Protein Alignment Hipk and hipk1b

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: XP_009304049.2
• Gene: hipk1b / 572323
• ZFINID: ZDB-GENE-140324-1
• Length: 1126
• Species: Danio rerio
• Alignment Length: 1345
• Identity: 492/1345 - (36%)
• Similarity: 620/1345 - (46%)
• Gaps: 432/1345 - (32%)

  Fly    85 AAAATSKRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAG--------AGSVGSKAGSGPGPDGIG 141
            ||.:|...:|.:        |..:||......:|.::.|        ...|.|..|.|.|...:.
Zfish    73 AADSTGSLQRGS--------SRRTSHNNTHHSESHSSRGHRYGVKRKNEEVESSGGGGSGSSSVQ 129

  Fly   142 PISSLKTAHTKVATSGGHANTQ------PPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGR 200
            .:..|........|.|.....|      |.:|.|||..:|||||||||:|.|:|..|||||||||
Zfish   130 ILEELSAPAFSTQTGGAGTTGQSIPHSAPTTKSSSSNGEGDYQLVQHEILCSVSNSYEVLEFLGR 194

  Fly   201 GTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAFECFQHKNH 265
            ||||||.|||||||:|||||||||||||||||||||||||:|||.||||||||||::||||||.|
Zfish   195 GTFGQVAKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILNRLSAENADEFNFVRSYECFQHKGH 259

  Fly   266 TCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVR 330
            |||||||||||||||||.:|||||||::|||||:||.|||:|||.||||||||||||||||||:|
Zfish   260 TCLVFEMLEQNLYDFLKHSKFSPLPLRHIRPILQQVATALMKLKCLGLIHADLKPENIMLVDPIR 324

  Fly   331 QPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYP 395
            ||||||||||||||||||.||:|||||||||||||||||||||||||||||||:|||||||||||
Zfish   325 QPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYP 389

  Fly   396 GSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARK 460
            |:||:|||||||||||||.|::|::.:|||:||.|..||:||.|||||..|||:|...|||||||
Zfish   390 GASEYDQIRYISQTQGLPPEYLLSAGTKTSRFFNRGPDSSYPLWRLKTPSEHESEMGIKSKEARK 454

  Fly   461 YIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHL 525
            ||||||||:.|||:|..|||..|||||.||||.||||||||.:|.::|:||.:.|.|.|..::||
Zfish   455 YIFNCLDDMMQVNLPNHLEGTDLLAEKADRRELIDLLKRMLRLDADKRITPTKTLAHPFVTMSHL 519

  Fly   526 VDYVYCNNVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDG- 589
            :::.:.::||:..|.|::|:|.:.......:....|.||.:..|:|.|.::||....|.....|
Zfish   520 LNFPHSSHVKSCFQNMDICKRRNSSFDSGKTLFAANTVPGTAGNLTVTFSSQLNQHSQVPSAGGA 584

  Fly   590 ------RPLAYE-------GLYQIYNGRSVARQYPQT----RTDSFQHQLVSNILCPP-SYQTMP 636
                  :|..|:       ||.|    .|:..|...|    :|:.||..|   |:||| :.|.:|
Zfish   585 VPLLNYQPALYQQATINIPGLAQ----PSIPLQTRSTQLCAQTEPFQQTL---IVCPPTTIQGLP 642

  Fly   637 SPTKH-----------VVVGSATMQPPLQVPPQQYVN---VPVPVSMVEP--------------- 672
            |..|.           .||.......|||:.|.....   .|:.|:.:.|
Zfish   643 SSNKTSSYPVRMENGVPVVQQNQSSQPLQLQPSMLTQGSCTPLMVATLHPHPAGVASQYPLPLAL 707

  Fly   673 --TSGQRMLLTNRVQASGV--AWPQTGRQMALVPSWPQQAP-------AHSLIVDSTPLFNVEEI 726
              .:|:..||.   |.:.|  ||| .|.|..|:||..||.|       :|..:|:.:||
Zfish   708 GCGAGRPALLE---QTATVLQAWP-AGTQQILIPSAWQQVPGMTIHNSSHQPVVNQSPL------ 762

  Fly   727 YPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPPHQQRYQRAAHV 791
                ...|..|..::.|         |:|.                   ..|..|....|:..|:
Zfish   763 ----QALLSENSTQQTS---------SWRA-------------------SQSGQHNGVVQQNPHI 795

  Fly   792 SPQYHAHHNCNYGNGSGYSASAGSVVASSAASSSN----IVNGSSSSSHHHHVPVAHAQPYSSSS 852
            ....:..|:.|.|             |::|..|.|    |...:||||     .:..:|.||:
Zfish   796 LSGINPTHSLNRG-------------ATTATRSQNKRSRICCDTSSSS-----ALVASQSYSA-- 840

  Fly   853 GHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHVKQPTITIHDTPSP-TAVIT 916
                              :..||                           |.|.||||| .:|||
Zfish   841 ------------------LLTQP---------------------------IIISDTPSPAVSVIT 860

  Fly   917 I-SDSEDEGGEAGGAQVPVLKQRAHAQSQTSGSLLQHAPSSSCSRSSAHQQPHPHPQQQQQQQIN 980
            | |||||
Zfish   861 IHSDSED---------------------------------------------------------- 867

  Fly   981 YGDHDPEDARRRHHAAAAAAVGSPKHHH--------HQQQQQPAPPPQQQQQQYQPQPPPQQVLP 1037
                  ||.|:.|.|:.     .|.|..        |......|.|                :.|
Zfish   868 ------EDERKFHPASC-----GPSHRTNVISCLTVHDSDSSTASP----------------LTP 905

  Fly  1038 QPQPSIKYEPGQSQKKRILAMAQSECGYQPQVPSQP---SSSASLPHIPTKQEPAEFY--PEYAA 1097
            :||..  :...||.:     :|:|.....|.|.:||   |.||.:|  |....|..:|  |:.||
Zfish   906 KPQNG--HIGLQSSR-----LAKSLAVVAPTVKTQPVESSISAKIP--PALGLPQNYYMKPKRAA 961

  Fly  1098 APPQQLDTKRSSWAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSVAPPLAHSKSSSASSSSSI 1162
            |...|          :|||..:|                            .|.:..|.|...::
Zfish   962 ATRHQ----------SSSGGSIS----------------------------EHQQEPSRSQPLNL 988

  Fly  1163 SAATAAAAAAAAAAAASVGPPSWGPPQVYRQPSQPPPGSVGLPGS-------TQPPPSSVAPHPH 1220
            |..|.:::.|                        ||||.:  |.|       |.||.||
Zfish   989 SQTTVSSSQA------------------------PPPGVI--PSSSSLRRQHTYPPASS------ 1021

  Fly  1221 HHSHGHHHHQAGTPLGGSPSSTAAAALLQPDIYAQGDIYRRPT-----VFVSQAAPSYAYANRAV 1280
            |:.           |..:||.|:.     |.:|.    |..|.     :.|..::||       :
Zfish  1022 HYC-----------LQEAPSFTST-----PSLYT----YPNPASHMEHLLVQGSSPS-------I 1059

  Fly  1281 VAPPPAHNSSSRQVIPS-------HPLPAHIQIPTQYSQFGPLSP 1318
            .|||..|.::|  :||.       |.:.||      |.|..|..|
Zfish  1060 HAPPTTHYAAS--LIPKDSIGGVVHGISAH------YQQHYPAHP 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	267/327 (82%)
		PHA03378	<1080..1327	CDD:223065	56/260 (22%)
hipk1b	XP_009304049.2	None