DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and AT3G17750

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_188402.1	Gene:	AT3G17750 / 821043	AraportID:	AT3G17750	Length:	1138	Species:	Arabidopsis thaliana

Alignment Length:	525	Identity:	137/525 - (26%)
Similarity:	223/525 - (42%)	Gaps:	132/525 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CSGLGAGLSVRATSFYGDQTVTATTD------------GTRHQEQQQQQLQQQQQQHILRQPATS 78
            |||..:..::|...   |:.|.::.:            |..|:|:.:::.....::    .|.||
plant   713 CSGSSSERNLRDMD---DEKVASSRNSSPSALSHSSDTGREHKEEDEEETSHGPEE----DPGTS 770

  Fly    79 ASTSSVAAAATSKRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPI 143
            .....  |....::.||........:::|
plant   771 FEDED--AIVVQEQVRQIQAQEQDFETFN------------------------------------ 797

  Fly   144 SSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVK 208
              ||..|.|              .|:....|.::.:|.:.|   ::..|.|.|.||...|.:.::
plant   798 --LKIVHRK--------------NRTGFEEDKNFHVVLNSV---IAGRYHVTEHLGSAAFSKAIQ 843

  Fly   209 CWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQEN-ADEFNFVRAFECFQHKNHTCLVFEM 272
            .....|...|.:||:||:..:..|...|:.:|..::|.: ||:::.:|.::.|..:.|..:|.|:
plant   844 AHDLHTGIDVCVKIIKNNKDFFDQSLDEIKLLKYVNQHDPADKYHLLRLYDYFYFREHLLIVCEL 908

  Fly   273 LEQNLYDFLKQNKFSPLPLKYIRPILE----QVLTALLKLKQLGLIHADLKPENIMLVDPVRQPY 333
            |:.|||:|.|.|:.|...:.:..|.|:    |.|.||..|..|||||.|||||||::....|  .
plant   909 LKANLYEFQKFNRESGGEVYFTMPRLQSITIQCLEALNFLHGLGLIHCDLKPENILIKSYSR--C 971

  Fly   334 RVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSS 398
            .:||||.||:...:..:| :|:|||.|||||:|||||:.:.||:|||||::|||..|..|:...|
plant   972 EIKVIDLGSSCFETDHLC-SYVQSRSYRAPEVILGLPYDKKIDIWSLGCILAELCTGNVLFQNDS 1035

  Fly   399 EFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEA-ETNTKSKEARKYI 462
            ....:..:....|...:.||.....|.|:|               |:.|.. |.|.:|
plant  1036 PATLLARVIGIIGSIDQEMLAKGRDTCKYF---------------TKNHLLYERNQES------- 1078

  Fly   463 FNCLDDIGQVNVPTDLEGGQLLAEKTDRRE--------FIDLLKRMLTIDQERRLTPAEALNHSF 519
                         .:||  .|:.:|:..|.        |||.:..:|.:|.::|.:..|||.|.:
plant  1079 -------------NNLE--YLIPKKSSLRRRLPMGDQGFIDFVAYLLQVDPKKRPSAFEALKHPW 1128

  Fly   520 TRLTH 524
              ||:
plant  1129 --LTY 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	111/341 (33%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
AT3G17750	NP_188402.1	PKc_DYRK_like	827..1129	CDD:271035	111/343 (32%)
AT3G17750	NP_188402.1	S_TKc	827..1129	CDD:214567	111/343 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24058
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910