DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hipk and Dyrk1a

DIOPT Version :9

Sequence 1:NP_001369036.1 Gene:Hipk / 38070 FlyBaseID:FBgn0035142 Length:1409 Species:Drosophila melanogaster
Sequence 2:NP_036923.1 Gene:Dyrk1a / 25255 RGDID:2528 Length:763 Species:Rattus norvegicus


Alignment Length:923 Identity:253/923 - (27%)
Similarity:362/923 - (39%) Gaps:263/923 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 DQTVTATTDGTRHQEQQQQQLQQQQQQHIL----------RQPATSASTS-SVAAAAT------- 89
            ||.|:|.:    :.:|.||.|..|....|:          |.|||:.... ||....|       
  Rat    50 DQQVSALS----YSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEV 110

  Fly    90 --SKRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTK 152
              :|:||:              |    ||                 |.|.|         ::|.|
  Rat   111 YYAKKKRR--------------H----QQ-----------------GQGDD---------SSHKK 131

  Fly   153 VATSGGHANTQPPSKRSSSGADG---DYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGT 214
                        ..|..:.|.|.   ||.:...|   .....||:...:|:|:||||||.:.|..
  Rat   132 ------------ERKVYNDGYDDDNYDYIVKNGE---KWMDRYEIDSLIGKGSFGQVVKAYDRVE 181

  Fly   215 SEIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLY 278
            .|.|||||:||..::..|.||||.:|..:::.:.: ::..|.....|..:||.|||||||..|||
  Rat   182 QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLY 246

  Fly   279 DFLKQNKFSPLPLKYIRPILEQVLTALLKL--KQLGLIHADLKPENIMLVDPVRQPYRVKVIDFG 341
            |.|:...|..:.|...|...:|:.||||.|  .:|.:||.|||||||:|.:|.|.  .:|::|||
  Rat   247 DLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRS--AIKIVDFG 309

  Fly   342 SASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYI 406
            |:..:.:.:.. |:|||:||:||::||:|:..|||||||||::.|:..|.||:.|::|.||:..|
  Rat   310 SSCQLGQRIYQ-YIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI 373

  Fly   407 SQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQ 471
            .:..|:|..|:|:.|.|..|||.:..|.|   |.||.|::.:.|  .|....|| :.|.|     
  Rat   374 VEVLGIPPAHILDQAPKARKFFEKLPDGT---WSLKKTKDGKRE--YKPPGTRK-LHNIL----- 427

  Fly   472 VNVPTDLEGGQLLAEK----TDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCN 532
             .|.|...||:...|.    .|..:|.||:.|||..|.:.|:.|..||.|||.:.|........|
  Rat   428 -GVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSN 491

  Fly   533 NVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGL 597
            :|..|..|           .|..|:..|:...||:...:.|.|                      
  Rat   492 SVSTSPAM-----------EQSQSSGTTSSTSSSSGGSSGTSN---------------------- 523

  Fly   598 YQIYNGRSVARQYPQTRTDSFQHQ------LVSNILC----PPSYQTMPSPTKHVVVGSATMQPP 652
                :||  ||..|   |...:|.      .|..:.|    |...|..|:|     :|.:..:.|
  Rat   524 ----SGR--ARSDP---THQHRHSGGHFAAAVQAMDCETHSPQVRQQFPAP-----LGWSGTEAP 574

  Fly   653 LQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDS 717
            .||..:                      |:.||       :|...:|     |||...|      
  Rat   575 TQVTVE----------------------THPVQ-------ETTFHVA-----PQQNALH------ 599

  Fly   718 TPLFNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKE---SSP 779
                       .||.|        .|..||         ..|....|.....:..|.:.   :||
  Rat   600 -----------HHHGN--------SSHHHH---------HHHHHHHHHGQQALGNRTRPRVYNSP 636

  Fly   780 PHQQRYQRAAHVSPQYHAHHNCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVA- 843
            .:....|.:..|.   |:||:         ..|..|...||:.|||:  .|:..:..:.:.||| 
  Rat   637 TNSSSTQDSMEVG---HSHHS---------MTSLSSSTTSSSTSSSS--TGNQGNQAYQNRPVAA 687

  Fly   844 ----HAQPYSSSSGHHIVSNCNANGGAGGAVVYQ----QPPAHAHQQHGQQPHPQSSQHPQHVKQ 900
                ..|..:......:.||.....|..|...||    ..|||    :..:.|....|.....:.
  Rat   688 NTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAH----YMTEGHLTMRQGADREES 748

  Fly   901 PTITIHDTPSPTA 913
            |...:....||.|
  Rat   749 PMTGVCVQQSPVA 761

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HipkNP_001369036.1 STKc_HIPK 192..520 CDD:271113 137/334 (41%)
PHA03378 <1080..1327 CDD:223065
Dyrk1aNP_036923.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 33..56 3/5 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 115..136 11/76 (14%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 117..134 9/72 (13%)
PKc_DYRK1 148..484 CDD:271128 140/353 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..442 11/42 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..540 18/96 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..679 25/130 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..763 4/18 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0667
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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