Protein Alignment Hipk and Hipk2

DIOPT Version :9

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_001102092.1
• Gene: Hipk2 / 362342
• RGDID: 1309349
• Length: 1195
• Species: Rattus norvegicus
• Alignment Length: 1264
• Identity: 489/1264 - (38%)
• Similarity: 629/1264 - (49%)
• Gaps: 348/1264 - (27%)

  Fly    70 HILRQPATSAS-TSSVAAAATSKRKRQTDCDCGCVDSY-------------NSS-------HGPP 113
            ||:...|:|.| |..|.....:..:|.|   ...:|:|             |:|       |.|.
  Rat    92 HIVVTSASSTSVTGQVLGGPHNLMRRST---VSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPM 153

  Fly   114 VQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQ 178
            :|.::|.|                       ::.||.|..||          ||.|.|.::||||
  Rat   154 IQNNASGA-----------------------TVATATTSTAT----------SKNSGSNSEGDYQ 185

  Fly   179 LVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRL 243
            |||||||.|::..|||||||||||||||||||||||:|||||||||||||||||||||||||:||
  Rat   186 LVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARL 250

  Fly   244 SQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKL 308
            |.|:||::|||||:|||||||||||||||||||||||||||||||||||||||:|:||.|||:||
  Rat   251 STESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKL 315

  Fly   309 KQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCE 373
            |.||||||||||||||||||.|||||||||||||||||||.||:|||||||||||||||||||||
  Rat   316 KSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCE 380

  Fly   374 AIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPF 438
            ||||||||||:||||||||||||:||:|||||||||||||.|::|::.:||::||.||.||.||.
  Rat   381 AIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL 445

  Fly   439 WRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTI 503
            |||||.::|||||..|||||||||||||||:.|||:.|||||..:|.||.||||||||||:||||
  Rat   446 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTI 510

  Fly   504 DQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRR--GDFHTVQPAST-LVTNFVPS 565
            |.::|:||.|.|||.|..:|||:|:.:..:||:..|.||:|:|  ..:.||..:.| .:|:..||
  Rat   511 DADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPS 575

  Fly   566 STENMTFTINNQLTSQVQRLVRDGRP----------------LAYEG-LYQIYNGRSVA----RQ 609
            ::.|:|.|.|||||:     |.:..|                |.|:. ||| .:..|:|    |.
  Rat   576 TSTNLTMTFNNQLTT-----VHNQAPTSTSATLSLANPEVSILNYQSTLYQ-PSAASMAAVAQRS 634

  Fly   610 YP-QT-------RTDSFQHQLVSNILCPPSYQTM-PSPTKHV-----------VVGSATMQPPLQ 654
            .| ||       |.|.||..|   |:|||.:|.: .||:||.           :|..|....|||
  Rat   635 MPLQTGTAQICARPDPFQQAL---IVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQ 696

  Fly   655 VPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQ-------QAPAHS 712
            :.|.                    ||..       |||...:|:.|.|:|.|       .:..|:
  Rat   697 IQPG--------------------LLAQ-------AWPGGAQQILLPPAWQQLTGVATHTSVQHA 734

  Fly   713 LIVDSTPLFNVEEI--------YPKH-------------HLNLPRNDLKKESPAHHIAKGNSYRV 756
            .::..| :...:::        :..|             |:.||.........||.:.:..:...
  Rat   735 AVIPET-MAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTT 798

  Fly   757 PRHEKKEHQQ----------------LSPVK-KRVKESSPPHQQRYQRAA--HVSPQYHAHHNCN 802
            ...:.|:||.                .||.: |||||::||      |.|  |.||.......|.
  Rat   799 SSRKSKQHQSSARNVSTCEVTSSQAISSPQRSKRVKENTPP------RCAMVHSSPACSTSLTCG 857

  Fly   803 YGNGSGYSASAGS----VVASSAASSSNIVNGSSSSSHHH---HVPVA---------------HA 845
            :|:|:..:.....    |:..:.:.:.:::..||.:....   |.|.:               |.
  Rat   858 WGDGASSTTRDRQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHD 922

  Fly   846 QPYSSSS------------GHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHV 898
            .|||.||            ||:..:..:..||
  Rat   923 SPYSDSSSNTSPYSVQQRTGHNGTNTLDTKGG--------------------------------- 954

  Fly   899 KQPTITIHDTPSPTAVITISDSEDEGGEAGGAQVPVLKQRA------------------HAQS-- 943
                :..|.|.:|..:|                ||.||.:|                  |:.|
  Rat   955 ----LENHCTGNPRTII----------------VPPLKTQASEVLVECDSLGPAISTGHHSSSFK 999

  Fly   944 --------QTSGSLLQHAPSSSCSRSSAHQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAA 1000
                    .|||    |: |.|.|.:.|::|..|.|..||||.:|.       ::.:.| .||..
  Rat  1000 SKSSSTVTSTSG----HS-SGSSSGAIAYRQQRPGPHFQQQQPLNL-------SQAQQH-MAADR 1051

  Fly  1001 VGSPKHHHHQQQQQPAPPPQQQQQQYQPQPPPQQVLPQPQ-PSIKYEPGQSQKKRILAMAQSECG 1064
            .||     |::||....|...|.....|...|......|. .:..:.|.|...
  Rat  1052 TGS-----HRRQQAYITPTMAQAPYTFPHSSPSHGTVHPHLAAAAHLPAQPHL------------ 1099

  Fly  1065 YQPQVPSQPSSSASLPHIPTKQEPAEFYPEYAAAPPQQLDTKRSSWAPTSSGSGVSALPLAHPKR 1129
            |....|:...|::::.|:...|..|....::.|.|...:..     .|.|.|..|...|..||.:
  Rat  1100 YTYTAPTALGSTSTVAHLVASQGSARHTVQHTAYPASIVHQ-----VPVSMGPRVLPSPTIHPSQ 1159

  Fly  1130 EAPSVAPISYVAPSVAP------PLAHSK 1152
            .....|..:|::.|.|.      ||:.:|
  Rat  1160 YPAQFAHQTYISASPASTVYTGYPLSPAK 1188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	274/327 (84%)
		PHA03378	<1080..1327	CDD:223065	19/79 (24%)
Hipk2	NP_001102092.1	STKc_HIPK2	183..537	CDD:271129	290/353 (82%)
		S_TKc	199..527	CDD:214567	274/327 (84%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	582	1.000	Domainoid score	I200
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	700	1.000	Inparanoid score	I640
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38932at33208
OrthoFinder	1	1.000	-	-		FOG0002956
OrthoInspector	1	1.000	-	-		otm44678
orthoMCL	1	0.900	-	-		OOG6_103159
Panther	1	1.100	-	-	LDO	PTHR24058
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X805
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830