DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and Doa

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster

Alignment Length:	578	Identity:	156/578 - (26%)
Similarity:	248/578 - (42%)	Gaps:	133/578 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 GAGLSVRATSFYGDQTVTATTDGTRHQ-----EQQQQQLQQQQQQH--------------ILRQP 75
            ||.|: .:.||...|..||.....:||     :||||..||||.||              :.:||
  Fly  1479 GAPLT-HSASFSSAQRPTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQP 1542

  Fly    76 ATSASTSSVAAAATSKRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDG- 139
            ......:....|.....:.|.       ..|......|..|..:|:||.|. |..||....|:.
  Fly  1543 ERKPLQTFDPYAYPKPNQMQP-------VKYQQQQQHPHTQFQNASAGGGG-GGAAGLQYDPNTN 1599

  Fly   140 -----IGPISS-------------------LKTAHTKVATSGG-----HANTQPPSKRSSSGA-- 173
                 ..|.||                   |:.:::.:....|     |...|....:|:.|.
  Fly  1600 TQLFYASPASSSSNKQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSALGLHF 1664

  Fly   174 ----------DGDYQLVQH--EVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNH 226
                      |.|..|:.|  ::|:.   .|:::..||.||||:|||.........:|:||:||.
  Fly  1665 IETAKPVIQDDADGHLIYHTGDILHH---RYKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNV 1726

  Fly   227 PSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP 290
            ..|....::|::.|.:::|::.. :...|:..:.|.:..|.|:|||||..:::|||::|.:.|.|
  Fly  1727 EKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYP 1791

  Fly   291 LKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDP----------VRQPYRVK-----VIDF 340
            |..:|.:..|:..::..|....|.|.|||||||:.||.          .|:..|||     :|||
  Fly  1792 LDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDF 1856

  Fly   341 GSAS----HVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFD 401
            |||:    |.|     |.:.:|:|||||:||.|.:.:..|:||:||::.||:||..|:......:
  Fly  1857 GSATFDHEHHS-----TIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNRE 1916

  Fly   402 QIRYISQTQG-----LPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKY 461
            .:..:.:..|     :...|.|.|.:||..|::..:|     |      :.::......::..|.
  Fly  1917 HLAMMERILGQIPYRMARNHTLYSKTKTKYFYHGKLD-----W------DEKSSAGRYVRDHCKP 1970

  Fly   462 IFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSF 519
            :|.|                 .|::..|..|...|:|:||..:...|:|..|||:|.|
  Fly  1971 LFLC-----------------QLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPF 2011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	107/353 (30%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	110/369 (30%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	107/353 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460707
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740