DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hipk and clk4a

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	XP_003199888.1	Gene:	clk4a / 321857	ZFINID:	ZDB-GENE-030131-576	Length:	496	Species:	Danio rerio

Alignment Length:	395	Identity:	125/395 - (31%)
Similarity:	194/395 - (49%)	Gaps:	73/395 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 HANTQPPS-------KRSSSGADGDYQLVQHEVLYS---LSAEYEVLEFLGRGTFGQVVKC---W 210
            |..:.|.|       |||.|..|.:   ..|.|.:|   |.|.||::..||.|.||:||:|   .
Zfish   132 HRRSHPHSDSRSHRRKRSRSVEDDE---EGHLVYHSGDMLRARYEIVCTLGEGAFGKVVECIDHE 193

  Fly   211 KRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLE 274
            |.|..  :|:||:||...|......||.:|.:::..:.| .:..||.::.|.|..|.|:.||:|.
Zfish   194 KVGAR--IALKIIKNIERYRDAALSEVEVLEQINSLDCDRRYACVRMYDWFDHHGHICIAFELLG 256

  Fly   275 QNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVD------------ 327
            .:.|||||:|.|.|..:.:||.:..|::.|:..|.:..|.|.|||||||:.|:
Zfish   257 LSTYDFLKENNFQPFYINHIRHMAYQIIRAVRFLHKNKLTHTDLKPENILFVNSEYNIRYNSKMK 321

  Fly   328 ----PVRQPYRVKVIDFGSAS--HVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAE 386
                .|:.| .|||:|||:|:  |...|   :.:.:|:|||||:||.|.:..:.|:||:||::.|
Zfish   322 RDERTVKNP-DVKVVDFGNATYEHEHHT---SVVSTRHYRAPEVILDLGWSHSCDVWSVGCILIE 382

  Fly   387 LFLGWPLYPGSSEFDQIRYISQTQG-LPTEHMLNSASKTSKFFYRD-VDSTYPFWRLKTTEEHEA 449
            .:||..|:......:.:..:.:..| :|| |||....| |:|...| :|     |.:.::...
Zfish   383 YYLGSTLFQTHDSKEHLAMMERVLGPIPT-HMLQKTRK-SRFVRNDKLD-----WDIHSSSGR-- 438

  Fly   450 ETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEA 514
            ....:.|..|:|                     |::..:|..:..||::|||..|..:|:|..||
Zfish   439 YVRKQCKPLRQY---------------------LVSSSSDHEQLFDLIERMLEYDVTKRITLDEA 482

  Fly   515 LNHSF 519
            :.|.|
Zfish   483 IKHPF 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	112/352 (32%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
clk4a	XP_003199888.1	PKc_like	159..488	CDD:304357	117/365 (32%)
clk4a	XP_003199888.1	S_TKc	172..488	CDD:214567	112/352 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810