DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and Prpf4b

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001011923.1	Gene:	Prpf4b / 291078	RGDID:	1307784	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	147/532 - (27%)
Similarity:	238/532 - (44%)	Gaps:	70/532 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FCSGLGAGLSVRATSFYGDQTVTATTDGTRHQEQQQQQLQQQ--QQQHILRQPATSASTSSVAAA 87
            |...|..|:.|...|...|.    ..|....:|.::..::|:  |:|.|:::....|..|:::..
  Rat   504 FKGSLSEGMKVEQESSSDDN----LEDFDVEEEDEEAVIEQRRIQRQAIVQKYKYLAEDSNISVP 564

  Fly    88 A------TSKRKRQTDCD------CGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGP----G 136
            :      :|.|.|....|      ...|..|...:....:....|.....:|....||..    .
  Rat   565 SEPSSPQSSTRSRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLA 629

  Fly   137 PDGIGPISSL-----KTAHTKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLE 196
            ||.......:     .:|..:.|..|......|..:.:.:.|:|.|::...||   |...|.|..
  Rat   630 PDMFTESDDMFAAYFDSARLRAAGIGKDFKENPNLRDNWTDAEGYYRVNIGEV---LDKRYNVYG 691

  Fly   197 FLGRGTFGQVVKCWKRG-TSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADE-FNFVRAFEC 259
            :.|:|.|..||:..... .::.||:||::|:....:.|..|:..|.:|:..:.|: |:.:|.|..
  Rat   692 YTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRH 756

  Fly   260 FQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENI 323
            |.||.|.|||||.|..||.:.||: .|...|.:|.:|...:|:..||..||:..::|||:||:||
  Rat   757 FYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNI 821

  Fly   324 MLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELF 388
            ::.:   ....:|:.||||||||:......||.||:|||||||:|..:...|||||:||.:.||:
  Rat   822 LVNE---SKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELY 883

  Fly   389 LGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSA-------SKTSKFFYRDVDSTYPFWRLKTTEE 446
            .|..|:||.:....::.....:|.....|:...       .:...|.|.:||        |.||.
  Rat   884 TGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVD--------KVTER 940

  Fly   447 HEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFI----DLLKRMLTIDQER 507
            .:....:.....:..:             .||.|.|.|.|  |:|:.:    |||.::|.:|..:
  Rat   941 EKVTVMSTINPTKDLL-------------ADLIGCQRLPE--DQRKKVHQLKDLLDQILMLDPAK 990

  Fly   508 RLTPAEALNHSF 519
            |::..:||.|:|
  Rat   991 RISINQALQHAF 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	111/342 (32%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Prpf4b	NP_001011923.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..535		8/34 (24%)
		PTZ00108	<171..396	CDD:240271
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..583		3/22 (14%)
		STKc_PRP4	686..1003	CDD:271037	111/343 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810