DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and FC2

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_194205.1	Gene:	FC2 / 828576	AraportID:	AT4G24740	Length:	427	Species:	Arabidopsis thaliana

Alignment Length:	486	Identity:	136/486 - (27%)
Similarity:	219/486 - (45%)	Gaps:	90/486 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 QQQQLQQQQQQHILRQPATSASTS-SVAAAATSKRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAA 122
            :.:::.:....|:.|:|...|... .|...||   |.|....||              |:
plant     2 EMERVHEFPHTHMDRRPRKRARLGWDVLPQAT---KAQVGMFCG--------------QE----- 44

  Fly   123 GAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYS 187
             .|::.|.|.||...|.          .:.:...|...|..||.:....  ||.|..   |:...
plant    45 -IGNISSFASSGAPSDN----------SSSLCVKGVARNGSPPWREDDK--DGHYIF---ELGDD 93

  Fly   188 LSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADEFN 252
            |:..|::...:|.||||||::||.|...|:||:||::....|.....||:.:|.:|.:.:.....
plant    94 LTPRYKIYSKMGEGTFGQVLECWDRERKEMVAVKIVRGVKKYREAAMIEIEMLQQLGKHDKGGNR 158

  Fly   253 FVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHAD 317
            .|:....|.::||.|:|||.|..:|||||::|.:...|:..:|.|..|:|..:..:..|.:||.|
plant   159 CVQIRNWFDYRNHICIVFEKLGSSLYDFLRKNNYRSFPIDLVREIGWQLLECVAFMHDLRMIHTD 223

  Fly   318 LKPENIMLV--DPVRQP------------YR-------VKVIDFGSASHVSKTVCNTYLQS-RYY 360
            ||||||:||  |.|:.|            |:       :|||||||.::..:.  .||:.| |:|
plant   224 LKPENILLVSSDYVKIPEYKGSRLQRDVCYKRVPKSSAIKVIDFGSTTYERQD--QTYIVSTRHY 286

  Fly   361 RAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTS 425
            ||||:||||.:....|:||:||::.||..|..|:......:.:..:.:..|...:.||....:.|
plant   287 RAPEVILGLGWSYPCDVWSVGCIIVELCTGEALFQTHENLEHLAMMERVLGPFPQQMLKKVDRHS 351

  Fly   426 KFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDR 490
            :.:.|.....:|             ....|:::.|.:         :.:|. |:  .|:.:..|.
plant   352 EKYVRRGRLDWP-------------DGATSRDSLKAV---------LKLPR-LQ--NLIMQHVDH 391

  Fly   491 R--EFIDLLKRMLTIDQERRLTPAEALNHSF 519
            .  |.|::::.:|..|...|:|..|||.|.|
plant   392 SAGELINMVQGLLRFDPSERITAREALRHPF 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	109/352 (31%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
FC2	NP_194205.1	PKc_CLK	85..423	CDD:271036	112/368 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810