Protein Alignment Hipk and hpk-1

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_741761.1
• Gene: hpk-1 / 180695
• WormBaseID: WBGene00001994
• Length: 846
• Species: Caenorhabditis elegans
• Alignment Length: 923
• Identity: 371/923 - (40%)
• Similarity: 463/923 - (50%)
• Gaps: 227/923 - (24%)

  Fly    67 QQQHILRQPATSASTSSVAAAATSKRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAG-------A 124
            |.|..|..||...|...  |..||              |.|....|..:.|..|...       .
 Worm    37 QSQLNLTAPANPFSIQK--APGTS--------------SDNEQRAPKRRADEEAVNAVPKNLLTT 85

  Fly   125 GSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYS-L 188
            .|..::|.....|       ::.:|:.|:|.....|..:..:.|.....:|:|||:::|||.| .
 Worm    86 SSTFARAVIPAAP-------AISSANNKMAPQSVTATAKTTTNRGKVSGEGEYQLIKNEVLCSPY 143

  Fly   189 SAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADEFNF 253
            ..:||||||||:||||||||.||:||||||||||||.|||||||||||||||||||.||::||||
 Worm   144 GNQYEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRLSNENSEEFNF 208

  Fly   254 VRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADL 318
            |||||||.||:||||||||||||||||||||||.||||..|||||.||||||||||.||||||||
 Worm   209 VRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPLPLNAIRPILFQVLTALLKLKSLGLIHADL 273

  Fly   319 KPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCV 383
            ||||||||||.:|||||||||||||||.||.|.||||||||||||||||||||.|:|||||||||
 Worm   274 KPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCV 338

  Fly   384 VAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYP--------FWR 440
            :|||||||||||||||:||||:|.||||||...||.||||..:|| ::|.|..|        ::|
 Worm   339 IAELFLGWPLYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFF-KEVKSESPNHTNVGGSYYR 402

  Fly   441 LKTTEEHEAETNT-KSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTID 504
            |||.||:||.::| ||||.||||||.:|||.:|....:.:..:.|.::.||:||:|:||:||.::
 Worm   403 LKTVEEYEASSSTAKSKETRKYIFNVIDDISRVCYGFESDPVEHLCDRIDRQEFVDVLKKMLVLN 467

  Fly   505 QERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTEN 569
            .:.|:||||.|...|..:||:..|.:.|.|..:.:.||:||:       |...:.|.
 Worm   468 PDFRITPAEGLESKFVTMTHINGYNFANYVHEAHKRMEICRK-------PGPAMATP-------- 517

  Fly   570 MTFTINNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQT 634
                                           |...:||.  |.|..:.           ||:
 Worm   518 -------------------------------YRAANVAT--PITPVEK-----------PPA--- 535

  Fly   635 MPSPTKHVVVGSATMQPPLQVPPQ----QYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTG 695
                       ....||.:.|.||    ...|:| ||    ||...   |||.:.........||
 Worm   536 -----------PKLQQPMIAVLPQLNQIAATNIP-PV----PTQPD---LTNLMHHYSQMAAATG 581

  Fly   696 RQMALVPSWPQQAPAHSLIVDSTPLFNVEEIY------PKHHLNLPRNDLKKESPAHHIAKGNSY 754
            ........:.|..|       ..|||...:::      |.|.|:|       .:|:|
 Worm   582 SAATAAQFFYQPLP-------PAPLFQYAQLHHPFAARPPHFLSL-------ATPSH-------- 624

  Fly   755 RVPRHEKKEHQQLSPVKKRVKESS-------PPHQQRYQRAAHVSPQYHAHHNCNYGNGS-GYSA 811
            .||        |..||.  :.:.|       |...|::...|:...:..|....|....| ..:.
 Worm   625 MVP--------QFVPVP--IMDPSMLQGQWPPGAAQQFAVLANDIMRVPAPQGINQMFASTPQTF 679

  Fly   812 SAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPP 876
            |....::||..|::...||::.     ::|.    |..:||.        |.|.|.
 Worm   680 SLPQFLSSSIPSATTAFNGNAP-----NIPF----PEENSSW--------ALGTAA--------- 718

  Fly   877 AHAHQQHGQQPHPQSSQHPQHVK------QPTITIHDTPSPTAVITISDSEDEGGEAGGAQVPVL 935
                ||..||.....|....:||      ||.   .::|:| :|||:|..||..|
 Worm   719 ----QQQQQQAQRAQSMINGNVKVKPLAAQPK---KNSPAP-SVITLSSDEDSNG---------- 765

  Fly   936 KQRAHAQSQTSGS 948
                 |.|..|||
 Worm   766 -----AGSSNSGS 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	247/336 (74%)
		PHA03378	<1080..1327	CDD:223065
hpk-1	NP_741761.1	Protein Kinases, catalytic domain	147..483	CDD:473864	247/336 (74%)
		Atrophin-1	<498..>758	CDD:460830	79/406 (19%)