DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk and prpf-4

DIOPT Version :9

Sequence 1:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001250391.1	Gene:	prpf-4 / 172443	WormBaseID:	WBGene00004186	Length:	775	Species:	Caenorhabditis elegans

Alignment Length:	532	Identity:	146/532 - (27%)
Similarity:	244/532 - (45%)	Gaps:	103/532 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GSGFCSGLGAGLSVRA-----TSFYG-----------------DQTVTATTDGTRHQEQQQQQLQ 64
            ||...||....:|:::     |.|:.                 |:.:....| ..::|....||:
Worm   307 GSEQGSGASTPVSIQSDNDTPTDFFSGLRDKMVHMKDADEHNVDEVLQRGKD-EEYREDWHTQLK 370

  Fly    65 QQQQQHILRQPATSASTSSVAAAATSKRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGS 129
            :|:::   .:........:.|||..:|:|:|.:.|.| .|.:..:...|  |||:
Worm   371 EQEKR---EEEEKKKKLEAEAAAEAAKKKKQEEDDTG-FDMFADNEELP--QDST---------- 419

  Fly   130 KAGSGPGPDGIGPISSLKTAHTKVATSGGHAN-TQPPSKRSSSGADGDYQLVQHEVLYSLSAEYE 193
                                     |..||:. .....|.:....:|.|::...|:   |...|.
Worm   420 -------------------------TIDGHSGAVHDTLKDNWDDVEGYYRVRIGEL---LDTRYR 456

  Fly   194 VLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQ-ENADEFNFVRAF 257
            |:.|.|.|.||.|.:|..:.....||:||::|:....:.|..|:.:|.:|:: :..|:::.:|.|
Worm   457 VVGFTGAGVFGNVCRCNDQTKGNTVAVKIIRNNEVMYKTGLRELEVLRKLNEADKEDKYHCLRLF 521

  Fly   258 ECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPE 321
            ..|:|.||.|||||.|..||.:.||: .:...|.||.:|...:|:|.||..||:|..:|||:||:
Worm   522 RTFKHHNHLCLVFENLSMNLRELLKKYGQKDGLHLKAVRSYAQQLLLALRLLKKLEFVHADIKPD 586

  Fly   322 NIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAE 386
            ||::.:   ....:|:.|||||..|::.....||.||:||||||:||:....|||:||:...:.|
Worm   587 NILVNE---SKLTLKLCDFGSAGRVNEQELAPYLVSRFYRAPEIMLGVRHDYAIDLWSVAVTLYE 648

  Fly   387 LFLGWPLYPGSSEFDQIRYISQTQG-LPTEHMLNSASKTSKF------FYRDVDSTYPFWRLKTT 444
            ::.|..::||.:....::..:..:| .|.:.:..|..|.:.|      .|::||        |.|
Worm   649 VYTGKIMFPGRTNNHMLKLFTDVKGKYPNKLVRKSQFKDTHFDVNCNLLYQEVD--------KVT 705

  Fly   445 EEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLA-EKTDR-REFIDLLKRMLTIDQER 507
            |.::.......|..|             ::.::|..||.|: ::.|: :.|..||..||.:|..:
Worm   706 ERNKITVLANLKPTR-------------DLESELIAGQRLSRDQMDQIQAFRTLLDGMLILDPSK 757

  Fly   508 RLTPAEALNHSF 519
            |.|..|||.|.|
Worm   758 RTTCNEALKHPF 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	112/339 (33%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
prpf-4	NP_001250391.1	STKc_PRP4	454..770	CDD:271037	112/340 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910