DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and prpf4ba

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	XP_017207374.1	Gene:	prpf4ba / 393182	ZFINID:	ZDB-GENE-040426-947	Length:	986	Species:	Danio rerio

Alignment Length:	531	Identity:	154/531 - (29%)
Similarity:	241/531 - (45%)	Gaps:	69/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FCSGLGAGLSVRATSFYGDQTVTATTDGTRHQEQ---QQQQLQQ---QQQQHILRQPATSASTSS 83
            |...|..|:  :|.....|:.|....|.....|:   :|::||:   .|:...:.:.:..:..|.
Zfish   484 FKGSLSEGM--KAEQEDSDEEVLEDYDVDEEDEEALIEQRRLQRLAIMQKYKPVNEDSNMSGLSD 546

  Fly    84 VAAAATSKRKRQTDCD------CGCVDSYNSSHGPPVQQDSSAAAGAGSV---GSKAGSGPGPDG 139
            ..:..:|...|....|      ...|.:|...:....:.:..|.....|.   |:.:...|.||.
Zfish   547 HGSPQSSTHSRSPSPDDILERVAADVKAYEQENLDTFEDNVKAKYSLVSQEKNGANSKKPPAPDM 611

  Fly   140 IGPISSL-----KTAHTKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLG 199
            ......:     .:|..:.|..|......|..:.:.:.|:|.|::...||   |...|.|..:.|
Zfish   612 FTESDDMFAAYFDSARLRAAGIGKDFKENPSLRDNWTDAEGYYRVNIGEV---LDKRYAVYGYTG 673

  Fly   200 RGTFGQVVKC--WKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADE-FNFVRAFECFQ 261
            :|.|..|::.  ..|...| ||:||::|:....:.|..|:..|.:|:..:||: |:.:|.|..|.
Zfish   674 QGVFSNVIRARDLARANQE-VAVKIIRNNEMMQKTGLKELEFLKKLNDADADDKFHCLRLFRHFY 737

  Fly   262 HKNHTCLVFEMLEQNLYDFL-KQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIML 325
            ||.|.|||||.|..||.:.| |..|...|.:|.:|...:|:..||..||:..::|||:||:||:
Zfish   738 HKQHLCLVFEPLSMNLREVLRKYGKDVGLHIKAVRSYSQQLFLALKHLKRCNILHADIKPDNIL- 801

  Fly   326 VDPVRQPYRV-KVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFL 389
               |.:|..: |:.||||||||:......||.||:|||||||:|..:...|||||:||.:.||:.
Zfish   802 ---VNEPKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYT 863

  Fly   390 GWPLYPGSSEFDQIRYISQTQG-LPTEHMLNSASKTS------KFFYRDVDSTYPFWRLKTTEEH 447
            |..|:||.:....::.....:| ||.:.:.....|..      .|.|.:||        |.||
Zfish   864 GKILFPGKTNNHMLKLNMDLKGKLPNKMIRKGLFKDQHFDQNLNFLYTEVD--------KVTE-- 918

  Fly   448 EAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFI----DLLKRMLTIDQERR 508
                  :.|.......|...|:..     |:.|.|.|.|  |:|:.:    |||.::|.:|..:|
Zfish   919 ------REKITVMSTINPTKDLSM-----DMVGRQALPE--DQRKKVGQLKDLLDQILMLDPAKR 970

  Fly   509 LTPAEALNHSF 519
            :|..:||.|.|
Zfish   971 ITINQALQHPF 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	120/344 (35%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
prpf4ba	XP_017207374.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810