Protein Alignment Hipk and HIPK2

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: XP_011514379.1
• Gene: HIPK2 / 28996
• HGNCID: 14402
• Length: 1377
• Species: Homo sapiens
• Alignment Length: 1462
• Identity: 515/1462 - (35%)
• Similarity: 672/1462 - (45%)
• Gaps: 455/1462 - (31%)

  Fly    23 SGFCS---------------GLGAGLSVRATSFYGDQTVTATTDGTRHQEQQQQQLQQQQ----- 67
            |.|||               |.|:...|.:.|.....:..|||..:.........|..:|
Human   202 SAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFP 266

  Fly    68 --QQHILRQPATSAS-TSSVAAAATSKRKRQTDCDCGCVDSY-------------NSS------- 109
              ..||:...|:|.| |..|.....:..:|.|   ...:|:|             |:|
Human   267 GSTGHIVVTSASSTSVTGQVLGGPHNLMRRST---VSLLDTYQKCGLKRKSEEIENTSSVQIIEE 328

  Fly   110 HGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGAD 174
            |.|.:|.::|.|                       ::.||.|..||          ||.|.|.::
Human   329 HPPMIQNNASGA-----------------------TVATATTSTAT----------SKNSGSNSE 360

  Fly   175 GDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSI 239
            |||||||||||.|::..|||||||||||||||||||||||:||||||||||||||||||||||||
Human   361 GDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSI 425

  Fly   240 LSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTA 304
            |:|||.|:||::|||||:|||||||||||||||||||||||||||||||||||||||:|:||.||
Human   426 LARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATA 490

  Fly   305 LLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGL 369
            |:|||.||||||||||||||||||.|||||||||||||||||||.||:|||||||||||||||||
Human   491 LMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGL 555

  Fly   370 PFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDS 434
            ||||||||||||||:||||||||||||:||:|||||||||||||.|::|::.:||::||.||.||
Human   556 PFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDS 620

  Fly   435 TYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKR 499
            .||.|||||.::|||||..|||||||||||||||:.|||:.|||||..:|.||.||||||||||:
Human   621 PYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKK 685

  Fly   500 MLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRR--GDFHTVQPAST-LVTN 561
            |||||.::|:||.|.|||.|..:|||:|:.:..:||:..|.||:|:|  ..:.||..:.| .:|:
Human   686 MLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITH 750

  Fly   562 FVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQT------------- 613
            ..||::.|:|.|.|||||:     |.:..|.:......:.|.......||.|
Human   751 VAPSTSTNLTMTFNNQLTT-----VHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVA 810

  Fly   614 ---------------RTDSFQHQLVSNILCPPSYQTM-PSPTKHV-----------VVGSATMQP 651
                           |.|.||..|   |:|||.:|.: .||:||.           :|..|....
Human   811 QRSMPLQTGTAQICARPDPFQQAL---IVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQ 872

  Fly   652 PLQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQ-------QAP 709
            |||:.|.                    ||..:      |||...:|:.|.|:|.|       .:.
Human   873 PLQIQPG--------------------LLAQQ------AWPSGTQQILLPPAWQQLTGVATHTSV 911

  Fly   710 AHSLIVDSTPLFNVEEI--------YPKH-------------HLNLPRNDLKKESPAHHIAKGNS 753
            .|:.::..| :...:::        :..|             |:.||.........||.:.:..:
Human   912 QHATVIPET-MAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPT 975

  Fly   754 YRVPRHEKKEHQQ----------------LSPVK-KRVKESSPPHQQRYQRAA--HVSPQYHAHH 799
            ......:.|:||.                .||.: |||||::||      |.|  |.||......
Human   976 STTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP------RCAMVHSSPACSTSV 1034

  Fly   800 NCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANG 864
            .|.:|:           ||||..
Human  1035 TCGWGD-----------VASSTT------------------------------------------ 1046

  Fly   865 GAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHVKQPTITIHDTPSPT-AVITISDSEDEGGEAG 928
                                           :..::.||.|.|||||| :|||||...||..|.
Human  1047 -------------------------------RERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ- 1079

  Fly   929 GAQVPVLKQRAHAQSQTSGSLLQHAPSSSCSRS--------SAHQQPH--------PHPQQQQQQ 977
                                  :|||:|:.|:.        :.|..|:        |:..||:..
Human  1080 ----------------------KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAG 1122

  Fly   978 QINYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQQQQQQYQPQPPPQQVLPQPQ-- 1040
            ..|....|.:.:...|      ..|:|:        ....||.:.|        ..:||.:..
Human  1123 HNNANAFDTKGSLENH------CTGNPR--------TIIVPPLKTQ--------ASEVLVECDSL 1165

  Fly  1041 -PSIKYEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASLPHIPTKQEPAEFYPEYAAAPPQQLD 1104
             |........|.|.:..:...|..|:     |..|||.::.:  .:|.|.   |.:....|..|.
Human  1166 VPVNTSHHSSSYKSKSSSNVTSTSGH-----SSGSSSGAITY--RQQRPG---PHFQQQQPLNLS 1220

  Fly  1105 TKRSSWAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSVAPPLAHSKSSSASSSSSISAATAAA 1169
            ..:.......:||        |.:::|       |:.|::| ...:|...::.|..::....|||
Human  1221 QAQQHITTDRTGS--------HRRQQA-------YITPTMA-QAPYSFPHNSPSHGTVHPHLAAA 1269

  Fly  1170 AAAAAAAAASVGPPSWGPPQVYRQPSQP------PPGSVGLPGSTQPPPSSVAPHPHHHSHGHHH 1228
            ||||                  ..|:||      .|.::|..|:.....:|.....|...|..:.
Human  1270 AAAA------------------HLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYP 1316

  Fly  1229 ----HQAGTPLGGSPSSTAAAALLQPDIYAQGDIYRRPTVFVSQAAPSYAYANRAVVAPPPAHNS 1289
                ||.       |.|.....|..|.|:        |:.:.:|      :|::..::..||
Human  1317 ASIVHQV-------PVSMGPRVLPSPTIH--------PSQYPAQ------FAHQTYISASPA--- 1357

  Fly  1290 SSRQVIPSHPLPAHIQIPTQYSQFGPLSPAQV 1321
                             .|.|:.: |||||:|
Human  1358 -----------------STVYTGY-PLSPAKV 1371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	274/327 (84%)
		PHA03378	<1080..1327	CDD:223065	50/252 (20%)
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	290/353 (82%)