DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and hpk-1

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_741761.1	Gene:	hpk-1 / 180695	WormBaseID:	WBGene00001994	Length:	846	Species:	Caenorhabditis elegans

Alignment Length:	923	Identity:	371/923 - (40%)
Similarity:	463/923 - (50%)	Gaps:	227/923 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QQQHILRQPATSASTSSVAAAATSKRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAG-------A 124
            |.|..|..||...|...  |..||              |.|....|..:.|..|...       .
Worm    37 QSQLNLTAPANPFSIQK--APGTS--------------SDNEQRAPKRRADEEAVNAVPKNLLTT 85

  Fly   125 GSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYS-L 188
            .|..::|.....|       ::.:|:.|:|.....|..:..:.|.....:|:|||:::|||.| .
Worm    86 SSTFARAVIPAAP-------AISSANNKMAPQSVTATAKTTTNRGKVSGEGEYQLIKNEVLCSPY 143

  Fly   189 SAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADEFNF 253
            ..:||||||||:||||||||.||:||||||||||||.|||||||||||||||||||.||::||||
Worm   144 GNQYEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRLSNENSEEFNF 208

  Fly   254 VRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADL 318
            |||||||.||:||||||||||||||||||||||.||||..|||||.||||||||||.||||||||
Worm   209 VRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPLPLNAIRPILFQVLTALLKLKSLGLIHADL 273

  Fly   319 KPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCV 383
            ||||||||||.:|||||||||||||||.||.|.||||||||||||||||||||.|:|||||||||
Worm   274 KPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCV 338

  Fly   384 VAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYP--------FWR 440
            :|||||||||||||||:||||:|.||||||...||.||||..:|| ::|.|..|        ::|
Worm   339 IAELFLGWPLYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFF-KEVKSESPNHTNVGGSYYR 402

  Fly   441 LKTTEEHEAETNT-KSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTID 504
            |||.||:||.::| ||||.||||||.:|||.:|....:.:..:.|.::.||:||:|:||:||.::
Worm   403 LKTVEEYEASSSTAKSKETRKYIFNVIDDISRVCYGFESDPVEHLCDRIDRQEFVDVLKKMLVLN 467

  Fly   505 QERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTEN 569
            .:.|:||||.|...|..:||:..|.:.|.|..:.:.||:||:       |...:.|.
Worm   468 PDFRITPAEGLESKFVTMTHINGYNFANYVHEAHKRMEICRK-------PGPAMATP-------- 517

  Fly   570 MTFTINNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQT 634
                                           |...:||.  |.|..:.           ||:
Worm   518 -------------------------------YRAANVAT--PITPVEK-----------PPA--- 535

  Fly   635 MPSPTKHVVVGSATMQPPLQVPPQ----QYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTG 695
                       ....||.:.|.||    ...|:| ||    ||...   |||.:.........||
Worm   536 -----------PKLQQPMIAVLPQLNQIAATNIP-PV----PTQPD---LTNLMHHYSQMAAATG 581

  Fly   696 RQMALVPSWPQQAPAHSLIVDSTPLFNVEEIY------PKHHLNLPRNDLKKESPAHHIAKGNSY 754
            ........:.|..|       ..|||...:::      |.|.|:|       .:|:|
Worm   582 SAATAAQFFYQPLP-------PAPLFQYAQLHHPFAARPPHFLSL-------ATPSH-------- 624

  Fly   755 RVPRHEKKEHQQLSPVKKRVKESS-------PPHQQRYQRAAHVSPQYHAHHNCNYGNGS-GYSA 811
            .||        |..||.  :.:.|       |...|::...|:...:..|....|....| ..:.
Worm   625 MVP--------QFVPVP--IMDPSMLQGQWPPGAAQQFAVLANDIMRVPAPQGINQMFASTPQTF 679

  Fly   812 SAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPP 876
            |....::||..|::...||::.     ::|.    |..:||.        |.|.|.
Worm   680 SLPQFLSSSIPSATTAFNGNAP-----NIPF----PEENSSW--------ALGTAA--------- 718

  Fly   877 AHAHQQHGQQPHPQSSQHPQHVK------QPTITIHDTPSPTAVITISDSEDEGGEAGGAQVPVL 935
                ||..||.....|....:||      ||.   .::|:| :|||:|..||..|
Worm   719 ----QQQQQQAQRAQSMINGNVKVKPLAAQPK---KNSPAP-SVITLSSDEDSNG---------- 765

  Fly   936 KQRAHAQSQTSGS 948
                 |.|..|||
Worm   766 -----AGSSNSGS 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	247/336 (74%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
hpk-1	NP_741761.1	PKc_like	147..483	CDD:304357	247/336 (74%)
hpk-1	NP_741761.1	S_TKc	147..483	CDD:214567	247/336 (74%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	486	1.000	Domainoid score	I189
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	564	1.000	Inparanoid score	I588
Isobase	1	0.950	-	0	Normalized mean entropy	S2156
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002956
OrthoInspector	1	1.000	-	-		oto17675
orthoMCL	1	0.900	-	-		OOG6_103159
Panther	1	1.100	-	-	LDO	PTHR24058
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X805
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.910