Protein Alignment Hipk and Dyrk2

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Alignment Length: 921
• Identity: 213/921 - (23%)
• Similarity: 350/921 - (38%)
• Gaps: 298/921 - (32%)

  Fly    43 DQTVTATT-------DGTRHQEQQQQQLQQQQQQHILRQPATSASTSSVAAAATSKRKRQTDCDC 100
            :.|||.|:       :|..:......          :..|.:|::|:|    :....:|
  Fly    85 ENTVTTTSLNGNGNGNGNSNSNNNNN----------IGSPVSSSTTNS----SNGGNER------ 129

  Fly   101 GCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGI-----GPISSLKTAHTKVATS---- 156
            |.....|||.|.....:|:::.|:|.:  |..:...|..:     ..::.|:....||...
  Fly   130 GSSTKSNSSSGSGSSGNSASSTGSGEL--KCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYF 192

  Fly   157 GGHANTQ-----PPSKRSSSGAD---GDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRG 213
            |.||:..     |.:..::.|.|   |:|::::|:   .::..||:||.:|:|:||||::.....
  Fly   193 GQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHD---HIAFRYEILEVIGKGSFGQVIRALDHK 254

  Fly   214 TSEIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNL 277
            |:..|||||::|...:..|..:|::||..|.:::|| ..|.:...:....:.|.|:.||::..||
  Fly   255 TNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNL 319

  Fly   278 YDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGS 342
            |:.:|:|.::...:..||.....::..|..|.:..:||.|||||||:|..  |....:|||||||
  Fly   320 YELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQ--RGSSSIKVIDFGS 382

  Fly   343 ASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYIS 407
            :.:|.:.: .||:|||:||:||:||||.:..|||||||||::|||:.|:||:||.:|.:|:..|.
  Fly   383 SCYVDRKI-YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIM 446

  Fly   408 QTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSK------EARKYIFNCL 466
            :..|||.:.:::.|.:...||    ||         .:.....||||.:      ::..:|.:|.
  Fly   447 EVLGLPPKVLISVARRRRLFF----DS---------RDAPRCITNTKGRKRSPGSKSLAHILHCQ 498

  Fly   467 DDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYC 531
            |                       |.|||.|:|.|..|...|:||.||.:|.|
  Fly   499 D-----------------------RYFIDFLQRCLEWDPAERMTPDEAAHHEF------------ 528

  Fly   532 NNVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEG 596
                                :||::                       |...|..|.....:..|
  Fly   529 --------------------LQPSA-----------------------SSRHRSCRMSSSSSSSG 550

  Fly   597 LYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMPSPTKHVVVGSATMQPPLQVPPQQYV 661
            |..:....|                      |....:..|.                       .
  Fly   551 LNSVSQKSS----------------------CYSFSEISPG-----------------------T 570

  Fly   662 NVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEI 726
            |.||..|:...|:         |..:.:|.....||..     |.|:..|:
  Fly   571 NGPVVASITSTTA---------VHNAAIATTTKSRQQP-----PSQSHGHA-------------- 607

  Fly   727 YPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPPHQQRYQRAAHV 791
              :.:.:||  |:|               :...:|....|...|:.::..|....:
  Fly   608 --QSNGHLP--DIK---------------LSASDKYNSMQKVAVRSKITSSVSDLE--------- 644

  Fly   792 SPQYHAHHNC--NYGNGSGYSASAGSVVASSAASSSNIVN------GSSSSSHHHHVPVAHAQPY 848
            |.|.::.|..  ..|:||.:..|:.:.......:.|.||.      |||:.:|:||
  Fly   645 SVQQYSLHRIYGGVGSGSTHHVSSAATRKHLPGTGSGIVGAMSSKYGSSTLAHNHH--------- 700

  Fly   849 SSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHVKQPTITIHDTPSPTA 913
              :..||..|....           ....|.|..||.|...|||                 |..:
  Fly   701 --NVTHHNASTATI-----------ATTTHHHHHHGGQQQQQSS-----------------SGAS 735

  Fly   914 VITISDSEDEG 924
            .:.:|.|:..|
  Fly   736 TMAMSHSQSTG 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	119/334 (36%)
		PHA03378	<1080..1327	CDD:223065
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	129/416 (31%)