DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hipk and Dyrk4

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	XP_038964750.1	Gene:	Dyrk4 / 312721	RGDID:	1306800	Length:	649	Species:	Rattus norvegicus

Alignment Length:	357	Identity:	134/357 - (37%)
Similarity:	193/357 - (54%)	Gaps:	41/357 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 SKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYA 230
            ||.|.....|.|..|.|:   .::..||||:.:|:|:||||.||.....:|:||:||::|...:.
  Rat   213 SKTSFDDEHGSYVKVLHD---HIAYRYEVLDMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFH 274

  Fly   231 RQGQIEVSILSRLSQENADE-FNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYI 294
            .|..:|:.||..|.:::.|. .|.|...:.|..:||.|:.||:|..|||:.:|.|.|....|..:
  Rat   275 HQALVELKILEALRRKDKDNTHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFQGFSLSIV 339

  Fly   295 RPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRY 359
            |.....||..|..|....:||.|||||||:|..  |....||||||||:.:..:.| .||:|||:
  Rat   340 RRFTLSVLKCLQMLYVEKIIHCDLKPENIVLYH--RGQVTVKVIDFGSSCYEHQKV-YTYIQSRF 401

  Fly   360 YRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKT 424
            ||:||:|||.|:..|||||||||::|||:.|:||:||.:|.:|:..|.:..|||..|::.:|::.
  Rat   402 YRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPTHLIQTATRR 466

  Fly   425 SKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPT--DLEGGQLLAEK 487
            ..||                         .||...|.|.|   :.|:...|.  ||.    :..|
  Rat   467 QIFF-------------------------DSKGLPKNITN---NRGEKRYPNSKDLP----MVVK 499

  Fly   488 TDRREFIDLLKRMLTIDQERRLTPAEALNHSF 519
            |....|:|.|:|.|..:...|:||.:||.|::
  Rat   500 TYDSSFLDFLRRCLVWEPSLRMTPDQALKHAW 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	127/331 (38%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Dyrk4	XP_038964750.1	PKc_DYRK4	192..532	CDD:271127	134/357 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910