------H 837

  Fly   881 QQHGQQPHPQSSQHPQHVKQPTITIHDTPSP-TAVITI-SDSEDEGGEAGGAQVPVLKQ-RAHAQ 942
            :...:|....|.:..|     ||.|.|:||| .:|||| ||::||    ..:..|.|:: :....
  Rat   838 EASVRQDSSVSDKQRQ-----TIIIADSPSPAVSVITISSDTDDE----ETSPRPSLRECKGSLD 893

  Fly   943 SQTSGSLLQ-------HAPSSSCSRSSAHQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAA 1000
            .:...|.|.       .:|.|:.|.||:.|. .|.|.::..   :..|.:.|       :.....
  Rat   894 CEACQSTLNIDRMCSLSSPDSTLSTSSSGQS-SPSPCKRPN---SMSDDEQE-------SGCETV 947

  Fly  1001 VGSPKHHHHQQQQQPAPPPQQQQQQYQPQPPPQQVL----PQPQPSIKYEP--GQSQKKRILA-M 1058
            .|||.   .......:|..:....:..||.|.....    .:|..|...||  |..:...:.| |
  Rat   948 DGSPT---SDSSGHDSPFAESSFVEDTPQNPELGTCAGTEAKPALSTAVEPPVGTERGLNVDAHM 1009

  Fly  1059 AQSECGYQPQVP--------SQPSSSASLPHIPTKQEPAEFYPEYA-AAPPQQLDTKRSSWAPTS 1114
            |.::...||...        :|||:||:....||    :.|..::. .:..|...|....|
  Rat  1010 ANTDSTCQPLTKGQPAPGKLNQPSASAARQQKPT----SAFQQQHLNLSQVQHFGTGHQEW---- 1066

  Fly  1115 SGSGVSALPLAHPKREAPSVAPISYVAPSVAPPLAHSKSSSASSSSSISAATAAAAAAAAAAAAS 1179
            :|:      |.|.:::|       |:..||         :|...:.|..:....|..|..|.:|.
  Rat  1067 NGN------LGHRRQQA-------YIPTSV---------TSNPFTLSHGSPNHTAVHAHLAGSAH 1109

  Fly  1180 VGPPSWGPPQVYRQPSQPPPGSVGLPGSTQPPPSSVAPHPHHHSHGHHHHQAGTPLGGSPSSTAA 1244
            :|    |.|.:.     |.|.|..|        ||.||..|              |..||.:  :
  Rat  1110 LG----GQPTLL-----PYPPSTAL--------SSAAPVAH--------------LLASPCT--S 1141

  Fly  1245 AALLQPDIY----AQGDIYRRPTVFVSQAAPSYAYANRAVVAPPPAHNSSSRQVIPSHPLPAHIQ 1305
            ..:||...|    ..|.:::.|.....:..||           |..|.:..:.:.|.|   ::|.
  Rat  1142 RPMLQHPTYNISHPSGIVHQVPVGINPRLLPS-----------PTIHQTQYKPIFPPH---SYIA 1192

  Fly  1306 IPTQYSQFGPLSPAQVA 1322
            ....|:.| ||||.:::
  Rat  1193 ASPAYTGF-PLSPTKLS 1208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	269/327 (82%)
		PHA03378	<1080..1327	CDD:223065	52/248 (21%)
Hipk3	XP_038961862.1	STKc_HIPK3	196..525	CDD:271131	269/328 (82%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353902
Domainoid	1	1.000	582	1.000	Domainoid score	I200
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	700	1.000	Inparanoid score	I640
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38932at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44678
orthoMCL	1	0.900	-	-		OOG6_103159
Panther	1	1.100	-	-	O	PTHR24058
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X805
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.800