Protein Alignment Hipk and Hipk2

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_001416116.1
• Gene: Hipk2 / 362342
• RGDID: 1309349
• Length: 1196
• Species: Rattus norvegicus
• Alignment Length: 1264
• Identity: 489/1264 - (38%)
• Similarity: 630/1264 - (49%)
• Gaps: 347/1264 - (27%)

  Fly    70 HILRQPATSAS-TSSVAAAATSKRKRQTDCDCGCVDSY-------------NSS-------HGPP 113
            ||:...|:|.| |..|.....:..:|.|   ...:|:|             |:|       |.|.
  Rat    92 HIVVTSASSTSVTGQVLGGPHNLMRRST---VSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPM 153

  Fly   114 VQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQ 178
            :|.::|.|                       ::.||.|..||          ||.|.|.::||||
  Rat   154 IQNNASGA-----------------------TVATATTSTAT----------SKNSGSNSEGDYQ 185

  Fly   179 LVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRL 243
            |||||||.|::..|||||||||||||||||||||||:|||||||||||||||||||||||||:||
  Rat   186 LVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARL 250

  Fly   244 SQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKL 308
            |.|:||::|||||:|||||||||||||||||||||||||||||||||||||||:|:||.|||:||
  Rat   251 STESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKL 315

  Fly   309 KQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCE 373
            |.||||||||||||||||||.|||||||||||||||||||.||:|||||||||||||||||||||
  Rat   316 KSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCE 380

  Fly   374 AIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPF 438
            ||||||||||:||||||||||||:||:|||||||||||||.|::|::.:||::||.||.||.||.
  Rat   381 AIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL 445

  Fly   439 WRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTI 503
            |||||.::|||||..|||||||||||||||:.|||:.|||||..:|.||.||||||||||:||||
  Rat   446 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTI 510

  Fly   504 DQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRR--GDFHTVQPAST-LVTNFVPS 565
            |.::|:||.|.|||.|..:|||:|:.:..:||:..|.||:|:|  ..:.||..:.| .:|:..||
  Rat   511 DADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPS 575

  Fly   566 STENMTFTINNQLTSQVQRLVRDGRP----------------LAYEG-LYQIYNGRSVA----RQ 609
            ::.|:|.|.|||||:     |.:..|                |.|:. ||| .:..|:|    |.
  Rat   576 TSTNLTMTFNNQLTT-----VHNQAPTSTSATLSLANPEVSILNYQSTLYQ-PSAASMAAVAQRS 634

  Fly   610 YP-QT-------RTDSFQHQLVSNILCPPSYQTM-PSPTKHV-----------VVGSATMQPPLQ 654
            .| ||       |.|.||..|   |:|||.:|.: .||:||.           :|..|....|||
  Rat   635 MPLQTGTAQICARPDPFQQAL---IVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQ 696

  Fly   655 VPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQ-------QAPAHS 712
            :.|.                    ||..:      |||...:|:.|.|:|.|       .:..|:
  Rat   697 IQPG--------------------LLAQQ------AWPGGAQQILLPPAWQQLTGVATHTSVQHA 735

  Fly   713 LIVDSTPLFNVEEI--------YPKH-------------HLNLPRNDLKKESPAHHIAKGNSYRV 756
            .::..| :...:::        :..|             |:.||.........||.:.:..:...
  Rat   736 AVIPET-MAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTT 799

  Fly   757 PRHEKKEHQQ----------------LSPVK-KRVKESSPPHQQRYQRAA--HVSPQYHAHHNCN 802
            ...:.|:||.                .||.: |||||::||      |.|  |.||.......|.
  Rat   800 SSRKSKQHQSSARNVSTCEVTSSQAISSPQRSKRVKENTPP------RCAMVHSSPACSTSLTCG 858

  Fly   803 YGNGSGYSASAGS----VVASSAASSSNIVNGSSSSSHHH---HVPVA---------------HA 845
            :|:|:..:.....    |:..:.:.:.:::..||.:....   |.|.:               |.
  Rat   859 WGDGASSTTRDRQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHD 923

  Fly   846 QPYSSSS------------GHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHV 898
            .|||.||            ||:..:..:..||
  Rat   924 SPYSDSSSNTSPYSVQQRTGHNGTNTLDTKGG--------------------------------- 955

  Fly   899 KQPTITIHDTPSPTAVITISDSEDEGGEAGGAQVPVLKQRA------------------HAQS-- 943
                :..|.|.:|..:|                ||.||.:|                  |:.|
  Rat   956 ----LENHCTGNPRTII----------------VPPLKTQASEVLVECDSLGPAISTGHHSSSFK 1000

  Fly   944 --------QTSGSLLQHAPSSSCSRSSAHQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAA 1000
                    .|||    |: |.|.|.:.|::|..|.|..||||.:|.       ::.:.| .||..
  Rat  1001 SKSSSTVTSTSG----HS-SGSSSGAIAYRQQRPGPHFQQQQPLNL-------SQAQQH-MAADR 1052

  Fly  1001 VGSPKHHHHQQQQQPAPPPQQQQQQYQPQPPPQQVLPQPQ-PSIKYEPGQSQKKRILAMAQSECG 1064
            .||     |::||....|...|.....|...|......|. .:..:.|.|...
  Rat  1053 TGS-----HRRQQAYITPTMAQAPYTFPHSSPSHGTVHPHLAAAAHLPAQPHL------------ 1100

  Fly  1065 YQPQVPSQPSSSASLPHIPTKQEPAEFYPEYAAAPPQQLDTKRSSWAPTSSGSGVSALPLAHPKR 1129
            |....|:...|::::.|:...|..|....::.|.|...:..     .|.|.|..|...|..||.:
  Rat  1101 YTYTAPTALGSTSTVAHLVASQGSARHTVQHTAYPASIVHQ-----VPVSMGPRVLPSPTIHPSQ 1160

  Fly  1130 EAPSVAPISYVAPSVAP------PLAHSK 1152
            .....|..:|::.|.|.      ||:.:|
  Rat  1161 YPAQFAHQTYISASPASTVYTGYPLSPAK 1189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	274/327 (84%)
		PHA03378	<1080..1327	CDD:223065	19/79 (24%)
Hipk2	NP_001416116.1	None