DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and dyrk4

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	XP_009296230.1	Gene:	dyrk4 / 564976	ZFINID:	ZDB-GENE-091015-3	Length:	644	Species:	Danio rerio

Alignment Length:	370	Identity:	136/370 - (36%)
Similarity:	197/370 - (53%)	Gaps:	50/370 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 PSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSY 229
            |.........|.|..|.|:   .:...|||||.:|:|:||||:||....|:|.|||||::|...:
Zfish   198 PQNAGYDDEHGSYLKVLHD---HIGYRYEVLEVIGKGSFGQVLKCLDHKTNETVAIKIIRNKKRF 259

  Fly   230 ARQGQIEVSILSRLSQENADE-FNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 293
            ..|..:|:.||..:.:.:.|. .|.:...|.|..:||.|:.||:|..|||:.:|:|.|....|..
Zfish   260 HHQALVELKILDAVRRRDRDNCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLGL 324

  Fly   294 IRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSR 358
            ||.....:|..|..|.:..:||.|||||||:|..  |....:||:||||:.:..:.| .||:|||
Zfish   325 IRRFAHSLLKCLQMLHKEKIIHCDLKPENILLSQ--RGQGNIKVVDFGSSCYEQQRV-YTYIQSR 386

  Fly   359 YYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASK 423
            :||:||:|||.|:..|||||||||::|||:.|:||:||.||.:||..|.:..|||....:.:||:
Zfish   387 FYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEIMGLPPNDFVQTASR 451

  Fly   424 TSKFF-----YRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQL 483
            ...||     .|::                  ||:|.|:.|               |:..:...:
Zfish   452 RRLFFDSKGNPRNI------------------TNSKGKKRR---------------PSSKDLASV 483

  Fly   484 LAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFT---RLTHL 525
            |  ||:...|:|.::|.|..|..:|:||.||:.|.:.   ||..|
Zfish   484 L--KTNDPLFLDFIQRCLVWDPTKRMTPDEAMQHEWITEGRLNRL 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	128/333 (38%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
dyrk4	XP_009296230.1	PKc_DYRK4	178..518	CDD:271127	133/360 (37%)
dyrk4	XP_009296230.1	S_TKc	222..518	CDD:214567	128/333 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840