DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and Clk1

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001100383.2	Gene:	Clk1 / 301434	RGDID:	1311469	Length:	483	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	134/458 - (29%)
Similarity:	215/458 - (46%)	Gaps:	96/458 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 VDSYNSSH------------GPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTA-----H 150
            ||.|.:.:            |...|..||.::|      ::|.          ||.|:.     |
  Rat    73 VDEYRNDYMTYEPGYPYGEPGSRYQNHSSKSSG------RSGR----------SSYKSKHRSHHH 121

  Fly   151 TKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYS---LSAEYEVLEFLGRGTFGQVVKC--W 210
            |....|.|.::.:   |||.|..|.:   ..|.:..|   |||.||:::.||.|.||:||:|  .
  Rat   122 TSHRRSHGKSHRR---KRSRSVEDDE---EGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDH 180

  Fly   211 KRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADE----FNFVRAFECFQHKNHTCLVFE 271
            |.| ...||:||:||...|....|.|:.:|..|   ||.:    |..|:..|.|:|:.|.|:|||
  Rat   181 KVG-GRHVAVKIVKNVDRYCEAAQSEIQVLEHL---NATDPHSTFRCVQMLEWFEHRGHICIVFE 241

  Fly   272 MLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLV-DPVRQPYR- 334
            :|..:.|||:|:|.|.|..:.:||.:..|:..::..|....|.|.|||||||:.| ....:.|.
  Rat   242 LLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNP 306

  Fly   335 -------------VKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAE 386
                         :||:|||||::..:. .:|.:.:|:|||||:||.|.:.:..|:||:||::.|
  Rat   307 KMKRDERTIVNPDIKVVDFGSATYDDEH-HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIE 370

  Fly   387 LFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAET 451
            .:||:.::|.....:.:..:.:..|...:||:....|.:.|.:..:|     |     :||.:
  Rat   371 YYLGFTVFPTHDSREHLAMMERILGPLPKHMIEKTRKRTYFHHDRLD-----W-----DEHSS-- 423

  Fly   452 NTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALN 516
                  |.:|:......:.:.          :|::..:.....||:.:||..|..:|:|..|||.
  Rat   424 ------AGRYVSRRCKPLKEF----------MLSQDAEHELLFDLIGKMLEYDPAKRITLKEALK 472

  Fly   517 HSF 519
            |.|
  Rat   473 HPF 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	108/349 (31%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Clk1	NP_001100383.2	PKc_CLK1_4	147..476	CDD:271115	113/362 (31%)
Clk1	NP_001100383.2	S_TKc	160..476	CDD:214567	108/349 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810