Protein Alignment Hipk and mbk-1

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_510460.2
• Gene: mbk-1 / 181578
• WormBaseID: WBGene00003149
• Length: 882
• Species: Caenorhabditis elegans
• Alignment Length: 790
• Identity: 210/790 - (26%)
• Similarity: 307/790 - (38%)
• Gaps: 257/790 - (32%)

  Fly    44 QTVTATTDGTRHQEQQQQQLQQQQQQHILRQ--------------PATSASTSSVA--------- 85
            |.|.|.....:.::|:||.:|||..|..:.|              |.||..|:|.|
 Worm    54 QDVQADELQKQQKQQEQQHIQQQNAQRFIAQSRQPHSNILRFPQPPITSIKTNSHAFYPQQEVTQ 118

  Fly    86 --------------AAAT--------SKRKR-----QTD---CDCGCVDSYNSSHGPPVQ----- 115
                          ||.|        :.:||     .||   ...|.:.....|...|:|
 Worm   119 VRPKKHRVSMTNAEAALTPGMPPEKQAAKKRNIGQFSTDTVPAGIGMIGIPFESTSKPLQIQQFR 183

  Fly   116 --------------------------------QDSSAAAGAGS-VGSKAGSGPG-PDGIG----- 141
                                            :|...:..||. .|||.|||.. .|...
 Worm   184 NPQDAPVRKLTSDLIKTYKAINESFYLRKQVRRDRHKSQDAGKPKGSKDGSGASLTDTFSIHNAI 248

  Fly   142 PISSLKTAHTKVATSGGHANTQP-----------------------PSKRSSSGADG-------- 175
            ||:|....:.:.|    |.|..|                       ..:|..|...|
 Worm   249 PITSSDNHYQQDA----HQNAPPLLDTNAPPTSTMVVPMRTETDLQQQQRQKSSRGGPYNNGYDD 309

  Fly   176 ---DYQLVQHEVLYSLSAEYEVLEF--LGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQI 235
               ||.|...|:   ....|.:|..  :|:|:||||.|.:.....|.|||||:||..::..|.||
 Worm   310 QNYDYILKNGEI---FDKRYVILSDTPVGKGSFGQVTKAYDTLNKEEVAIKIIKNKKTFFDQAQI 371

  Fly   236 EVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILE 299
            |:.:|...:..:.| ::|.|.....|.|:.|.|||||:|..||||.||...|..:.|...|...:
 Worm   372 EIHLLELTNAHDKDNKYNIVTLKGHFVHRAHLCLVFELLSYNLYDLLKNTSFRGVSLNLARKFAQ 436

  Fly   300 QVLTALLKLK--QLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNT------YLQ 356
            |:...||.|.  :|.:||.||||||::||:..|.  :::||||||:       |.|      |:|
 Worm   437 QLGKTLLFLSSPELSIIHCDLKPENVLLVNAKRS--QIRVIDFGSS-------CQTGHRIYQYIQ 492

  Fly   357 SRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSA 421
            ||:||:||::||:.:...||||||||::.|:..|.||:.||||.||:..|.:..|:|.:.||:..
 Worm   493 SRFYRSPEVLLGIAYDTKIDMWSLGCILVEMHTGEPLFAGSSEVDQMMKIVEVLGMPPKEMLDIG 557

  Fly   422 SKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAE 486
            .||.|:|.:..|..|   ..|.|.:....| .|:..|||     |.:|  :.|.:...||:.|.|
 Worm   558 PKTHKYFDKTEDGIY---YCKKTRDGYRHT-YKAPGARK-----LHEI--LGVTSGGPGGRRLGE 611

  Fly   487 K----TDRREFIDLLKRMLTIDQERRLTPAEALNHSFTR-----------LTHLVDYVYCNNVKA 536
            .    .|..:|.||:||||..|.::|::|...:.|.|.:           ::|       :|::.
 Worm   612 PGHSVEDYSKFKDLIKRMLQFDPKQRISPYYVVRHPFLKQKEERVPSQPPVSH-------SNLQQ 669

  Fly   537 SVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQIY 601
            ..|:.          :|..|:.::..:.|.:....:..:|                   |:|:..
 Worm   670 QQQLY----------IQQPSSQMSQVMESPSVGSVYVEDN-------------------GMYRQA 705

  Fly   602 NGRSVARQYPQTRTDSFQ----------------HQLVSNILCPPSYQTMPSPTKHVVVGSATMQ 650
            .|.|.   .|.:.|.||.                ||...:   .|:||               ..
 Worm   706 PGSSA---NPISVTSSFDEGDAMEVDAGRRRFSAHQQNYH---NPNYQ---------------YS 749

  Fly   651 PPLQVPPQQY 660
            .|.|...|||
 Worm   750 QPQQQQQQQY 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	132/342 (39%)
		PHA03378	<1080..1327	CDD:223065
mbk-1	NP_510460.2	PKc_DYRK1	312..651	CDD:271128	137/361 (38%)