DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hipk and Y111B2A.1

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_499631.2	Gene:	Y111B2A.1 / 190948	WormBaseID:	WBGene00013727	Length:	385	Species:	Caenorhabditis elegans

Alignment Length:	396	Identity:	98/396 - (24%)
Similarity:	160/396 - (40%)	Gaps:	128/396 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 EYEVLEFLGRGTFGQV-------------VKCWKRG-----------TSEIVAIKILKNHPSYAR 231
            :.|.:..||.|.||.|             :|.:|.|           .|||:......:||:..:
Worm    49 DLENVSVLGEGVFGTVFEVADAEKKKKFALKLFKAGHTQFGCEDWVRESEIMKSVAAAHHPNLIK 113

  Fly   232 -----------QGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNK 285
                       :|.:.::||..|..::                     :|.:::....:.  .||
Worm   114 LVKSGKMASVPEGYLRIAILMELRGKS---------------------LFSVMDSTKSEV--PNK 155

  Fly   286 FSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIML----------------VDPVRQPYR 334
            ....|:..||.|..|:|:|:.||:::.::|.|||||||..                :.| .:...
Worm   156 EISFPIATIREIGAQILSAMKKLEKMEIVHLDLKPENICFTSTCTFTTEIRKDVCYISP-SEELN 219

  Fly   335 VKVIDFGSA--SHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGS 397
            |.:||||:|  |:......:..:|::.||||||.:||||....|:||.||:::||:.|..|:.|:
Worm   220 VCIIDFGNARKSNQEDLKSSEVVQTQNYRAPEIFMGLPFSTRSDVWSFGCILSELYTGELLFYGN 284

  Fly   398 SEFD--QIRY-ISQ--TQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKE 457
            .|.|  |::: :.|  .|..|:..|:..|::..|
Worm   285 DEHDTEQLQFELMQLILQQAPSYLMMRKAAENKK------------------------------- 318

  Fly   458 ARKYIFNCLDDIGQVNVPTDLEGG---QLLAEKTDRRE------FIDLLKRMLTIDQERRLTPAE 513
              |.|  |:|  |.|.:....:..   .|...|..||.      ..:||:|:|..|..||||.:|
Worm   319 --KMI--CID--GNVYMKKRAKSSFDPPLPLYKQRRRNDRAAIPLFELLERILIFDPTRRLTFSE 377

  Fly   514 ALNHSF 519
            ..:.:|
Worm   378 ISSETF 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	98/395 (25%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Y111B2A.1	NP_499631.2	PKc_like	56..>193	CDD:389743	36/159 (23%)
Y111B2A.1	NP_499631.2	PKc_like	<130..384	CDD:389743	82/315 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163635
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.830