Protein Alignment Hipk and hipk3

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: XP_012816854.1
• Gene: hipk3 / 780181
• XenbaseID: XB-GENE-1010053
• Length: 1217
• Species: Xenopus tropicalis
• Alignment Length: 1246
• Identity: 475/1246 - (38%)
• Similarity: 601/1246 - (48%)
• Gaps: 297/1246 - (23%)

  Fly   151 TKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTS 215
            |.|||:|       .||:|::..||||||:.||||.|:...||||:||||||||||||||:|||:
 Frog   190 TVVATTG-------TSKQSTASGDGDYQLMLHEVLCSVKNTYEVLDFLGRGTFGQVVKCWRRGTN 247

  Fly   216 EIVAIKILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDF 280
            |:||:||||||||||||||||:.||:|||.|||||||||||:|||||:|||||||||||||||||
 Frog   248 EVVAVKILKNHPSYARQGQIEMGILARLSNENADEFNFVRAYECFQHRNHTCLVFEMLEQNLYDF 312

  Fly   281 LKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASH 345
            ||||||||||||.||.||:||.|||.|||.||||||||||||||||||||||||||||||||||:
 Frog   313 LKQNKFSPLPLKVIRAILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASY 377

  Fly   346 VSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQ 410
            ||||||:||||||||||||:||||||||||||||||||:||||||||||||:.|:||||||||||
 Frog   378 VSKTVCSTYLQSRYYRAPEVILGLPFCEAIDMWSLGCVIAELFLGWPLYPGAQEYDQIRYISQTQ 442

  Fly   411 GLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVP 475
            |||.:.::|:.:|||:||.|:.|:.||.|||||.|||||||..||||.||||||.||:|..||:.
 Frog   443 GLPGDSLINAGTKTSRFFCREPDAPYPSWRLKTLEEHEAETGIKSKETRKYIFNNLDEIVHVNMM 507

  Fly   476 TDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQM 540
            .||:|..|:|||.|||||:.|||:||.||.::|::||:.|:.||..:.||:|:.:.|:||:...:
 Frog   508 VDLDGSDLMAEKADRREFVALLKKMLMIDADKRISPADTLSQSFITMKHLLDFPHSNHVKSCFYI 572

  Fly   541 MEVCRR----GDF--HT----VQPASTLVTNFVPSSTENMT--FTINNQ-LTSQVQRLVRDGRPL 592
            |:||:.    ||.  |.    |:|.::  || :.|.:...|  .||..| ||:....::..|.||
 Frog   573 MDVCKARPNVGDTANHNKTSIVRPITS--TN-IGSMSAGFTKIGTIRGQALTTSGHSVIHHGIPL 634

  Fly   593 AYEGLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMP----SPTKHVVVGSATMQPPL 653
            .             |...|....|:||..|   |||||:.|.||    .||.:.|.....:....
 Frog   635 Q-------------AGSAPFGCNDAFQQTL---ILCPPAIQGMPPNHGKPTSYSVRVDNALPLVT 683

  Fly   654 QVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQ---APAHSLIV 715
            |.|            .::|...:..:||.       || ..|.|..|||:|.|.   ||..|.:.
 Frog   684 QAP------------AIQPLQIRAGVLTQ-------AW-SNGTQPILVPAWQQMTTIAPTASSLA 728

  Fly   716 DSTPLFNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPP 780
            ..| :...:.:          .|..|..|     .||.|        ....:.|:.......|.|
 Frog   729 SDT-MAGPQRL----------GDWGKVIP-----HGNHY--------NSMIIQPIITNQMTLSAP 769

  Fly   781 HQQRYQRAAHVSPQYHAHHN---CNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPV 842
            .......|..|.||..|:..   |                       .|.:|.......|:  ||
 Frog   770 QPISLGIAHVVWPQPAANKRNKLC-----------------------QNRINAIQDIVVHN--PV 809

  Fly   843 AHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQ---------HGQQPHPQSSQHPQHV 898
            . |.|       .|||:.|.......|:     |...|::         :.|.|.|.:|..
 Frog   810 V-ASP-------KIVSSENTRAEESSAL-----PQDNHEEKEEEQSSSNNTQGPAPDTSIQ---- 857

  Fly   899 KQPTITIHDTPSPT-AVITISDSEDEGGEAGGAQVPVLKQ-RAHAQSQTSGSLLQ----HAPSSS 957
            :|..|.|.|:|||| :||||:...||...   ||...|:: :......|..|.|.    .:|.|:
 Frog   858 QQQAIVIGDSPSPTVSVITINSDTDEDDP---AQTLSLRECKRSLDCDTCQSALNVCSLSSPDST 919

  Fly   958 CSRSSAHQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAAVGSPKH----HHHQQQQQPAPP 1018
            .|.||:.|. .|.|.:::.   :..|.:||       :......|||..    |....:......
 Frog   920 LSTSSSGQS-SPSPCKRRN---SISDDEPE-------SGCDTVNGSPSSDSSGHDSPFKNSFVRD 973

  Fly  1019 PQQQQQQYQPQPPPQQ--VLPQPQPSIKYEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASLPH 1081
            ..|..:...|:....:  |.....|.|:.|..|....|:                ....:...|.
 Frog   974 SNQNTESRTPEKTDSKPAVCTVVVPPIRIENRQFNSHRV----------------SNKDTVCYPV 1022

  Fly  1082 IPTKQEPAEFYPEYAAAPPQQLDTKRSSWAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSVAP 1146
            |..:..|....                  .|.|.||....|..|...:                |
 Frog  1023 IKGRSAPGRIN------------------HPNSLGSRQQKLASAFQHQ----------------P 1053

  Fly  1147 PLAHSKSSSASSSSSISAATAAAAAAAAAAAASVGPPSWG------PPQVYRQPSQPPPGSVGLP 1205
            ||.:||.....|                      |...|.      ..|.|.||
 Frog  1054 PLNYSKVQHFGS----------------------GHQEWNGNYGHMRQQAYMQP----------- 1085

  Fly  1206 GSTQPPPSSVAPHPHHHSHGH------HHHQAG-TPLGGSP-----------SSTAAAALLQPDI 1252
                    :||.||....||.      |.|.|| |.:||.|           ||.|..|.|....
 Frog  1086 --------TVASHPFTLQHGSPTHSALHAHLAGSTHIGGQPAILSYPPSASLSSAAPVAHLLASP 1142

  Fly  1253 YAQGDIYRRPTVFVSQAAPS---YAYA---NRAVVAPPPAHNSSSRQVIPSHPLPAHIQIPTQYS 1311
            .....|.:.||..:|.  ||   :..|   |..::..|..|.:..:.:.|||   ::|.....|:
 Frog  1143 CTSRPILQHPTYSLSH--PSGIVHQVAVGINPRLLPSPTIHQTQFKPIFPSH---SYITASPAYA 1202

  Fly  1312 QFGPLSPAQVA 1322
            .| |:||.:::
 Frog  1203 GF-PMSPTKLS 1212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	259/327 (79%)
		PHA03378	<1080..1327	CDD:223065	59/273 (22%)
hipk3	XP_012816854.1	STKc_HIPK3	223..552	CDD:271131	259/328 (79%)