DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and Clk4

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	XP_038941309.1	Gene:	Clk4 / 287269	RGDID:	1310274	Length:	507	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	128/464 - (27%)
Similarity:	206/464 - (44%)	Gaps:	115/464 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 STSSVAAAATS-KRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPI 143
            |.|||.:..:| ||||...|         :||
  Rat   128 SKSSVRSRRSSPKRKRNRHC---------ASH--------------------------------- 150

  Fly   144 SSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYS---LSAEYEVLEFLGRGTFGQ 205
                .:|:|     .|..     |||.|..|.:   ..|.:..|   |.|.||:::.||.|.||:
  Rat   151 ----QSHSK-----SHRR-----KRSRSIEDDE---EGHLICQSGDVLRARYEIVDTLGEGAFGK 198

  Fly   206 VVKCWKRGTSEI-VAIKILKNHPSYARQGQIEVSILSRLSQENADE-FNFVRAFECFQHKNHTCL 268
            ||:|...|...: ||:||:||...|....:.|:.:|..|:..:.:. |..|:..|.|.|..|.|:
  Rat   199 VVECIDHGMDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCI 263

  Fly   269 VFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLV------- 326
            |||:|..:.|||:|:|.|.|..:.:||.:..|:..::..|....|.|.|||||||:.|
  Rat   264 VFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVK 328

  Fly   327 --DPVRQPYR------VKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCV 383
              ..:::..|      :||:|||||::..:. .:|.:.:|:|||||:||.|.:.:..|:||:||:
  Rat   329 YNSKMKRDERTLKNTDIKVVDFGSATYDDEH-HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCI 392

  Fly   384 VAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHE 448
            :.|.:||:.::......:.:..:.:..|....||:....|...|.:..:|     |     :||.
  Rat   393 LIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTRKRKYFHHNQLD-----W-----DEHS 447

  Fly   449 AE---TNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLT 510
            :.   ...:.|..::::. |.|:                    :..:..||::|||..|..:|:|
  Rat   448 SAGRYVRRRCKPLKEFML-CHDE--------------------EHEKLFDLVRRMLEYDPTKRIT 491

  Fly   511 PAEALNHSF 519
            ..|||.|.|
  Rat   492 LDEALQHPF 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	104/348 (30%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Clk4	XP_038941309.1	PKc_CLK1_4	172..501	CDD:271115	108/361 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900