DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and dyrk1a

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	XP_012812685.1	Gene:	dyrk1a / 779733	XenbaseID:	XB-GENE-1017105	Length:	771	Species:	Xenopus tropicalis

Alignment Length:	976	Identity:	248/976 - (25%)
Similarity:	372/976 - (38%)	Gaps:	297/976 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FVDYAVAGGGGSGFC-----------SGLGAGLSVRATSFYGDQTVTATTDGTRHQEQQQQQLQQ 65
            |:.:.:.||..|. |           |...|||.:.....:..|         ::.:::||.|..
Frog    17 FISHLMIGGETSA-CKPSSVRLAPSFSFHAAGLQMAGQMSHSHQ---------QYSDRRQQNLND 71

  Fly    66 QQ----------QQHI---------LRQPATSASTS-SVAAAAT---------SKRKRQTDCDCG 101
            ||          ||.:         .|.|||:.... ||....|         :|:||:
Frog    72 QQASALPYNDQIQQPLPNQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRR------ 130

  Fly   102 CVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPS 166
                    |    ||                 |.|.|         ::|.|            ..
Frog   131 --------H----QQ-----------------GQGDD---------SSHKK------------ER 145

  Fly   167 KRSSSGADG---DYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPS 228
            |..:.|.|.   ||.:...|   .....||:...:|:|:||||||.:.|...|.|||||:||..:
Frog   146 KVYNDGYDDDNYDYIVKNGE---KWMDRYEIDSLIGKGSFGQVVKAYDRAEQEWVAIKIIKNKKA 207

  Fly   229 YARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 292
            :..|.||||.:|..:::.:.: ::..|.....|..:||.|||||||..||||.|:...|..:.|.
Frog   208 FLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLN 272

  Fly   293 YIRPILEQVLTALLKL--KQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYL 355
            ..|...:|:.||||.|  .:|.:||.|||||||:|.:|.|.  .:|::||||:..:.:.:.. |:
Frog   273 LTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YI 334

  Fly   356 QSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNS 420
            |||:||:||::||:|:..|||||||||::.|:..|.||:.|::|.||:..|.:..|:|..|:|:.
Frog   335 QSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMSKIVEVLGIPPAHILDQ 399

  Fly   421 ASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLA 485
            |.|..|||.:..:.|   |.||.|::.:.|  .|....|| :.|.|      .|.|...||:...
Frog   400 APKARKFFEKMPEGT---WNLKKTKDGKKE--YKPPGTRK-LHNLL------GVETGGPGGRRGG 452

  Fly   486 EK----TDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRR 546
            |.    .|..:|.||:.|||..|.:.|:.|..||.|||.:.|........|:|..|..|
Frog   453 ESGHTVADYLKFKDLILRMLDYDAKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAM------ 511

  Fly   547 GDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQIYNG----RSVA 607
                 .|..|:..|:...||:...:.|.|:            ||..:.......::|    .:|.
Frog   512 -----EQSQSSGTTSSTSSSSGGSSGTSNS------------GRARSDPTHQHRHSGGHFTAAVQ 559

  Fly   608 RQYPQTRTDSFQHQLVSNILCPPSYQTMPSPTKHVVVGSATMQPPLQVPPQQYVNVPVPVSMVEP 672
            ....:|.:...:.|.      ||.:....:||:..:......:....|||.|. |||
Frog   560 AMDCETHSPQVRQQF------PPGWTVPEAPTQVTIETHPVQETTFHVPPSQQ-NVP-------- 609

  Fly   673 TSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIYPKHHLNLPRN 737

Frog   610 ----------------------------------------------------------------- 609

  Fly   738 DLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVK-ESSPPHQQRYQRAAHVSPQYHAHHNC 801
                    ||...|:.:....|.....|.:...:.|.: .:||......|.:..|.   |:||:
Frog   610 --------HHHGNGSHHHHHHHHHHHGQHVLSNRTRTRIYNSPSTSSSTQDSMDVG---HSHHS- 662

  Fly   802 NYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGA 866
                    ..|..|...||:.|||:  .|:..:..:.:.|||              :|....|..
Frog   663 --------MTSLSSSTTSSSTSSSS--TGNQGNQAYQNRPVA--------------ANTLDFGQN 703

  Fly   867 GGAVVYQQPPAHAHQQHGQQPHP----QSSQHPQH-VKQPTITI------HDTP--------SPT 912
            |...|.....::..|:.|...||    .::..|.| |.:..:|:      .|:|        ||.
Frog   704 GTMDVNLTAFSNPRQETGITGHPDYQYSANTGPGHYVTEGHLTMRQGMDREDSPMTGVCVQQSPV 768

  Fly   913 A 913
            |
Frog   769 A 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	136/334 (41%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
dyrk1a	XP_012812685.1	PKc_DYRK1	160..496	CDD:271128	139/353 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940