Protein Alignment Hipk and Hipk1

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: XP_063138349.1
• Gene: Hipk1 / 365895
• RGDID: 1304941
• Length: 1233
• Species: Rattus norvegicus
• Alignment Length: 1429
• Identity: 532/1429 - (37%)
• Similarity: 654/1429 - (45%)
• Gaps: 432/1429 - (30%)

  Fly     6 PPKASDFVDYAVAGGGGSGFCSGL-----GAGLSVRATS----FYGDQTVTATTDG---TRHQ-- 56
            ||..|           .|.|||..     .:|..|...|    :|........|.|   :.||
  Rat    27 PPSVS-----------SSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQASSSHQVA 80

  Fly    57 ------EQQQQQLQQQQQQHILRQPATSASTSSVAAAAT-----------------------SKR 92
                  ..|...||....:||:   .|:|.:|..||.||                       .||
  Rat    81 NFNIPAYDQGLLLQAPAVEHIV---VTAADSSGSAATATFQSSQTLTHRSNVSLLEPYQKCGLKR 142

  Fly    93 KRQTDCDCGCVDSYNS----SHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKV 153
            |.:.      |||..|    ...||:...:....||.:
  Rat   143 KSEE------VDSNGSVQIIEEHPPLMLQNRTVVGAAA--------------------------- 174

  Fly   154 ATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIV 218
                  ..|...:|.|||..:|||||||||:|.|::..|||||||||||||||.|||||.|.|||
  Rat   175 ------TTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIV 233

  Fly   219 AIKILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQ 283
            ||||||||||||||||||||||||||.|||||:||||::||||||||||||||||||||||||||
  Rat   234 AIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ 298

  Fly   284 NKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK 348
            |||||||||||||||:||.|||:|||.||||||||||||||||||||||||||||||||||||||
  Rat   299 NKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK 363

  Fly   349 TVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLP 413
            .||:|||||||||||||||||||||||||||||||:||||||||||||:||:|||||||||||||
  Rat   364 AVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 428

  Fly   414 TEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDL 478
            .|::|::.:||::||.||.:..||.|||||.||||.||..|||||||||||||||:.|||:.|||
  Rat   429 AEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDL 493

  Fly   479 EGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEV 543
            ||..:||||.||||:|||||:|||||.::|:||.:.|||.|..:|||:|:.:.|:||:..|.||:
  Rat   494 EGTDMLAEKADRREYIDLLKKMLTIDADKRVTPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEI 558

  Fly   544 CRR--GDFHTV-QPASTLVTNFVPSSTENMTFTINNQL-TSQVQRLVRDGRPLAYEGL------- 597
            |:|  ..:.|| |..|...|:..||::.|:|.:.:||| |...|.|......||....
  Rat   559 CKRRVHMYDTVSQIKSPFTTHVAPSTSTNLTMSFSNQLSTVHNQVLSNQASVLASSSTAAAATLS 623

  Fly   598 -----YQIYNGRSVARQYPQ-----------------------TRTDSFQHQLVSNILCPPSYQT 634
                 ..:.|.:|..  ||.                       |:||.||...   |:|||::||
  Rat   624 LANSDVSLLNYQSAL--YPPSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTF---IVCPPAFQT 683

  Fly   635 -MPSPTKH-----------VVVGSATMQPPLQVP------------------PQ------QYVNV 663
             :.:.|||           .:|..|....|||:.                  ||      ||. |
  Rat   684 GLQATTKHSGFPVRMDNAVPLVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYA-V 747

  Fly   664 PVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIYP 728
            |..:|    .:..|..|..:..|...||| .|.|..|:||..||.|..:|.....|...:.|
  Rat   748 PFTLS----CAAGRPALVEQTAAVLQAWP-GGTQQILLPSAWQQLPGVALHNSVQPTAVIPE--- 804

  Fly   729 KHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPPHQQRYQRAAHVSP 793
                                |.|:|           |||:..:..
  Rat   805 --------------------AMGSS-----------QQLADWRNA-------------------- 818

  Fly   794 QYHAHHNCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVS 858
              |:|       |:.||        :.....|.:.|         ||.:|.|||.:....|
  Rat   819 --HSH-------GNQYS--------TIMQQPSLLTN---------HVTLATAQPLNVGVAH---- 853

  Fly   859 NCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQ------------------------------ 893
                       ||.||..:....:..:|..|.||.
  Rat   854 -----------VVRQQQSSSLPSRKNKQSAPVSSTSSLEVLPSQVYSLVGSSPLRTTSSYNSLVP 907

  Fly   894 -HPQHVKQPTITIHDTPS-PTAVITI-SDSEDEGGEAGGAQVPVLKQRAHAQSQTSGSLLQHAPS 955
             ..||  || |.|.|||| |.:|||| ||:::|...........||.|::..|..:   :..:|.
  Rat   908 VQDQH--QP-IIIPDTPSPPVSVITIRSDTDEEEDNKFKPSSSSLKARSNVISYVT---VNDSPD 966

  Fly   956 SSCSRSSAHQQPHPHPQQQQQQQINYGDHDPEDARRRHHA--------AAAAAVGSPKHHHHQQQ 1012
            |..|.||      |:|.            |...|.|.:..        .||..:|:        :
  Rat   967 SDSSLSS------PYPT------------DTLSALRGNSGTLLEGPGRTAADGIGT--------R 1005

  Fly  1013 QQPAPPPQQQQQQYQPQPPPQQVLPQPQPSIKYEPGQSQKKRILAMAQSECGYQPQ--------- 1068
            ....||.:.|............:|    .|.|.:|..|...:......:..||:.|
  Rat  1006 TIIVPPLKTQLGDCTGATQASGLL----SSSKTKPVASVSGQSSGCCITPTGYRAQRGGASAVQP 1066

  Fly  1069 ---VPSQPSSSASLPHIPTKQE----PAEFYPEYAAAPPQQLDTKRSSWAPTSSGSGVSALPLAH 1126
               ..:|.|||||     |.||    ||....:...||..|        ||.:...|.......|
  Rat  1067 LNLSQNQQSSSAS-----TSQERSSNPAPRRQQAFVAPLSQ--------APYAFQHGSPLHSTGH 1118

  Fly  1127 PKREAPSVAPISYVAPSVAPPLAHSKSSSASSSSSISAATAAAA------AAAAAAAASVGPPSW 1185
                 |.:||    ||:..|...|..:.:|.:|::...:|::.|      .::..|||....||.
  Rat  1119 -----PHLAP----APAHLPSQPHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPST 1174

  Fly  1186 GPPQVYRQPSQPPPGSVGLPGSTQPPPS-----SVAPHPHHHSHGHHHHQAGTP--LGGSPSST 1242
            ...||        |.|||        ||     ||||       ..:.||..|.  :|.|..||
  Rat  1175 LVHQV--------PVSVG--------PSLLTSASVAP-------AQYQHQFATQSYIGSSRGST 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	274/327 (84%)
		PHA03378	<1080..1327	CDD:223065	47/180 (26%)
Hipk1	XP_063138349.1	None