Protein Alignment Hipk and mbk-2

DIOPT Version :9

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_001023207.1
• Gene: mbk-2 / 178250
• WormBaseID: WBGene00003150
• Length: 817
• Species: Caenorhabditis elegans
• Alignment Length: 650
• Identity: 182/650 - (28%)
• Similarity: 268/650 - (41%)
• Gaps: 169/650 - (26%)

  Fly     1 MKTSYPPKASDFVDYAVAGGGGSGFCSG-------LG------AGLSVRATSFYGDQTVTATTDG 52
            :.:|..|...::|..:....|...|.||       ||      |.|...|:|.|.:.
 Worm   166 INSSANPHLVNYVQTSSFDNGSYEFPSGQAQQQRRLGGSQQHLAPLQQTASSLYSNP-------- 222

  Fly    53 TRHQEQQQQQLQQQQ--------------QQHI-----------LRQPATSAS------------ 80
               |....|.|.|||              ||||           :|.|..|.:
 Worm   223 ---QSSSSQLLGQQQAVRPNYAYQQSLPRQQHINSHQTQAFFGTVRGPTNSTNIVTPLRASKTMI 284

  Fly    81 ------TSSVAAAATSKRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDG 139
                  ..:|||.||......|....|   |.|||.|       ..:.|:||:.:::..||....
 Worm   285 DVLAPVRDTVAAQATGLPNVGTSSSNG---SSNSSSG-------VGSGGSGSLMTQSIGGPNKHL 339

  Fly   140 IGPISSLKTA------HTKV--------------ATSGGHANTQPPSKRSSSG------------ 172
            ....|:|.||      |:|:              ::|||.......:..|:||
 Worm   340 SASHSTLNTASTHDMMHSKIPKSPSNESLSRSHTSSSGGSQGGHNSNSGSNSGFRPEDAVQTFGA 404

  Fly   173 ----------------------------------------ADGDYQLVQHEVLYSLSAEYEVLEF 197
                                                    .:|.||||.|:   .::..||||:.
 Worm   405 KLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHD---HIAYRYEVLKV 466

  Fly   198 LGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQ 261
            :|:|:||||:|.:.....:.||:|:::|...:.||...|:.||..|.::::| ..|.:...:.|.
 Worm   467 IGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFN 531

  Fly   262 HKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLV 326
            .:||.|:.||:|..|||:.:|:|||....|..:|.....:|..|..|::..|||.||||||::|.
 Worm   532 FRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLK 596

  Fly   327 DPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGW 391
            ...|.  .:|||||||:....:.: .||:|||:|||||:|||..:...||||||||::|||..|:
 Worm   597 QQGRS--GIKVIDFGSSCFDDQRI-YTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGY 658

  Fly   392 PLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSK 456
            ||.||..|.||:..|.:..|:|....|.:|.:...|.   ....||.:...|:....:.....::
 Worm   659 PLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFI---TSKGYPRYCTATSMPDGSVVLAGAR 720

  Fly   457 EARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTR 521
            ..|          |::..|..........:......|:|.|||.|..|.|.|:|||:||.|.:.|
 Worm   721 SKR----------GKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLR 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	119/328 (36%)
		PHA03378	<1080..1327	CDD:223065
mbk-2	NP_001023207.1	PKc_DYRK2_3	395..774	CDD:271126	125/397 (31%)
		S_TKc	461..774	CDD:214567	119/328 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940