Protein Alignment Hipk and Dyrk3

DIOPT Version :9

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_663483.1
• Gene: Dyrk3 / 226419
• MGIID: 1330300
• Length: 586
• Species: Mus musculus
• Alignment Length: 554
• Identity: 165/554 - (29%)
• Similarity: 246/554 - (44%)
• Gaps: 97/554 - (17%)

  Fly    14 DYAVAGGGGSGFCSGLGAGLSVRATSFYGDQTVTATTDGTRHQE--QQQQQLQQQQQQHILRQPA 76
            |.|:.|.|.......||.|:       |....:...|.|..:.:  ....:....::.:|..:|.
Mouse    12 DAALPGAGLPPQQRRLGDGV-------YDTFMMIDETKGPPYSDTFSNPSEAPVSRRLNITTEPL 69

  Fly    77 TSASTSSVAAAATSK----------RKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKA 131
            |...|......:..|          |:..|....|..:|..||  |..|..||.:..|    .|.
Mouse    70 TRGHTQHFVNGSEMKVEQLFQEFGNRRSNTLQSDGISNSEKSS--PASQGKSSESLSA----VKC 128

  Fly   132 GSGPGPDGIGPIS---SLK------TAHTKV-------------------ATSGGHANTQPPSKR 168
            .....|..:.|::   :||      ||:.|:                   ...||      |:..
Mouse   129 NLSSRPSKVLPLTPEQALKQYKHHLTAYEKLEIVSYPEIYFVGPNAKKRQGVIGG------PNNG 187

  Fly   169 SSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQG 233
            ....|||.|..|..:   .|:..||||:.:|:|:||||.:.:.....:.||:|:::|...:.||.
Mouse   188 GYDDADGAYIHVPRD---HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQA 249

  Fly   234 QIEVSILSRL-SQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPI 297
            ..|:.||..| .|:.....|.:...|.|..:||.|:.||:|..:||:.:|:|||....::.:|..
Mouse   250 AEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKF 314

  Fly   298 LEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRA 362
            .:.:|.:|..|.:..:||.|||||||:|....|.  ..|||||||:....:.: .||:|||:|||
Mouse   315 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRS--ATKVIDFGSSCFEYQKL-YTYIQSRFYRA 376

  Fly   363 PEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKF 427
            ||||||..:...||:||.||::|||..|.||:||..|.||:..:.:..|:|.:.:|.. ||.:|:
Mouse   377 PEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQ-SKRAKY 440

  Fly   428 F--------YRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEG-GQL 483
            |        |..|.:        .|:........:|:..:|     ....|..:..|.|:| |..
Mouse   441 FINSKGLPRYCSVST--------QTDGRVVLLGGRSRRGKK-----RGPPGSKDWATALKGCGDY 492

  Fly   484 LAEKTDRREFIDLLKRMLTIDQERRLTPAEALNH 517
            |        ||:.|||.|..|...|||||:||.|
Mouse   493 L--------FIEFLKRCLQWDPSARLTPAQALRH 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	122/336 (36%)
		PHA03378	<1080..1327	CDD:223065
Dyrk3	NP_663483.1	Disordered. /evidence=ECO:0000250|UniProtKB:O43781	1..187		37/193 (19%)
		PKc_DYRK2_3	142..521	CDD:271126	136/411 (33%)
		S_TKc	208..521	CDD:214567	122/336 (36%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O43781	467..480		3/17 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840