Protein Alignment Hipk and hipk3b

DIOPT Version :9

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_001073628.1
• Gene: hipk3b / 569156
• ZFINID: ZDB-GENE-030131-82
• Length: 1261
• Species: Danio rerio
• Alignment Length: 1389
• Identity: 502/1389 - (36%)
• Similarity: 655/1389 - (47%)
• Gaps: 328/1389 - (23%)

  Fly    47 TATTDGTRHQE-----QQQQQLQQQQQQHILRQPATSASTSSVAAAATSKRKRQTDC-------- 98
            ||...|.|.|.     |||::....|::....|......:|....||...|...:|.
Zfish    81 TAAVQGVRRQHTITVAQQQKRGASSQEKESEHQDKGRVCSSGATRAAGRGRGVGSDSQEEGGGGQ 145

  Fly    99 ----------------DCGCVDSYNSSHGPPVQQDSSAAAGAGS--------------VGSKAGS 133
                            |||..|..:|||...:::.|......||              :.|..|:
Zfish   146 GGVDEGGGGEDEGDQEDCGGFDLNDSSHRCGLKRKSGELENLGSTMQIVEDLSMLPAMLQSNVGN 210

  Fly   134 GP--GPDGIGPISSLKTAHTKVATSGGHANTQPPSKR--SSSGADGDYQLVQHEVLYSLSAEYEV 194
            .|  .|..:|               ||      |:|:  .|...||||||||||:|.||...|||
Zfish   211 PPVAVPQAVG---------------GG------PAKQGGGSGNGDGDYQLVQHEMLCSLKNTYEV 254

  Fly   195 LEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAFEC 259
            |:||||||||||||||||||.:|||:|||||||||||||||||.||:|||.|||||.|.||||||
Zfish   255 LDFLGRGTFGQVVKCWKRGTKDIVAVKILKNHPSYARQGQIEVGILARLSNENADEHNLVRAFEC 319

  Fly   260 FQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIM 324
            |||::||||||||||||||||||||||||||||.|||||:||.|||.|||.:|||||||||||||
Zfish   320 FQHRSHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKGMGLIHADLKPENIM 384

  Fly   325 LVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFL 389
            ||||||||||||||||||||||||.||:|||||||||||||||||||||||||||||||:|||||
Zfish   385 LVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL 449

  Fly   390 GWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTK 454
            |||||||:.|||||||||||||||.||:||..:|||:||.|:.||.|..||||:|||||.||..|
Zfish   450 GWPLYPGALEFDQIRYISQTQGLPGEHLLNVGTKTSRFFCRESDSPYATWRLKSTEEHETETGLK 514

  Fly   455 SKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSF 519
            |||||||||:|||||..||:..:|||..|||||.||.||:.|||:||.||.|.|:.|::||:|.|
Zfish   515 SKEARKYIFSCLDDIAHVNLVMNLEGCDLLAEKVDRAEFVALLKKMLLIDAEERIAPSDALSHPF 579

  Fly   520 TRLTHLVDYVYCNNVKASVQMMEVC--RRGDFHTVQPASTLVTNFVPS--STENMTFT------I 574
            ..:.||:|:.:.|:||:...:|:||  |.|.:.:...........|||  :..|:|..      |
Zfish   580 VTMQHLLDFPHSNHVKSCFHIMDVCCSRPGSYESHSRTKAQFVRTVPSTGAASNLTLPFCKVTGI 644

  Fly   575 NNQ-LTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMPSP 638
            :.| |.|....::..|.||           ::.:.|:    .||||..|   |||||:.|.:| |
Zfish   645 HTQALASSAPTVMHPGIPL-----------QTGSAQF----GDSFQQAL---ILCPPTIQGLP-P 690

  Fly   639 TKHVVVG-SATMQPPLQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVP 702
            ..:...| |.:|:..:.:..|        .|.::|...:..::|.:      .|....:|: |||
Zfish   691 NPNKPAGYSVSMESTVPLVTQ--------ASAIQPLQIRPGVITQQ------GWSNRAQQI-LVP 740

  Fly   703 SWPQQAPAHSLIVDSTPLFNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSY--RVPRHEKKEHQ 765
            :|||..|...:...:|.|.:.....|:.        |......|  :.||.|  .:|.|:
Zfish   741 TWPQVTPVAPVAPSATTLASEPVAGPQR--------LADWGKVH--SHGNHYSSMMPHHQ----- 790

  Fly   766 QLSPVKKRVKESSPPHQQRYQRAAHVS-PQYHAHHNCNYGNGSGYSASAGSVVASSAASSSNIVN 829
               |:.......| .||......|||. ||                            .::|..|
Zfish   791 ---PLLTNPMAMS-AHQPISIGIAHVVWPQ----------------------------PAANKRN 823

  Fly   830 GSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQ------HGQQPH 888
            ..||:..::.:...::|..|..|...:.|..|....|...||..:..|...::      ..:...
Zfish   824 KPSSNRCNNFMHSTNSQNVSCQSPKMVNSAKNTEEEAADCVVEAESEAVQEEESVCCKAEPEYED 888

  Fly   889 PQSSQHPQHVKQPTITIHDTPSPT-AVITISDSEDEGG--------EAGGA------QVPVLKQR 938
            |..||.    ::.||.|.|:|||. ::|:||...||.|        |..|:      |..:..:|
Zfish   889 PTVSQK----QRQTIVITDSPSPAGSIISISSGTDEDGPDTQKHALECKGSPDCEACQSTLNMER 949

  Fly   939 AHAQSQTSGSLLQHAPSSSCSRSSAHQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAAVGS 1003
            ..:.|....:|...:.:|..|.:|..::|:.....:::...:..|..|.       :.:::...|
Zfish   950 VCSLSSPDSTLSTSSSASEQSSASPCKRPNSMSDDERESGCDTVDGSPA-------SVSSSRADS 1007

  Fly  1004 P----KHHHHQQQQQPAPPPQQQQQQYQP----QPPPQQVLPQPQPSIKYEPGQSQKKRILAMAQ 1060
            |    .:.:...|...|....:.:....|    ..||.:|..:|......||....|.|
Zfish  1008 PFLEATYINDNNQNCKATGSTETESAKLPVRTMVVPPMRVQNEPVGRTVIEPSCPPKGR------ 1066

  Fly  1061 SECGYQPQVPSQPSSSASLPHIPTKQEPAEFYPEYAAAPPQQ--------LDTKRSSWAPTSSGS 1117
              .|...|:|    .|..|.:...|..|| |.|   ..||||        ..:....|    :|:
Zfish  1067 --SGSNRQLP----YSTLLVNRQQKSTPA-FPP---LQPPQQQLFGQVQHYGSSHQEW----NGN 1117

  Fly  1118 GVSALPLAHPKREAPSVAPISYVAPSVAPPLAHSKSSSASSSSSISAATAAAAAAAAAAAASVGP 1182
                  .:|.:.:|            ..||..||.:.:...                      |.
Zfish  1118 ------YSHRRPQA------------FIPPTVHSHTFTLPH----------------------GS 1142

  Fly  1183 PSWGPPQVYRQPSQPPPGSVGLPGSTQP-----PPS----SVAPHPHHHSHGHHHHQAGTPLGGS 1238
            |:        ..:.||...:|:...|||     |||    :.||..|              |..|
Zfish  1143 PT--------HTTHPPQSHLGVHPHTQPALLSYPPSGPLVTNAPMAH--------------LLAS 1185

  Fly  1239 PSST------AAAALLQPDIYAQGDIYRRPTVFVSQAAPSYAYANRAVVAPPPAHNSSSRQVIPS 1297
            |.:|      .|..|..|    .|.:..:.||.:::..||           |..|...  |..|.
Zfish  1186 PGATRNHVFQPAYGLSHP----AGHLLHQVTVGINRLLPS-----------PTIHPQG--QFKPL 1233

  Fly  1298 HPLPAHIQIPTQYSQFGPLSPAQV 1321
            .|..:.|..|. |:.| ||||.::
Zfish  1234 FPPHSFIASPA-YAGF-PLSPTKL 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	266/327 (81%)
		PHA03378	<1080..1327	CDD:223065	56/265 (21%)
hipk3b	NP_001073628.1	STKc_HIPK3	251..580	CDD:271131	266/328 (81%)
		S_TKc	252..580	CDD:214567	266/327 (81%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596085
Domainoid	1	1.000	55	1.000	Domainoid score	I11090
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	631	1.000	Inparanoid score	I820
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38932at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25369
orthoMCL	1	0.900	-	-		OOG6_103159
Panther	1	1.100	-	-	O	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X805
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.890