Protein Alignment Hipk and CLK4

DIOPT Version :9

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_065717.1
• Gene: CLK4 / 57396
• HGNCID: 13659
• Length: 481
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 128/464 - (27%)
• Similarity: 206/464 - (44%)
• Gaps: 115/464 - (24%)

  Fly    80 STSSVAAAATS-KRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPI 143
            |.|||.:..:| ||||...|         |||
Human   102 SKSSVRSRRSSPKRKRNRHC---------SSH--------------------------------- 124

  Fly   144 SSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYS---LSAEYEVLEFLGRGTFGQ 205
            .|...:|.:              |||.|..|.:   ..|.:..|   |.|.||:::.||.|.||:
Human   125 QSRSKSHRR--------------KRSRSIEDDE---EGHLICQSGDVLRARYEIVDTLGEGAFGK 172

  Fly   206 VVKCWKRGTSEI-VAIKILKNHPSYARQGQIEVSILSRLSQENADE-FNFVRAFECFQHKNHTCL 268
            ||:|...|...: ||:||:||...|....:.|:.:|..|:..:.:. |..|:..|.|.|..|.|:
Human   173 VVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCI 237

  Fly   269 VFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLV------- 326
            |||:|..:.|||:|:|.|.|..:.:||.:..|:..::..|....|.|.|||||||:.|
Human   238 VFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVK 302

  Fly   327 --DPVRQPYR------VKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCV 383
              ..:::..|      :||:|||||::..:. .:|.:.:|:|||||:||.|.:.:..|:||:||:
Human   303 YNSKMKRDERTLKNTDIKVVDFGSATYDDEH-HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCI 366

  Fly   384 VAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHE 448
            :.|.:||:.::......:.:..:.:..|...:||:....|...|.:..:|     |     :||.
Human   367 LIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLD-----W-----DEHS 421

  Fly   449 AE---TNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLT 510
            :.   ...:.|..::::. |.|:                    :..:..||::|||..|..:|:|
Human   422 SAGRYVRRRCKPLKEFML-CHDE--------------------EHEKLFDLVRRMLEYDPTQRIT 465

  Fly   511 PAEALNHSF 519
            ..|||.|.|
Human   466 LDEALQHPF 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	104/348 (30%)
		PHA03378	<1080..1327	CDD:223065
CLK4	NP_065717.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..143		20/96 (21%)
		PKc_CLK1_4	146..475	CDD:271115	108/361 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810