DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hipk and pom2

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_593081.2	Gene:	pom2 / 2542326	PomBaseID:	SPAC16C9.07	Length:	836	Species:	Schizosaccharomyces pombe

Alignment Length:	348	Identity:	128/348 - (36%)
Similarity:	200/348 - (57%)	Gaps:	39/348 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 DGDYQLVQHE-VLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEV 237
            :|||:.:|.: :||    .||:::.:|:|:||||:||......::||||::||...:..|..:||
pombe   503 NGDYKAIQGDHLLY----RYEIIDTVGKGSFGQVLKCIDHKRGQVVAIKVIKNRQKFHGQTLVEV 563

  Fly   238 SILSRLSQ-ENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQV 301
            .||.||.: :.||:.|.:|....|..:.|.|:|.|:|..||:|.:::|.:..|||..::....|.
pombe   564 GILKRLCEADPADKNNVIRYLSHFDFRGHLCIVTELLGSNLFDVIRENNYKGLPLIVVKSFALQG 628

  Fly   302 LTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEII 366
            |.||..|:...:||.||||||::|..|::.  |:|:|||||:...::.| .||||||:|||||||
pombe   629 LQALRLLQGQNIIHCDLKPENLLLSHPLKA--RIKLIDFGSSCFYNEKV-YTYLQSRFYRAPEII 690

  Fly   367 LGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRD 431
            |||.:.:.||:||.||::||||.|.||:||.:|.:|:.||.:..|.|...::.:::: ||.::..
pombe   691 LGLEYGKEIDIWSFGCILAELFTGVPLFPGGNETEQLGYIMEVLGPPPMALIRNSTR-SKAYFDS 754

  Fly   432 VDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDL 496
            ....:|.     |:.|                      .::.||:.....|||  .|.:..|:|.
pombe   755 EGKPHPI-----TDSH----------------------NRLLVPSTRTFSQLL--NTKQASFLDF 790

  Fly   497 LKRMLTIDQERRLTPAEALNHSF 519
            |.:.|..|.:.|:|...||.|.|
pombe   791 LSKCLKWDPKDRITVDSALQHEF 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	122/329 (37%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
pom2	NP_593081.2	PKc_DYRK	504..814	CDD:271112	128/347 (37%)
pom2	NP_593081.2	S_TKc	518..814	CDD:214567	122/329 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840