Protein Alignment Hipk and hipk2

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: XP_005159048.2
• Gene: hipk2 / 557551
• ZFINID: ZDB-GENE-031125-4
• Length: 1230
• Species: Danio rerio
• Alignment Length: 1352
• Identity: 510/1352 - (37%)
• Similarity: 641/1352 - (47%)
• Gaps: 400/1352 - (29%)

  Fly    30 GAGLSVRATSFYGDQTVTATTDGTRHQEQQQQQLQQQQQQHILRQPATSASTSSVAAAATSKRKR 94
            |.|...:..|....|:|:....|......|........:|.:| .||.|...  |.|:|:|
Zfish    43 GYGTHSKVYSQNSKQSVSVAPVGINGASLQVSNSSLSYEQALL-FPAGSGHI--VVASASS---- 100

  Fly    95 QTDCDCGCVDSYNSSHGPPVQQDSSAAAG--AGSVGSKAGSGPG--------------------- 136
                                   :|.|||  .||.|| :|||.|
Zfish   101 -----------------------TSGAAGQLLGSTGS-SGSGSGGHNLTRRSTVSLLDTYQRCGL 141

  Fly   137 ---------PDGIGPISSLKTAHTK----------------VATSGGHANTQPPSKRSSSGADGD 176
                     .:|.|..||:.....:                |||:  .|:|...||.|.:.::||
Zfish   142 KRKSEELDNNNGSGSGSSVHVVEEQQPPAPMIQNNVQSGATVATA--TASTTATSKNSGANSEGD 204

  Fly   177 YQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILS 241
            |||:|||||.|::..|||||||||||||||||||||||||||||||||||||||||||||||||:
Zfish   205 YQLLQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILA 269

  Fly   242 RLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALL 306
            |||.|:||::|||||:|||||||||||||||||||||||||||||||||||||||||:||.|||:
Zfish   270 RLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALM 334

  Fly   307 KLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPF 371
            |||.||||||||||||||||||.|||||||||||||||||||.||:|||||||||||||||||||
Zfish   335 KLKSLGLIHADLKPENIMLVDPARQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPF 399

  Fly   372 CEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTY 436
            ||||||||||||:||||||||||||:||:|||||||||||||.|::|::.:||::||.||.||||
Zfish   400 CEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPDSTY 464

  Fly   437 PFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRML 501
            |.|||||.|:|||||..|||||||||||||||:.|||:.|||||..:||||.|||||||||.:||
Zfish   465 PLWRLKTPEDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLAEKADRREFIDLLTKML 529

  Fly   502 TIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRR--GDFHTVQPAST-LVTNFV 563
            |||.::|:||.|.|||.|..:|||:|:.:..:||:..|.||:|:|  ..:.||..:.| .:|:..
Zfish   530 TIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVA 594

  Fly   564 PSSTENMTFTINNQLT---SQVQRLV------------RDGRPLAYE-GLYQIYNGRSVARQYPQ 612
            ||::.|:|.|.||||.   ||...|.            .|...|.|: .||| .:...:|...|:
Zfish   595 PSTSTNLTMTFNNQLNTVHSQATNLAPSSTSATLSLTNPDVSILNYQSALYQ-PSAAPMAAVAPR 658

  Fly   613 T-------------RTDSFQHQLVSNILCPPSYQTM-PSPTKHV-----------VVGSATMQPP 652
            |             |.|.||..|   |:|||.:|.: .||:||.           :|..|....|
Zfish   659 TMPLQPGAPQLCAARPDPFQQAL---IVCPPGFQGLQASPSKHTGYSVRMENAVPIVTQAPGAQP 720

  Fly   653 LQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQ---QAPAHSLI 714
            ||:.|.                    |||.:      |||...:|:.|.|:|.|   .:..|:.:
Zfish   721 LQIQPG--------------------LLTQQ------AWPSGTQQILLPPAWQQLTHTSVQHATV 759

  Fly   715 V-----DSTPLFNVEEIYP--KH-------------HLNLPRNDLKKESPAHHIAKGNSYRVPRH 759
            :     .|.||.|....:|  .|             |:.||.........||.:.:.::.:....
Zfish   760 IPDSMTSSQPLANWRNSHPHGSHYNPIMQQPALLAGHVTLPPQQPLNVGVAHVMRQPSNNQSNSK 824

  Fly   760 EKKEHQ------------QLSPV-----KKRVKESSPPHQQRYQRAAHVSPQYHAHHNCNYGNGS 807
            :.|:||            ...||     .|||||::||      |.|.|.
Zfish   825 KNKQHQMNNRNMSAYDVSSTQPVTSPQRSKRVKENTPP------RCAVVQ--------------- 868

  Fly   808 GYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVY 872
                                 ||          |.:...|..:.:|          ||.||
Zfish   869 ---------------------NG----------PPSTCVPSQTCTG----------GGWGG---- 888

  Fly   873 QQPPAHAHQQHGQQPHPQ--------------------SSQHPQHVKQPT--------------- 902
            :|..:.....|||...|:                    .:.....:||||
Zfish   889 EQACSTTRDHHGQHNPPRQTIIIPDTPSPAVSIITISSDTDEEDDLKQPTNTSTSSKQRKNVISC 953

  Fly   903 ITIHDTP-------SPTAVITISDSEDEGGEAGGAQ------------------VPVLKQRAHAQ 942
            :|:||:|       ||.||    ||...|..|.|..                  :|.||
Zfish   954 VTVHDSPDSDSSNTSPYAV----DSRTNGPNANGYDSKGAVLDNYSNGNPRTIIIPPLK------ 1008

  Fly   943 SQTSGSL----------LQHAPSSSCSRSS--------------------AHQQPHPHPQQQQQQ 977
            ||||.:|          :.|..|:...::|                    ..|:..|||.|||..
Zfish  1009 SQTSENLGECDRLLPDVMNHQNSTYKFKTSNGGFSGNNHTSGGVTGGGAYRQQRTGPHPFQQQPL 1073

  Fly   978 QINYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQQQQQQYQ-PQPPPQQVLPQPQP 1041
            .:         ::.:.|.|.....|      |::||....|....|.||. ...|.......|..
Zfish  1074 NL---------SQAQQHMAVERNGG------HRRQQAYITPTMATQAQYSFHNSPTHTANVHPHL 1123

  Fly  1042 SIKYEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASLPHIPTKQEPAEFYPEYAAAPPQQLDTK 1106
            :..:.|||...            |....|:...|:.::.|:...|..|....::|:.||..:..
Zfish  1124 AAPHLPGQPHL------------YTYTAPAALGSTGTVAHLVASQGSARHAVQHASYPPGIVHQ- 1175

  Fly  1107 RSSWAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSVAP------PLAHSK 1152
                .|.|.|..|...|..|..:.....|..:|::.|.|.      ||:.:|
Zfish  1176 ----VPVSMGHRVLPSPTLHHGQYQAQFAHQTYISASPASTVYTGYPLSPTK 1223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	278/327 (85%)
		PHA03378	<1080..1327	CDD:223065	19/79 (24%)
hipk2	XP_005159048.2	None