DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and Dyrk1b

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	XP_006228683.1	Gene:	Dyrk1b / 308468	RGDID:	1307223	Length:	689	Species:	Rattus norvegicus

Alignment Length:	779	Identity:	215/779 - (27%)
Similarity:	305/779 - (39%)	Gaps:	236/779 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 HGPPVQQDSSAA-----AGAGSVGS---KAGSG----PG-------------PDGIGPISSL--K 147
            |..|..:..||:     :|.||.|:   ||..|    ||             |.|.||.|..  .
  Rat    12 HRAPAPRGPSASPDPGLSGGGSRGAGCEKAPPGRAPAPGLTPLRPSEPTMAVPPGHGPFSGFPGP 76

  Fly   148 TAHTKV-----------------ATSG-------------GHAN-----------TQPPSKRSSS 171
            ..||:|                 |||.             .|.|           .|.|.:.||:
  Rat    77 QEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSST 141

  Fly   172 ---------GADGDYQLVQHEVLYSLSAE-----YEVLEFLGRGTFGQVVKCWKRGTSEIVAIKI 222
                     |.|.|    .|:.:.. |.|     ||:...:|:|:||||||.:...|.|:|||||
  Rat   142 KKEKKVLNHGYDDD----NHDYIVR-SGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKI 201

  Fly   223 LKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKF 286
            :||..::..|.|||:.:|..::|.:.: ::..|.....|..:||.|||||:|..||||.|:...|
  Rat   202 IKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHF 266

  Fly   287 SPLPLKYIRPILEQVLTALLKL--KQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKT 349
            ..:.|...|.:.:|:.||||.|  .:|.:||.|||||||:|.:|.|.  .:|::||||:..:.:.
  Rat   267 RGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQR 329

  Fly   350 VCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPT 414
            :.. |:|||:||:||::||.|:..|||||||||::.|:..|.||:.||:|.||:..|.:..|:|.
  Rat   330 IYQ-YIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPP 393

  Fly   415 EHMLNSASKTSKFFYRDVDSTYP--FWRLKTTEE----HEAETNTKSKEARKYIFNCLDDIGQVN 473
            ..||..|.|..|:|.|     .|  .|.|:.|:|    ::.....:.:|.             :.
  Rat   394 APMLEQAPKARKYFER-----LPGGGWTLRRTKELRKDYQGPGTRRLQEV-------------LG 440

  Fly   474 VPTDLEGGQLLAE----KTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNV 534
            |.|...||:...|    ..|...|.||:.|||..:...|::|..||.|.|.|.|  .|
  Rat   441 VQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT--AD------- 496

  Fly   535 KASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQ 599
                   |....|...:....|....:..|||:...:.:.:...:....    |.|...|
  Rat   497 -------EATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSS----DNRAYRY----- 545

  Fly   600 IYNGRSVARQYPQTRTDSFQHQLVSNILC----PPSYQTMPSPTKHVVVGSATMQPPLQVPPQQ- 659
                                    ||..|    ||             :....|..| ||.|.|
  Rat   546 ------------------------SNRYCGGPGPP-------------ITDCEMNSP-QVLPSQP 572

  Fly   660 ---YVNVPVPVSMVE-PTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSL----IVD 716
               :....||....: ||||..:|      .:|...|...|.:...|| |...|...|    :|.
  Rat   573 LRPWAGGDVPHKTHQAPTSGSTLL------GTGAQLPPQPRCLGRPPS-PTSPPPPELMDVSLVG 630

  Fly   717 STPLFNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPP 780
            |.|     :..|.|....|                           :|...|.::.|:....||
  Rat   631 SPP-----DCSPPHPAPAP---------------------------QHPAASALRTRMTGGRPP 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	129/340 (38%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Dyrk1b	XP_006228683.1	PKc_DYRK1	157..496	CDD:271128	135/362 (37%)
Dyrk1b	XP_006228683.1	S_TKc	171..491	CDD:214567	129/340 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810