DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and HIPK1

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001356735.1	Gene:	HIPK1 / 204851	HGNCID:	19006	Length:	1210	Species:	Homo sapiens

Alignment Length:	1408	Identity:	518/1408 - (36%)
Similarity:	645/1408 - (45%)	Gaps:	396/1408 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PPKASDFVDYAVAGGGGSGFCSGL-----GAGLSVRATS----FYGDQTVTATTDGTRHQEQQ-- 59
            ||..|           .|.|||..     .:|..|...|    :|........|.|..:...|
Human    10 PPSVS-----------SSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVA 63

  Fly    60 QQQLQQQQQQHILRQPA-----TSASTSSVAAAATSKRKRQTDC------------DCGC----- 102
            ...:....|..:|..||     .:|:.||.:||.::.:..||..            .||.
Human    64 NFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSE 128

  Fly   103 -VDSYNS----SHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANT 162
             |||..|    ...||:...:....||.:                                 ..|
Human   129 EVDSNGSVQIIEEHPPLMLQNRTVVGAAA---------------------------------TTT 160

  Fly   163 QPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHP 227
            ...:|.|||..:|||||||||:|.|::..|||||||||||||||.|||||.|.||||||||||||
Human   161 TVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHP 225

  Fly   228 SYARQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 292
            |||||||||||||||||.|||||:||||::|||||||||||||||||||||||||||||||||||
Human   226 SYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 290

  Fly   293 YIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQS 357
            ||||||:||.|||:|||.||||||||||||||||||||||||||||||||||||||.||:|||||
Human   291 YIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQS 355

  Fly   358 RYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSAS 422
            ||||||||||||||||||||||||||:||||||||||||:||:|||||||||||||.|::|::.:
Human   356 RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGT 420

  Fly   423 KTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEK 487
            ||::||.||.:..||.|||||.||||.||..|||||||||||||||:.|||:.|||||..:||||
Human   421 KTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEK 485

  Fly   488 TDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRR--GDFH 550
            .||||:|||||:|||||.::|:||.:.|||.|..:|||:|:.:.|:||:..|.||:|:|  ..:.
Human   486 ADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYD 550

  Fly   551 TV-QPASTLVTNFVPSSTENMTFTINNQL-TSQVQRLVRDGRPLAYEGLYQIYNG-----RSVAR 608
            || |..|...|:..|:::.|:|.:.:||| |...|..|......|......:.|.     ...:.
Human   551 TVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSA 615

  Fly   609 QYPQ-----------------------TRTDSFQHQLVSNILCPPSYQT-MPSPTKH-------- 641
            .||.                       |:||.||...   |:|||::|| :.:.|||
Human   616 LYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTF---IVCPPAFQTGLQATTKHSGFPVRMD 677

  Fly   642 ---VVVGSATMQPPLQVP------------------PQ------QYVNVPVPVSMVEPTSGQRML 679
               .:|..|....|||:.                  ||      ||. ||..:|    .:..|..
Human   678 NAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYA-VPFTLS----CAAGRPA 737

  Fly   680 LTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIYPKHHLNLPRNDLKKESP 744
            |..:..|...||| .|.|..|:||..||.|..:|.....|...:.|
Human   738 LVEQTAAVLQAWP-GGTQQILLPSTWQQLPGVALHNSVQPTAMIPE------------------- 782

  Fly   745 AHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPPHQQRYQRAAHVSPQYHAHHNCNYGNGSGY 809
                |.|:.           |||:..:..                      |:|       |:.|
Human   783 ----AMGSG-----------QQLADWRNA----------------------HSH-------GNQY 803

  Fly   810 SASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQ 874
            |        :.....|.:.|         ||.:|.|||.:....|               ||.||
Human   804 S--------TIMQQPSLLTN---------HVTLATAQPLNVGVAH---------------VVRQQ 836

  Fly   875 PPAHAHQQHGQQPHPQSSQ-------------------------------HPQHVKQPTITIHDT 908
            ..:....:..:|..|.||:                               ..||  || |.|.||
Human   837 QSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQH--QP-IIIPDT 898

  Fly   909 PS-PTAVITI-SDSEDEGGEAGGAQVPVLKQRAHAQSQTSGSLLQHAPSSSCSRSSAHQQPHPHP 971
            || |.:|||| ||:::|...........||.|::..|..:   :..:|.|..|.||.:..
Human   899 PSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVT---VNDSPDSDSSLSSPYST----- 955

  Fly   972 QQQQQQQINYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQQQQQQYQPQPPPQQVL 1036
                         |...|.|.:..:.....|.........:....||.:.|............:|
Human   956 -------------DTLSALRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLL 1007

  Fly  1037 PQPQPSIKYEPGQSQKKRILAMAQSEC-----GYQPQVPSQPSSSASLPHIPTKQEPAEFYPEYA 1096
            ......:....|||          |.|     ||:.|   :..:|                   |
Human  1008 SNKTKPVASVSGQS----------SGCCITPTGYRAQ---RGGTS-------------------A 1040

  Fly  1097 AAPPQQLDTKRSSWAPTSSGSGVSALPLAHPKREAPSVAPISYVA--------------PSVAPP 1147
            |.|......::||.||||...  |:.|.  |:|:...|||:|...              |.:||.
Human  1041 AQPLNLSQNQQSSAAPTSQER--SSNPA--PRRQQAFVAPLSQAPYTFQHGSPLHSTGHPHLAPA 1101

  Fly  1148 LAHSKSSSASSSSSISAATAAAAAAAAAAAASVGPPSWGPPQVYRQPSQPP------PGSVGLPG 1206
            .||..|.  :...:.:|.|:|||..:.::.|.:..|...........:.|.      |.|||
Human  1102 PAHLPSQ--AHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVG--- 1161

  Fly  1207 STQPPPS-----SVAPHPHHHSHGHHHHQAGTP--LGGSPSST 1242
                 ||     ||||       ..:.||..|.  :|.|..||
Human  1162 -----PSLLTSASVAP-------AQYQHQFATQSYIGSSRGST 1192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	274/327 (84%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065	48/190 (25%)
HIPK1	NP_001356735.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1084..1103		3/18 (17%)
		STKc_HIPK1	174..528	CDD:271130	289/353 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..856		6/20 (30%)
		Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250	844..847		0/2 (0%)
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:12702766	885..1093		61/267 (23%)
		Required for localization to nuclear speckles. /evidence=ECO:0000250	891..998		32/128 (25%)
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	902..926		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..974		15/85 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1069		9/26 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	581	1.000	Domainoid score	I211
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	696	1.000	Inparanoid score	I683
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38932at33208
OrthoFinder	1	1.000	-	-		FOG0002956
OrthoInspector	1	1.000	-	-		otm40540
orthoMCL	1	0.900	-	-		OOG6_103159
Panther	1	1.100	-	-	O	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X805
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.900