DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and YAK1

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_198447.2	Gene:	YAK1 / 833590	AraportID:	AT5G35980	Length:	956	Species:	Arabidopsis thaliana

Alignment Length:	1147	Identity:	279/1147 - (24%)
Similarity:	423/1147 - (36%)	Gaps:	368/1147 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 VDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPI-----------SSLKTAHTKVATS 156
            :|..:||       |.:|||.||.:||...|.|..    ||           .|....|..|...
plant     1 MDDIDSS-------DGAAAARAGEIGSIGVSTPWK----PIQLVFKRYLPQNGSASKVHVAVKKP 54

  Fly   157 ----------------------GGHANTQPPSKRSSSGADGD-YQLVQHEVLYSLSAE------- 191
                                  .|..|.:......|.|.:.| :..|.::::.:::.:
plant    55 VVVRLTRDLVETYKICDPQFKYRGELNPKRYLTTPSVGVNNDGFDNVNYDLILAVNDDFCSSDSR 119

  Fly   192 --YEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQ--ENADEFN 252
              |.|.:.||.||||||.|||...|:..||:|::||..:|.:|..:|||||:.|::  :..|:.:
plant   120 QRYIVKDLLGHGTFGQVAKCWVPETNSFVAVKVIKNQLAYYQQALVEVSILTTLNKKYDPEDKNH 184

  Fly   253 FVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHAD 317
            .||.::.|.|::|.|:.||:|:.|||:.:|.|:|..|.|..::...:|:|..|..||..|:||.|
plant   185 IVRIYDYFLHQSHLCICFELLDMNLYELIKINQFRGLSLSIVKLFSKQILLGLALLKDAGIIHCD 249

  Fly   318 LKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGC 382
            ||||||:|...|: |..:|:||||||....||| .:|:||||||:||::||..:..||||||.||
plant   250 LKPENILLCASVK-PTEIKIIDFGSACMEDKTV-YSYIQSRYYRSPEVLLGYQYTTAIDMWSFGC 312

  Fly   383 VVAELFLGWPLYPGSSEFDQIRYISQTQG-LPTEHMLNSASKTSKFF--------------YRDV 432
            :|||||||.||:||.||||.:|.:.:..| .|.:::|..|..|:|||              |..:
plant   313 IVAELFLGLPLFPGGSEFDILRRMIEILGKQPPDYVLKEAKNTNKFFKCVGSVHNLGNGGTYGGL 377

  Fly   433 DSTYPFWRLKTTEEHEAETNTKSKEARKYIFN--CLDDI-----GQVNVPTDLEGGQLLAEKTDR 490
            .|.|   ...|.||.||....|.:..::| ||  .|::|     .::|:|.|    .::.|...|
plant   378 KSAY---MALTGEEFEAREKKKPEIGKEY-FNHKNLEEIVKSYPYKINLPED----DVVKETQIR 434

  Fly   491 REFIDLLKRMLTIDQERRLTPAEALNHSF---------------TRLTHLVDYVYCNNVKAS--- 537
            ...||.||.::..|..:|.:|.:|..|.|               |...|:.     .|:|..
plant   435 LALIDFLKGLMEFDPAKRWSPFQAAKHPFITGEPFTCPYNPPPETPRVHVT-----QNIKVDHHP 494

  Fly   538 ---------------------------VQMMEVCRRGDFHTV-----QPASTLVTNFVPS--STE 568
                                       .|||.......:.::     ....|:..|...|  .|.
plant   495 GEGHWFAAGLSPHVSGRTRIPMHNSPHFQMMPYSHANSYGSIGSYGSYNDGTIQDNSYGSYGGTG 559

  Fly   569 NMTFTINNQLTSQVQRLVRDGRPLAYEGLY-QIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSY 632
            || |...:              |:.:.||| |...|.|:....|..|....|:...:.   |...
plant   560 NM-FAYYS--------------PVNHPGLYMQNQGGVSMLGTSPDARRRVMQYPHGNG---PNGL 606

  Fly   633 QTMPSPTKHVVVGSATMQP-PLQVPPQQYVNVPVPVSMVEPTSGQRMLL--------TNRVQAS- 687
            .|.||        :....| ||...|.|:.          |.:..:.|.        |:.|:.|
plant   607 GTSPS--------AGNFAPLPLGTSPSQFT----------PNTNNQFLAGSPGHHGPTSPVRNSC 653

  Fly   688 -------GVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIYPKHHLNLPRNDLKKESPA 745
                   ..|:.|..|:|:...|...|:...||                             |.|
plant   654 HGSPLGKMAAFSQINRRMSAGYSGGSQSQDSSL-----------------------------SQA 689

  Fly   746 HHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPPHQQRYQRAAHVSPQYHAHHNCNYGNGSGYS 810
            ......|.|   ::|....|......:|..:|...::::.|....:|..|..|:|.|
plant   690 QGHGMDNFY---QNEGYSGQFSGSPSRRQLDSGVKNRKQTQGGTTLSTGYSTHNNAN-------- 743

  Fly   811 ASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQP 875
                      ::..||:.|                   .||:.||:
plant   744 ----------SSLRSNMYN-------------------PSSTAHHL------------------- 760

  Fly   876 PAHAHQQHGQQPHPQSSQHPQHVKQPTITIHDTPSP--------TAVITISDSEDE--------- 923
                             ::|.       |....|.|        ..::...||.||
plant   761 -----------------ENPD-------TALSVPDPGDWDPNYSDDLLLEEDSADESSLANAFSR 801

  Fly   924 GGEAGGAQVPVLKQRAHAQSQTSGS----LLQHAPSSSCSRSSAHQQPHPHPQQQQQQQINYGDH 984
            |.:.|........:|.::.:.||.|    ..::||:.:.|:......|...|..:      :|.|
plant   802 GMQLGSTDASSYSRRFNSNASTSSSNPTTQRRYAPNQAFSQVETGSPPSNDPHAR------FGQH 860

  Fly   985 DPEDARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQQQQQQYQPQPP-------PQQVLPQPQPS 1042
            .|               || ::..|..|..|:...||..|:|....|       ...:..|..||
plant   861 IP---------------GS-QYIPHVSQNSPSRLGQQPPQRYNHGRPNAGRTMDRNHMNAQLPPS 909

  Fly  1043 IKYEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASLPHIPT 1084
            .....||.:..|       ...|...||....::..:|::|:
plant   910 NTNSGGQQRSPR-------SSSYTNGVPWGRRTNNHVPNVPS 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	145/366 (40%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065	2/5 (40%)
YAK1	NP_198447.2	PKc_YAK1	122..464	CDD:271114	144/351 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	245	1.000	Domainoid score	I555
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24058
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910