DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hipk and dyrk1ab

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001334760.1	Gene:	dyrk1ab / 327466	ZFINID:	ZDB-GENE-030131-5677	Length:	719	Species:	Danio rerio

Alignment Length:	849	Identity:	223/849 - (26%)
Similarity:	330/849 - (38%)	Gaps:	210/849 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 HQEQQQQQLQQQQQQHILRQPATSASTSSVAAAATSKRKRQTDCDCGCVDSYNSSHGPPVQQDSS 119
            |..||.....||...    |..|....|....|.|:.::....|       :......|:::.|
Zfish     7 HSHQQYSDCHQQSTD----QSVTVLPYSDQTQALTASQRHMPQC-------FRDPTLAPLRKLS- 59

  Fly   120 AAAGAGSVGSKAGSGPGPDGIGPISSLKT---------AHTKVATSGGHANTQPPSKRSSSGADG 175
                                   |..:||         |..|.....|........|......||
Zfish    60 -----------------------IDLIKTYKHINEVYYAKKKRRHQQGQGEDSSHKKERKVFNDG 101

  Fly   176 ------DYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQ 234
                  ||.:...|   .....||:...:|:|:||||||.:.|...|.|||||:||..::..|.|
Zfish   102 YDDENYDYVVKNGE---KWMDRYEIDSLIGKGSFGQVVKAYDRAEQEWVAIKIIKNKKAFLNQAQ 163

  Fly   235 IEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPIL 298
            |||.:|..:::.:.: ::..|.....|..:||.|||||||..||||.|:...|..:.|...|...
Zfish   164 IEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFA 228

  Fly   299 EQVLTALLKL--KQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYR 361
            :|:.||||.|  .:|.:||.|||||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||:||
Zfish   229 QQLCTALLFLATPELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYR 290

  Fly   362 APEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSK 426
            :||::||:|:..|||||||||::.|:..|.||:.|::|.||:..|.:..|:|..|:::.|.|..|
Zfish   291 SPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPNHIMDLAPKARK 355

  Fly   427 FFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEK---- 487
            ||.:..|.|   |.:|.|::.:   ..|...:||     |..|  :.|.....||:...|.
Zfish   356 FFEKLSDGT---WSIKKTKDGK---RYKPPASRK-----LHAI--LGVECGGPGGRRAGESGHAV 407

  Fly   488 TDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGDFHTV 552
            .|..:|.||:.|||..|.:.|:.|..||.|||.:.|  .|  ...|..:||.......
Zfish   408 ADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT--TD--EGTNTSSSVSTSPALE------- 461

  Fly   553 QPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDS 617
            |..|:..|:...||:...:.|..:            ||..:....:..::........|....|:
Zfish   462 QSQSSGTTSSTSSSSGGSSGTSTS------------GRARSDPTHHHRHSSGHFGTAMPAIDCDN 514

  Fly   618 FQHQLVSNILCPPSYQTMPSPTKHVVVGSATMQPPLQVPPQQYVNVPVPVSMVEPTSGQRMLLTN 682
                     |||.:.|              ...||
Zfish   515 ---------LCPQARQ--------------PYHPP------------------------------ 526

  Fly   683 RVQASGVAWPQ-TGRQMALVPSWP-QQAPAHSLIVDSTPLFNVEEIYPKHHLNLPRNDLKKESPA 745
                  |.||. .|.:...|.:.| |:...|      .|..:.:.::|.||
Zfish   527 ------VVWPGIVGPEPVTVETHPVQETTFH------VPPQHPKALHPHHH-------------- 565

  Fly   746 HHIAKGNSYRVPRHEKKEHQQLSPVKKRVK-ESSPPHQQRYQRAAHVSPQYHAHHNCNYGNGSGY 809
            ||          .|....|.|:...:.|.: .:||.:....|.:..|   .|.|.:
Zfish   566 HH----------HHHHHHHGQVIATRPRPRLYNSPTNSASTQDSMEV---VHGHLS--------- 608

  Fly   810 SASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSS------SSGHHIVSNCNANGGAGG 868
            ..|..|..:||:.|||:..|..:.:....|:| |:...:|.      |.|....||.....|..|
Zfish   609 MTSLSSSASSSSTSSSSTGNHGNQAYQLRHLP-ANTLDFSQNGSLSMSMGLGAFSNPRQETGMAG 672

  Fly   869 AVVY 872
            ...|
Zfish   673 NPTY 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	133/334 (40%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
dyrk1ab	NP_001334760.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840