Protein Alignment Hipk and hipk1a

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: XP_009295328.2
• Gene: hipk1a / 572042
• ZFINID: ZDB-GENE-081031-101
• Length: 1124
• Species: Danio rerio
• Alignment Length: 1372
• Identity: 484/1372 - (35%)
• Similarity: 629/1372 - (45%)
• Gaps: 433/1372 - (31%)

  Fly    43 DQTVTATTDGTRHQEQQQQQLQQQQQQHILRQPATSASTSSVAAAATSKRKRQTDCDCGCVDSYN 107
            :|||....|.|..                :.:|::|:|:||                       .
Zfish    79 EQTVVRAADSTGS----------------VPEPSSSSSSSS-----------------------T 104

  Fly   108 SSH-GPPVQQDSSAAAG---AGSVGSKAGSGPGPDGIGPISSLK--TAHTKVATSGGHANTQ--- 163
            ||| |...:.:|....|   ..|:..|:......|.:..:..|.  ....:||..||:|..|
Zfish   105 SSHRGKDARSNSLTCEGYQKRASLKRKSEEVDSSDSVQILEELSAPVLPNRVAGGGGNATAQSIA 169

  Fly   164 ---PPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKN 225
               ..:|.|:|.::|||||||||:|.|:|..|||||||||||||||.|||||||:||||||||||
Zfish   170 HSTSTTKSSNSHSEGDYQLVQHEILCSVSNSYEVLEFLGRGTFGQVAKCWKRGTNEIVAIKILKN 234

  Fly   226 HPSYARQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP 290
            |||||||||||||||||||.||||||||||::|||||||||||||||||||||||||.:|||||.
Zfish   235 HPSYARQGQIEVSILSRLSTENADEFNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKHSKFSPLL 299

  Fly   291 LKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYL 355
            ||.|||:|:||.|||:|||.||||||||||||||||||:|||||||||||||||||||.||:|||
Zfish   300 LKCIRPVLQQVSTALMKLKSLGLIHADLKPENIMLVDPIRQPYRVKVIDFGSASHVSKAVCSTYL 364

  Fly   356 QSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNS 420
            ||||||||||||||||||||||||||||:||||||||||||:||:||||||||| |||.|::|::
Zfish   365 QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTXGLPAEYLLSA 429

  Fly   421 ASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLA 485
            .:|||:||:|..||:||.|||||..||||:...|||||||||||||||:.|||: |:|||..:||
Zfish   430 GTKTSRFFHRGPDSSYPLWRLKTPAEHEADFGIKSKEARKYIFNCLDDMMQVNM-TNLEGTDILA 493

  Fly   486 EKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGDFH 550
            ||.||||||||||:|||:|.::|:||.:.|||.|..:|||:.:.:.::||:..|.|::|:|....
Zfish   494 EKADRREFIDLLKKMLTLDADKRITPTKTLNHPFVTMTHLLHFPHSSHVKSCFQNMDICKRRCTA 558

  Fly   551 TVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLA---------YE-GLYQ--IYNG 603
            .....:...::..||:..|:|.|.::||....|.....|:.|:         |: ||||  ..|.
Zfish   559 FDNNKNLFSSHNGPSAAANLTVTFSSQLNQHSQMASTGGQSLSLSSNVPLLNYQPGLYQQATINI 623

  Fly   604 RSVARQ-YP-QTR-------TDSFQHQLVSNILCPPSYQTMPSPTKHV-----------VVGSAT 648
            ..:|:| .| |.|       |:.||..|   |:|||:.|.:.:..||.           :|....
Zfish   624 PGLAQQSVPLQARPTQLCAQTEPFQQTL---IVCPPTIQGLQTTNKHTGYPVRMDNSVPIVPQNQ 685

  Fly   649 MQPPLQVPPQ---QYVNVPV------------PVSMVEP-TSGQRMLLTNRVQASGVAWPQTGRQ 697
            ...||.:.|.   |:::..:            |:::..| |...|.|..:.....|  || .|.|
Zfish   686 STQPLHIQPSMLTQFLHTSLYPFPNQSNSSSTPLTLRLPLTLSSRHLEQSATMLQG--WP-AGTQ 747

  Fly   698 MALVPSWPQQAPAHSLIVDSTPLFNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKK 762
            ..|:||..||....::...|.|:                  |..:||...:...||
Zfish   748 QILIPSSWQQMSGMAMHNPSQPV------------------LSTDSPMSSLLSDNS--------- 785

  Fly   763 EHQQLSPVKKRVKESSPPHQQRYQRAAHVSPQYHAHHNCN---YGN--GSGYSASAGSVVASSAA 822
                              :||...|..|..       .|:   .|:  |...:..|....|:||.
Zfish   786 ------------------NQQNSWRGRHGG-------QCDGTQQGSVQGRNVNTQASHAGAASAR 825

  Fly   823 SSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQP 887
            |..|.:..|......:.|....:|..:|::.|          |.|.|
Zfish   826 SQQNTLKRSKVRHADNRVRPTSSQQQASAAAH----------GCGDA------------------ 862

  Fly   888 HPQSSQHPQHVKQPTITIHDTPSP-TAVITI-SDSEDEGGEAGGAQVPVLKQRAHAQSQTSGSLL 950
                       .|| |.|.||||| .::||| ||:|||..
Zfish   863 -----------SQP-IIISDTPSPAVSIITIHSDTEDEDD------------------------- 890

  Fly   951 QHAPSSSCSRSSAHQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQP 1015
            :..|..|||                             ..:|.:..:...|       |..|..
Zfish   891 RKIPPESCS-----------------------------VNQRTNVISCVTV-------HDSQDS- 918

  Fly  1016 APPPQQQQQQYQPQPPPQQVLPQPQPSIKYEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASLP 1080
                                                                      .||.|.|
Zfish   919 ----------------------------------------------------------DSSTSTP 925

  Fly  1081 HIPTKQEPAEFYPEYAAAPPQQLDTKRSSWAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSVA 1145
            ..|.:|                     ||:...::          |.|       .::.|.|||.
Zfish   926 ISPKRQ---------------------SSFIENNT----------HSK-------SLAVVTPSVK 952

  Fly  1146 PPLAHSKSSSASSSSSISAATAAAAAAA---AAAAASVGPP--------SWGPPQVYRQPSQPPP 1199
            ..|..:.|...|::||..:....|:.::   ..||::...|        |.|.| :.|||:.||.
Zfish   953 TQLWDAASGEQSTNSSGKSKKGMASQSSDRHQRAASNRSQPLNLSQAQQSMGGP-LRRQPTYPPT 1016

  Fly  1200 GSVGLPGSTQPPPSSVAPHPHHHSHGHHHHQAGTPLGGSPSSTAAAALLQPDIYAQGDIYRRPTV 1264
            |.                     ||.:..|:|.  |.||.||                :|..|
Zfish  1017 GP---------------------SHSYRLHEAS--LFGSASS----------------LYAYP-- 1040

  Fly  1265 FVSQAAPSYAYANRAVVAPPPAHN----SSSRQVIPSHPLPAHIQIPTQYSQFGPLSPA------ 1319
                |:.:.|..::||   ...||    ||||....:.|..|.:.:..:.|..|.:..|
Zfish  1041 ----ASAALASVSQAV---DQLHNSSSTSSSRHTRTAGPYSASLSLLQKNSAMGVMCHASAPYQQ 1098

  Fly  1320 QVAASKH 1326
            |::|..:
Zfish  1099 QLSAQSY 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	268/327 (82%)
		PHA03378	<1080..1327	CDD:223065	57/268 (21%)
hipk1a	XP_009295328.2	None