DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hipk and Clk2

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	XP_008759408.1	Gene:	Clk2 / 365842	RGDID:	1359711	Length:	540	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	120/388 - (30%)
Similarity:	193/388 - (49%)	Gaps:	66/388 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 HANTQPPSKRSSS-GADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKC--WKRGTSEIVAI 220
            |:::|..|:|:.| ..|.:..|:.| |...|...||::..||.||||:||:|  .:||.:. ||:
  Rat   170 HSSSQHSSRRAKSVEDDAEGHLIYH-VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGAR-VAL 232

  Fly   221 KILKNHPSYARQGQIEVSILSRLSQENADEFNF-VRAFECFQHKNHTCLVFEMLEQNLYDFLKQN 284
            ||:||...|....::|:::|.::::::.|..|. |:.|:.|.:..|.|:.||:|..:.:||||.|
  Rat   233 KIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDN 297

  Fly   285 KFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYR--------------- 334
            .:.|.|:..:|.:..|:..|:..|....|.|.|||||||:.|:   ..|.
  Rat   298 NYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVN---SDYELTYNLEKKRDERSVK 359

  Fly   335 ---VKVIDFGSAS----HVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWP 392
               |:|:|||||:    |.|     |.:.:|:|||||:||.|.:.:..|:||:||::.|.::|:.
  Rat   360 STAVRVVDFGSATFDHEHHS-----TIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFT 419

  Fly   393 LYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRD-VDSTYPFWRLKTTEEHEAETNTKSK 456
            |:......:.:..:.:..|.....|:....| .|:|||. :|     |...|:.......|  .|
  Rat   420 LFQTHDNREHLAMMERILGPVPSRMIRKTRK-QKYFYRGRLD-----WDENTSAGRYVREN--CK 476

  Fly   457 EARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSF 519
            ..|:|                     |.:|..|..:..||::.||..:..:|||..|||.|.|
  Rat   477 PLRRY---------------------LTSEAEDHHQLFDLIENMLEYEPAKRLTLGEALQHPF 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	110/354 (31%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Clk2	XP_008759408.1	PKc_CLK2	190..519	CDD:271117	114/368 (31%)
Clk2	XP_008759408.1	S_TKc	203..519	CDD:214567	110/354 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900